Results 151 to 160 of about 1,209,942 (198)

Inhibition of TRPC6 channel suppresses bladder cancer proliferation by disrupting store-operated calcium entry. [PDF]

Sci Rep
Zha J, Guo X, Liao W, Wu P, Wu Y, Guo Y, Yang W, Gao L.   +7 more
europepmc   +1 more source

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TRPC Channel Structure and Properties

Advances in Experimental Medicine and Biology, 2017
TRPC channels are the first identified members in the TRP family. They function as either homo- or heterotetramers regulating intracellular Ca2+ concentration in response to numerous physiological or pathological stimuli. TRPC channels are nonselective cation channels permeable to Ca2+.
Shengjie Feng
exaly   +3 more sources

TRPC Channels in Health and Disease

, 2017
This chapter offers a brief introduction of the functions of TRPC channels in non-neuronal systems. We focus on three major organs of which the research on TRPC channels have been most focused on: kidney, heart, and lung. The chapter highlights on cellular functions and signaling pathways mediated by TRPC channels.
Yilin, Tai, Shenglian, Yang, Yong, Liu, Wei, Shao   +3 more
openaire   +3 more sources

TRPC Channel Downstream Signaling Cascades

Advances in Experimental Medicine and Biology, 2017
The family of TRP channel is comprised of a large group of cation-permeable channels, displaying as signaling integrators for sensing extracellular stimulus and initiating intracellular signaling cascades. This chapter offers a brief review of the signaling molecules related to TRPC channels, the first identified mammalian TRP family.
Zhuohao He
exaly   +3 more sources

Trafficking mechanisms and regulation of TRPC channels

Cell Calcium, 2014
TRPC channels are Ca(2+)-permeable cation channels which are regulated downstream from receptor-coupled PIP2 hydrolysis. These channels contribute to a wide variety of cellular functions. Loss or gain of channel function has been associated with dysfunction and aberrant physiology.
Lorena Brito de Souza, Indu Ambudkar
exaly   +3 more sources

TRPC Channels and Neuron Development, Plasticity, and Activities

, 2017
In this chapter, we mainly focus on the functions of TRPC channels in brain development, including neural progenitor proliferation, neurogenesis, neuron survival, axon guidance, dendritic morphology, synaptogenesis, and neural plasticity. We also notice emerging advances in understanding the functions of TRPC channels in periphery, especially their ...
Yilin, Tai, Yichang, Jia
openaire   +3 more sources

Enkurin is a novel calmodulin and TRPC channel binding protein in sperm [PDF]

Developmental Biology, 2004
The TRPC cation channel family has been implicated in receptor- or phospholipase C (PLC)-mediated Ca2+ entry into animal cells. These channels are present in mammalian sperm and are assigned a role in ZP3-evoked Ca2+ influx that drives acrosome reactions.
Harvey Florman, Keith A Sutton, Stephen Lambert   +2 more
exaly   +2 more sources

Expression of canonical transient receptor potential channel (TRPC) 1–7 in the mouse inner ear

Acta Oto-Laryngologica, 2009
Conclusion: It is suggested that TRPCs play a functional role in the sensory cell transduction system in the inner ear. Objective: To study expression of TRPC 1-7 in the mouse inner ear.
Masaya Takumida
exaly   +2 more sources

TRPCs as MS Channels

2007
This chapter reviews recent evidence indicating that canonical or classical transient receptor potential (TRPC) channels are directly or indirectly mechanosensitive (MS) and can therefore be designated as mechano-operated channels (MOCs). The MS functions of TRPCs may be mechanistically related to their better known functions as store-operated and ...
Owen P, Hamill, Rosario, Maroto
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TRPC Channels and Glioma

2017
Glioma is the most common type of brain tumors and malignant glioma is extremely lethal, with patients' 5-year survival rate less than 10%. Treatment of gliomas poses remarkable clinical challenges, not only because of their particular localization but also because glioma cells possess several malignant biological features, including highly ...
Shanshan, Li, Xia, Ding
openaire   +2 more sources