Results 81 to 90 of about 11,892 (197)
Journal of Inflammation, 2018 Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger.
Songjiang Yin +7 more
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Renal Disease Burden in Prurigo Nodularis: A Systematic Review and Meta‐Analysis
International Journal of Dermatology, EarlyView.
Natalia Chalupczak +3 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
TRPA1: irritant detector of the airways
The Journal of Physiology, 2008 The respiratory tract is innervated by primary afferent sensory neurons that respond to mechanical and chemical stimuli (Taylor-Clark & Undem, 2006). The majority of these neurons are unmyelinated C-fibres that respond to noxious chemicals, such as reactive oxygen species (ROS), the main irritants of tear gas, air pollution and burning vegetation ...
K A, Gerhold, D M, Bautista
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The Excelsatoxin A‐Receptor TMEM233 Modulates Nav1.8
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.TMEM233 is a largely uncharacterized transmembrane protein that enables the sensitivity of Nav1.8 to Excelasatoxin A, a naturally occurring peptide that can significantly reduce the fast inactivation of this ion channel (left) expressed in sensory neurons or different cell lines. Moreover, its presence enhances the use dependent block of Nav1.8 induced
George Oprita +13 more
wiley +1 more source
Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium
Advanced Science, Volume 13, Issue 14, 9 March 2026.This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du +5 more
wiley +1 more source
Journal of Inflammation ResearchKaifang Yao,1,* Zhihan Chen,1,* Yanwei Li,1 Baomin Dou,1 Zhifang Xu,1– 3 Yajing Ma,1 Simin Du,1 Jiangshan Wang,1 Jiangjiang Fu,1 Qi Liu,1 Zezhi Fan,1 Yangyang Liu,1– 3 Xiaowei Lin,1– 3 Yuan Xu,1– 3 Yuxin Fang,1– 3 Shenjun Wang,1– 3 Yi Guo1,3,4 ...
Yao K +16 more
doaj
Warmth suppresses and desensitizes damage-sensing ion channel TRPA1
Molecular Pain, 2012 Background Acute or chronic tissue damage induces an inflammatory response accompanied by pain and alterations in local tissue temperature. Recent studies revealed that the transient receptor potential A1 (TRPA1) channel is activated by a wide variety of
Wang Sen +3 more
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Food Frontiers, Volume 7, Issue 2, March 2026.This study proposes the upcycling of oriental melon (Cucumis melo var. makuwa) stems, typically discarded as agricultural waste, into a bioactive extract with functional potential. CMSE ameliorates high‐fat‐diet‐induced obesity and fatty liver, contributing to the restoration of metabolic health by enhancing the expression of thermogenesis‐related ...
Myeong‐Jin Kim +10 more
wiley +1 more source
Roles of TRPA1 in Painful Dysesthesia
YAKUGAKU ZASSHI, 2020 Dysesthesia is an unpleasant abnormal sensation, often accompanied by pain, paresthesia (abnormal sensation), and numbness (decrease or loss of sensation). Dysesthesia has been associated with various conditions, although its underlying mechanisms are largely unknown.
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