Results 31 to 40 of about 471,725 (296)

Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review. [PDF]

open access: yes, 2011
BACKGROUND: Interactions between spirometry and patient-reported outcomes in COPD are not well understood. This systematic review and study-level analysis investigated the relationship between changes in FEV1 and changes in health status with ...
Bourbeau, J   +5 more
core   +2 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle   +5 more
wiley   +1 more source

Early Vancomycin Concentrations and the Applications of a Pharmacokinetic Extrapolation Method to Recognize Sub-Therapeutic Outcomes

open access: yesPharmacy, 2016
Vancomycin trough concentrations should be measured within 30 min of the next dose, but studies have shown that troughs are often measured too early, producing erroneous results that could lead to dosing errors.
Oscar Santalo   +3 more
doaj   +1 more source

Hubble Advanced Camera for Surveys Observations of the z=6.42 Quasar SDSS 1148+5251: A Leak in the Gunn-Peterson Trough

open access: yes, 2004
The Hubble Advanced Camera for Surveys has been used to obtain a narrow-band image of the weak emission peak seen at lambda=7205 A in the Gunn-Peterson Ly beta absorption trough of the highest redshift quasar, SDSS J1148+5251.
Becker, Robert H.   +3 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Performance Simulation of Solar Trough Concentrators: Optical and Thermal Comparisons

open access: yesEnergies, 2023
The solar trough concentrator is used to increase the solar radiation intensity on absorbers for water heating, desalination, or power generation purposes. In this study, optical performances of four solar trough concentrators, viz.
Fei Cao   +4 more
doaj   +1 more source

Lunar radiator shade [PDF]

open access: yes, 1992
An apparatus for rejecting waste heat from a system located on or near the lunar equator is presented. The system utilizes a reflective catenary shaped trough deployed about a vertical radiator to shade the radiator from heat emitted by the hot lunar ...
Ewert, Michael K.
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Objective Identification of Trough Lines Using Gridded Wind Field Data

open access: yesAtmosphere, 2017
An objective method was developed to analyze longwave and shortwave trough lines in wind field data using different methods, given that these trough lines were researched in different ways.
Yan Huang, Qian Li, Yin Fan, Xi Dai
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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