Results 181 to 190 of about 4,899 (211)
PIP2 regulation of TRPC5 channel activation and desensitization [PDF]
Journal of Biological Chemistry, 2021 Transient receptor potential canonical type 5 (TRPC5) channels are expressed in the brain and kidney, and have been identified as promising therapeutic targets whose selective inhibition can protect against diseases driven by a leaky kidney filter. They are activated by elevated levels of extracellular Ca2+or application of lanthanide ions but also by ...
Diomedes Logothetis +2 more
exaly +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
TRPC5 channel modulates endothelial cells senescence
European Journal of Pharmacology, 2017As a Ca2+-permeable cationic channel, canonical transient receptor potential 5 channel (TRPC5) has been known to be involved in various functions of cells. Although TRPC5 is abundantly expressed in vascular endothelium, it remains unknown whether TRPC5 plays a role in regulating endothelial senescence.
Cui Yang
exaly +3 more sources
Neurochemistry International, 2023
Mechanical allodynia is a serious complication of painful diabetic neuropathy (PDN) with limited treatment options. The transient receptor potential canonical 5 (TRPC5) channel is a promising target in pain; however, its role in painful diabetic neuropathy has not yet been elucidated. In this study, we have investigated the role of TRPC5 channels using
Pratik Adhya +2 more
openaire +2 more sources
Mechanical allodynia is a serious complication of painful diabetic neuropathy (PDN) with limited treatment options. The transient receptor potential canonical 5 (TRPC5) channel is a promising target in pain; however, its role in painful diabetic neuropathy has not yet been elucidated. In this study, we have investigated the role of TRPC5 channels using
Pratik Adhya +2 more
openaire +2 more sources
Inhibition of TRPC5 Channels by Intracellular ATP
Molecular Pharmacology, 2008TRPC5 channels are Ca(2+)-permeable nonselective cation channels activated by G-protein-coupled receptors, although the mechanisms responsible for channel activation and regulation are poorly understood. Carbachol-activated TRPC5 currents were recorded by the whole-cell patch clamp technique from human embryonic kidney 293 cells transiently transfected
Michael, Dattilo +2 more
openaire +2 more sources
Calpains Cleave and Activate TRPC5
Science Signaling, 2012Cleavage and activation of the cation channel TRPC5 by calpains may contribute to growth cone collapse.
openaire +1 more source
Extracellular disulfide bridges stabilize TRPC5 dimerization, trafficking, and activity
Pflügers Archiv - European Journal of Physiology, 2014Crucial cysteine residues can be involved in the modulation of protein activity via the modification of thiol (-SH) groups. Among these reactions, disulfide bonds (S-S) play a key role in the folding, stability, and activity of membrane proteins.
Chansik, Hong +6 more
openaire +2 more sources
Bipolar phospholipid sensing by TRPC5 calcium channel
Biochemical Society Transactions, 2007TRPC5 [TRP (transient receptor potential) canonical (or classical) 5] is a widely expressed mammalian homologue of Drosophila TRP, forming a calcium- and sodium-permeable channel in the plasma membrane either as a homomultimer or heteromultimer with other proteins (e.g. TRPC1).
openaire +2 more sources
2014
Human canonical transient receptor potential channel 5 (TRPC5) has been cloned from the Xq23 region on chromosome X as a suspect in nonsyndromic mental retardation. TRPC5 is a Ca(2+)-permeable cation channel predominantly expressed in the CNS, including the hippocampus, cerebellum, amygdala, sensory neurons, and retina.
openaire +2 more sources
Human canonical transient receptor potential channel 5 (TRPC5) has been cloned from the Xq23 region on chromosome X as a suspect in nonsyndromic mental retardation. TRPC5 is a Ca(2+)-permeable cation channel predominantly expressed in the CNS, including the hippocampus, cerebellum, amygdala, sensory neurons, and retina.
openaire +2 more sources
Role of Odontoblast TRPC5 in Dentin Hypersensitivity
2021Dentin hypersensitivity (DH) is a relatively common painful condition among dental problems for which several treatment options have been tested. Although many studies have been performed regarding the diagnosis and treatment of DH, dental professionals are still confused about the definite diagnosis and treatment.
Tushar Bhople, Priyanka Zille Bhople
openaire +1 more source