Results 101 to 110 of about 11,892 (197)

Oral JAK Inhibitors as a Promising Therapeutic Strategy for Refractory Rosacea: A Systematic Review and Meta‐Analysis

Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
ABSTRACT Background Rosacea is a chronic inflammatory dermatosis. While standard therapies exist, managing refractory subtypes remains a therapeutic challenge. Oral Janus kinase (JAK) inhibitors have emerged as potential alternatives, but systematic evidence is lacking. Aims To evaluate the efficacy and safety of oral JAK inhibitors for rosacea through
Yu Peng, Mingzi Sun, Jiayu Chen, Xubo Huang, Fengchuan Zhang   +4 more
wiley   +1 more source

Impact of cold air exposure on respiratory physiology during light‐to‐moderate physical activity in healthy adults

Physiological Reports, Volume 14, Issue 5, March 2026.
Abstract Working in cold environments presents unique physiological challenges, and this study sought to investigate the specific impacts of cold air exposure on ventilation during light‐to‐moderate physical activity simulating occupational work demands.
Christopher L. Chapman, Adam W. Potter, Erica A. Schafer, Karl E. Friedl, J. Luke Pryor, David P. Looney   +5 more
wiley   +1 more source

Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

eLife
Multiple gut antimicrobial mechanisms are coordinated in space and time to efficiently fight foodborne pathogens. In Drosophila melanogaster, production of reactive oxygen species (ROS) and antimicrobial peptides (AMPs) together with intestinal cell ...
Fatima Tleiss, Martina Montanari, Romane Milleville, Olivier Pierre, Julien Royet, Dani Osman, Armel Gallet, C Leopold Kurz   +7 more
doaj   +1 more source

STIMATE‐Mustn1 Fusion Protein Prevents Ca2+ Overload in Cells That Present Increased SOCE

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
STIMATE‐mustn1 fused protein expression downregulates Thr‐evoked Ca2+ entry in neonatal platelets. Meanwhile, maternal platelets express the canonical STIMATE, which promotes the Thr‐dependent Ca2+ entry. Impaired Ca2+ entry in neonatal platelets may contribute to the alteration in platelet aggregation found in these subjects. ER, endoplasmic reticulum.
Alejandro Berna‐Erro, Pedro J. Camello, María P. Granados, Elena Delgado, Esperanza Fernández, Raúl Teruel‐Montoya, Francisca Ferrer‐Marín, Juan A. Rosado, Pedro C. Redondo   +8 more
wiley   +1 more source

Dual role of transient receptor potential ankyrin 1 in respiratory and gastrointestinal physiology: From molecular mechanisms to therapeutic targets

Frontiers in Physiology
The transient receptor potential ankyrin 1 (TRPA1) channel plays a pivotal role in the respiratory and gastrointestinal tracts. Within the respiratory system, TRPA1 exhibits diverse distribution patterns across key cell types, including epithelial cells,
Kavya Reddy Tekulapally, Ji Yeon Lee, Dong Seop Kim, Md. Mahbubur Rahman, Chul-Kyu Park, Yong Ho Kim   +5 more
doaj   +1 more source

TRPA1 in Inflammation

, 2016
Tulehdus on elimistön suojamekanismi ulkoisia taudinaiheuttajia vastaan. Sen tarkoituksena on poistaa uhkaava tekijä sekä palauttaa kohde-elimen ja elimistön tasapaino. Tulehdusreaktion oireita ovat punoitus, kuumotus, turvotus ja kipu. Immuunijärjestelmä pyrkii kohdentamaan tulehdusreaktion oikeisiin kohteisiin sopivissa mittasuhteissa, mutta ...
openaire   +2 more sources

TRPA1 Gene [PDF]

, 2020
openaire   +1 more source

Ultrasonic repression of TRPA1-dependent astrocyte reactivity confers neuroprotection in models of Lewy body dementia. [PDF]

Transl Neurodegener
Kim JH, Lee K, Koo M, Kim D, Hong JK, Choi JY, Ko HS, Shin JH, Park JM, Park J, Lee Y.   +10 more
europepmc   +1 more source

TRPA1 promotes overactive bladder progression by activating the NLRP3 inflammasome and driving pyroptosis. [PDF]

Cell Death Dis
Rao Y, Wang Y, Gao J, Guan X, Lv S, Gu J, Wang K.   +6 more
europepmc   +1 more source

Bioelectronic synthesis of hydrogen sulfide enables spatiotemporal regulation of protein modification and cellular redox. [PDF]

Sci Adv
Lim L, Lee C, Lee J, Lee M, Kim Y, Lee TK, Lee G, Kim J, Oh SY, Kim J, Park J.   +10 more
europepmc   +1 more source