Results 31 to 40 of about 112,735 (309)

Metformin and high-sensitivity cardiac troponin I and T trajectories in type 2 diabetes patients: a post-hoc analysis of a randomized controlled trial

Cardiovascular Diabetology, 2022
Background Metformin has favorable effects on cardiovascular outcomes in both newly onset and advanced type 2 diabetes, as previously reported findings from the UK Prospective Diabetes Study and the HOME trial have demonstrated.
Johanna M. G. Stultiens, Wiebe M. C. Top, Dorien M. Kimenai, Philippe Lehert, Otto Bekers, Coen D. A. Stehouwer, Adriaan Kooy, Steven J. R. Meex   +7 more
doaj   +1 more source

The prognostic value of postoperative cardiac troponin I and T for major adverse cardiac events after coronary artery bypass grafting: a systematic review

BJA Open
Background: This systematic review describes the prognostic value of postoperative cardiac high-sensitive troponin I and T as risk markers for major adverse cardiac events (MACE) after coronary artery bypass graft (CABG) surgery and their predictive ...
Maaike S.Y. Thio, Peter G. Noordzij, Janice H. Klingenberg, Frieda Renkens, Lisette M. Vernooij, Olaf L. Cremer, Linda M. Posthuma, Thijs C.D. Rettig   +7 more
doaj   +1 more source

Cardiac troponin T: A sensitive and specific indicator of myocardial injury in patients with cerebrovascular stroke

The Egyptian Heart Journal, 2012
Background: Unsuspected morbidity and mortality in cerebrovascular stroke (CVS) patients remain a serious issue in critical medicine field. Patients with CVS are at increased risk of developing cardiac complications which explains the high morbidity and ...
Mohammed Amin, Adel Gamal, Mohammed Ali, Omar Awad   +3 more
doaj   +1 more source

ASK1 Associates with Troponin T and Induces Troponin T Phosphorylation and Contractile Dysfunction in Cardiomyocytes [PDF]

The American Journal of Pathology, 2003
There is increasing support for the idea that excessive production of proinflammatory mediators such as tumor necrosis factor (TNF) and reactive oxygen species (ROS) contribute to the pathogenesis of cardiac dysfunction. However, the mechanisms by which cytokine/ROS production mediates cardiac dysfunction have not been established. Given that apoptosis
Xiangrong, He, Yingmei, Liu, Virendra, Sharma, Robert T, Dirksen, Richard, Waugh, Shey-Shing, Sheu, Wang, Min   +6 more
openaire   +2 more sources

Assessment of cardiac troponins status in patients on regular hemodialysis

Advanced Medical Journal
Background and objectives: heart disease is a significant contributor to both fatalities and health issues among patients undergoing regular hemodialysis.
Raman Ameer Muhammed, Hussein Yousif Sinjari   +1 more
doaj   +1 more source

Troponin and anti-troponin autoantibody levels in patients with ventricular noncompaction. [PDF]

PLoS ONE, 2013
Ventricular hypertrabeculation/noncompaction is a morphologic and functional anomaly of myocardium characterized by prominent trabeculae accompanied by deep recessus.
Hatice Betül Erer, Tolga Sinan Güvenç, Ahu Sarbay Kemik, Hale Yaka Yılmaz, Şeref Kul, Servet Altay, Nurten Sayar, Yüksel Kaya, Mehmet Eren   +8 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Development of a sensitive immunosensor for the detection of cardiac Troponin T in cardiovascular disease [PDF]

, 2014
Cardiovascular disease (CVD) is currently globally the biggest cause of mortality, with rising figures, especially now in the developing world. Early and accurate diagnosis of CVD, (especially acute myocardial infarction (AMI) is important in being able ...
Pawula, Maria
core  

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Coaxially Electrospun Myocardial dECM‐ Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility

Advanced Healthcare Materials, EarlyView.
Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse, Mahtab Khodadadi, Kiran M. Ali, Suh Hee Cook, Bryson T. Proctor, Tanya Upadhyay, Daxian Zha, Fatema Tuj Jahura, Marziyeh Boosaliki, Jessica M. Gluck   +9 more
wiley   +1 more source