Results 171 to 180 of about 13,150 (209)

TRPA1 modulators in preclinical development

Expert Opinion on Therapeutic Patents, 2009
Transient receptor potential ankyrin 1 (TRPA1) has been revealed as a pivotal molecular entity in sensory biology, especially as a sensor of chemical irritants present in foods, atmospheric pollutants and neurotoxic compounds. In addition, this channel appears responsible for detecting physical signals such as noxious cold and mechanical forces.There ...
Viana, Félix, Ferrer-Montiel, Antonio
openaire   +3 more sources

TRPA1-Kationenkanäle

2019
Der „Transient Receptor Potential Ankyrin 1“ (TRPA1) Kanal zeichnet sich als Mitglied der TRP-Familie durch eine größere Zahl an sog. „Ankyrin-Repeats“ im Aminoterminus aus. Ansonsten besitzt er wie alle anderen TRP-Kanäle intrazelluläre Termini und sechs Transmembrandomänen mit einem Poren-bildenden Bereich zwischen der Domäne fünf und sechs.
openaire   +1 more source

Orientation of the tryptophanyl side chain in [(d)TrpA1] and [TrpA1]insulin

Journal of Protein Chemistry, 1983
Insulin analogues withl- andd-tryptophan instead of glycine in A1 permit an estimate of the proximity relationship between the indole residue of tryptophan and B19-tyrosine by evaluation of singlet-singlet resonance energy transfer. A significantly higher transfer efficiency is observed with [(d)TrpA1]insulin than with the [TrpA1]analogue. On the basis
Peter W. Schiller, Rolf Geiger
openaire   +1 more source

TRPA1

2006
Sven-Eric Jordt, Marilia Guimaraes
openaire   +2 more sources

TRPA1-mediated nociception

Neuroscience, 2008
L, Fischer, C H, Tambeli, C A, Parada
openaire   +2 more sources

A TRPA1 Inhibitor Suppresses Neurogenic Inflammation and Airway Contraction for Asthma Treatment

Journal of Experimental Medicine, 2021
Justin Elstrott, Vishal A Verma, Brian S Safina   +2 more
exaly  

Structural Insights Into Electrophile Irritant Sensing by the Human TRPA1 Channel

Neuron, 2020
Zi-Long Wang, Mario J Borgnia, Seok-Yong Lee   +2 more
exaly  

A Non-Covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel

Neuron, 2021
Brian S Safina, Huifen Chen, Jianyong Wang   +2 more
exaly  

Cancer Cells Co-Opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

Cancer Cell, 2018
Yasuo Mori, Daniel G. Stover, Gordon B. Mills   +2 more
exaly  

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain

Cell, 2019
John V Lin King, Katalin F Medzihradszky, Glenn F King   +2 more
exaly