Results 81 to 90 of about 14,118 (233)

TRPM8 Regulates Mitochondrial Ca2+‐Dynamics, Temperature and Endoplasmic Reticulum‐Mitochondrial Contact Points in T Cell

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT TRPM8 is a cold temperature‐sensitive and non‐selective Ca2+‐channel. Previously we have observed that TRPM8 is endogenously expressed and affects T cell activation process. Now, we report that TRPM8 regulates functions of mitochondria and ER, two important sub‐cellular compartments.
Tusar Kanta Acharya, Shamit Kumar, Tejas Pravin Rokade, Parnasree Mahapatra, Young Tae Chang, Chandan Goswami   +5 more
wiley   +1 more source

TRPA1: irritant detector of the airways

The Journal of Physiology, 2008
The respiratory tract is innervated by primary afferent sensory neurons that respond to mechanical and chemical stimuli (Taylor-Clark & Undem, 2006). The majority of these neurons are unmyelinated C-fibres that respond to noxious chemicals, such as reactive oxygen species (ROS), the main irritants of tear gas, air pollution and burning vegetation ...
K A, Gerhold, D M, Bautista
openaire   +3 more sources

Camphor Attenuates Hyperalgesia in Neuropathic Pain Models in Mice

Journal of Pain Research, 2023
Ziyuan Li,1,* Yu Gan,1,* Ting Kang,1,* Yi Zhao,1 Tianguang Huang,2 Yuhao Chen,3 Jin Liu,1 Bowen Ke1 1Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of ...
Li Z, Gan Y, Kang T, Zhao Y, Huang T, Chen Y, Liu J, Ke B   +7 more
doaj  

Warmth suppresses and desensitizes damage-sensing ion channel TRPA1

Molecular Pain, 2012
Background Acute or chronic tissue damage induces an inflammatory response accompanied by pain and alterations in local tissue temperature. Recent studies revealed that the transient receptor potential A1 (TRPA1) channel is activated by a wide variety of
Wang Sen, Lee Jongseok, Ro Jin Y, Chung Man-Kyo   +3 more
doaj   +1 more source

TRPA1 Ion Channel Mediates the Analgesic Effects of Acupuncture at the ST36 Acupoint in Mice Suffering from Arthritis

Journal of Inflammation Research
Kaifang Yao,1,* Zhihan Chen,1,* Yanwei Li,1 Baomin Dou,1 Zhifang Xu,1– 3 Yajing Ma,1 Simin Du,1 Jiangshan Wang,1 Jiangjiang Fu,1 Qi Liu,1 Zezhi Fan,1 Yangyang Liu,1– 3 Xiaowei Lin,1– 3 Yuan Xu,1– 3 Yuxin Fang,1– 3 Shenjun Wang,1– 3 Yi Guo1,3,4 ...
Yao K, Chen Z, Li Y, Dou B, Xu Z, Ma Y, Du S, Wang J, Fu J, Liu Q, Fan Z, Liu Y, Lin X, Xu Y, Fang Y, Wang S, Guo Y   +16 more
doaj  

Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

Journal of Inflammation, 2018
Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger.
Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang, Jun Mao   +7 more
doaj   +1 more source

O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses [PDF]

, 2020
Makoto Uchiyama, Akito Nakao, Yuki Kurita, Isato Fukushi, Kotaro Takeda, Tomohiro Numata, Ha Nam Tran, Seishiro Sawamura, Maximilian C. C. J. C. Ebert, Tatsuki Kurokawa, Reiko Sakaguchi, Alexander J. Stokes, Nobuaki Takahashi, Yasumasa Okada, Yasuo Mori   +14 more
openalex   +1 more source

Roux-en-Y gastric bypass enhances insulin secretion in type 2 diabetes via FXR-mediated TRPA1 expression

Molecular Metabolism, 2019
Objective: Roux-en-Y gastric bypass surgery (RYGB) improves the first phase of glucose-stimulated insulin secretion (GSIS) in patients with type 2 diabetes. How it does so remains unclear.
Xiangchen Kong, Yifan Tu, Bingfeng Li, Longmei Zhang, Linxian Feng, Lixiang Wang, Lin Zhang, Huarong Zhou, Xianxin Hua, Xiaosong Ma   +9 more
doaj   +1 more source

Roles of TRPA1 in Painful Dysesthesia

YAKUGAKU ZASSHI, 2020
Dysesthesia is an unpleasant abnormal sensation, often accompanied by pain, paresthesia (abnormal sensation), and numbness (decrease or loss of sensation). Dysesthesia has been associated with various conditions, although its underlying mechanisms are largely unknown.
openaire   +3 more sources

TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis

Frontiers in Pharmacology, 2019
Modulation of nociception and inflammation by sulfide in rheumatoid arthritis and activation of transient receptor potential ankyrin 1 (TRPA1) ion channels by sulfide compounds are well documented.
István Z. Bátai, Cecília Pápainé Sár, Ádám Horváth, Éva Borbély, Kata Bölcskei, Ágnes Kemény, Ágnes Kemény, Zoltán Sándor, Balázs Nemes, Zsuzsanna Helyes, Anikó Perkecz, Attila Mócsai, Attila Mócsai, Gábor Pozsgai, Erika Pintér   +14 more
doaj   +1 more source