Results 201 to 210 of about 4,899 (211)

Inhibition of the TRPC5 ion channel protects the kidney filter

Journal of Clinical Investigation, 2013
Sookyung Kim, Samy Hakroush, Johannes Elvin   +2 more
exaly  

Charakterisierung des Trpc5-Kanals im Epithel der Trachea

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openaire   +1 more source

A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels

Cell Calcium, 2017
Holger Beckmann, Kerstin Hill, Nicole Urban   +2 more
exaly  

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

Science Advances, 2019
Jingjing Duan, Jian Li, Gui-Lan Chen
exaly  

TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain

Neuron, 2001
David E Clapham
exaly  

Trpc5 deficiency causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus

Proceedings of the National Academy of Sciences of the United States of America, 2019
Martina Pyrski, Bernd Bufe, Petra Weißgerber   +2 more
exaly  

Selective Gαi Subunits as Novel Direct Activators of Transient Receptor Potential Canonical (TRPC)4 and TRPC5 Channels

Journal of Biological Chemistry, 2012
Chansik Hong, Ju-Hong Jeon, Nam-Hyuk Cho
exaly  

Funkční interakce iontových kanálů TRPA1 a TRPC5

A subset of transient receptor potential channels (TRP) is expressed on the peripheral endings of sensory neurons and is involved in pain, thus representing an attractive target for its treatment. TRP channels function as tetramers. They are mostly composed of 4 identical subunits and form homomeric channels.
openaire   +1 more source

Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model

ACS Medicinal Chemistry Letters, 2019
Maolin Yu, Matthew Daniels, Goran Malojcic   +2 more
exaly  

Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903

Bioorganic and Medicinal Chemistry Letters, 2019
Anna Greka, Corey R Hopkins
exaly