Results 191 to 200 of about 14,118 (233)
Sleep drive, not total sleep amount, increases seizure risk. [PDF]
Nat CommunCuddapah VA +12 more
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Machine learning-based characterization of a PANoptosis-associated model for enhancing prognosis and immunotherapy response in lung adenocarcinoma patients. [PDF]
Discov OncolFu Z, Zeng J, Xiong X, Zhong W.
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2014
The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation channel permeable to Ca(2+), Na(+), and K(+). TRPA1 is a promiscuous chemical nocisensor that is also involved in noxious cold and mechanical sensation. It is present in a subpopulation of Aδ- and C-fiber nociceptive sensory neurons as well as in other sensory ...
Peter M, Zygmunt, Edward D, Högestätt
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The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation channel permeable to Ca(2+), Na(+), and K(+). TRPA1 is a promiscuous chemical nocisensor that is also involved in noxious cold and mechanical sensation. It is present in a subpopulation of Aδ- and C-fiber nociceptive sensory neurons as well as in other sensory ...
Peter M, Zygmunt, Edward D, Högestätt
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2007
The TRPA1 protein has up to 18 N-terminal and presumed cytoplasmic ankyrin repeats followed by the six membrane spanning and single pore-loop domains characteristic of all TRPs. In mice, TRPA1 is almost exclusively expressed in nociceptive neurons of peripheral ganglia and in all the mechanosensory epithelia of inner ear.
J, García-Añoveros, K, Nagata
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The TRPA1 protein has up to 18 N-terminal and presumed cytoplasmic ankyrin repeats followed by the six membrane spanning and single pore-loop domains characteristic of all TRPs. In mice, TRPA1 is almost exclusively expressed in nociceptive neurons of peripheral ganglia and in all the mechanosensory epithelia of inner ear.
J, García-Añoveros, K, Nagata
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Pulmonary Pharmacology & Therapeutics, 2011
In the early 1990's ion channels of the Transient Receptor Potential (TRP) class were implicated in the afferent sensory loop of the cough reflex and in the heightened cough sensitivity seen in disease. Agonists of the TRPV1 capsaicin receptor such as vanilloids and protons were demonstrated to be amongst the most potent chemical stimuli which cause ...
Megan S, Grace, Maria G, Belvisi
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In the early 1990's ion channels of the Transient Receptor Potential (TRP) class were implicated in the afferent sensory loop of the cough reflex and in the heightened cough sensitivity seen in disease. Agonists of the TRPV1 capsaicin receptor such as vanilloids and protons were demonstrated to be amongst the most potent chemical stimuli which cause ...
Megan S, Grace, Maria G, Belvisi
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2007
Genetic and molecular searches in animals identify two families of ion channels used by specialized mechanosensory cells. These are the degenerin/epithelial Na+ channels (Deg/ENaCs) and transient receptor potential (TRP) channels. Some of these channels open in response to mechanical forces and/or mediate cellular responses to mechanical stimulation ...
Andrew J, Castiglioni +1 more
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Genetic and molecular searches in animals identify two families of ion channels used by specialized mechanosensory cells. These are the degenerin/epithelial Na+ channels (Deg/ENaCs) and transient receptor potential (TRP) channels. Some of these channels open in response to mechanical forces and/or mediate cellular responses to mechanical stimulation ...
Andrew J, Castiglioni +1 more
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TRPA1 gene variants hurting our feelings
Pflügers Archiv - European Journal of Physiology, 2020TRPA1 is a Ca2+-permeable, non-selective cation channel that is activated by thermal and mechanical stimuli, an amazing variety of potentially noxious chemicals, and by endogenous molecules that signal tissue injury. The expression of this channel in nociceptive neurons and epithelial cells puts it at the first line of defense and makes it a key ...
Robbe Naert +3 more
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2019
Der „Transient Receptor Potential Ankyrin 1“ (TRPA1) Kanal zeichnet sich als Mitglied der TRP-Familie durch eine größere Zahl an sog. „Ankyrin-Repeats“ im Aminoterminus aus. Ansonsten besitzt er wie alle anderen TRP-Kanäle intrazelluläre Termini und sechs Transmembrandomänen mit einem Poren-bildenden Bereich zwischen der Domäne fünf und sechs.
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Der „Transient Receptor Potential Ankyrin 1“ (TRPA1) Kanal zeichnet sich als Mitglied der TRP-Familie durch eine größere Zahl an sog. „Ankyrin-Repeats“ im Aminoterminus aus. Ansonsten besitzt er wie alle anderen TRP-Kanäle intrazelluläre Termini und sechs Transmembrandomänen mit einem Poren-bildenden Bereich zwischen der Domäne fünf und sechs.
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Intracellular zinc irritates TRPA1
Nature Chemical Biology, 2009Exposure to zinc can cause pain and inflammation and can be harmful to human health. New evidence suggests that activation of the irritant receptor, TRPA1, which is expressed on pain-sensing neurons, may be responsible for some of these symptoms of zinc toxicity.
Banke, Tue G, Wickenden, Alan D
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