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Functional roles of TRPC channels in the developing brain
Pflügers Archiv - European Journal of Physiology, 2008Transient receptor potential canonical (TRPC) channels are Ca(2+)-permeable, nonselective cation channels formed by homomeric or heteromeric complexes of TRPC proteins that contain six transmembrane domains. These channels can be activated through a phospholipase-C-dependent mechanism, making them sensors for environmental cues. Their expression begins
Yilin, Tai +3 more
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TRPC Channel Modulators and Their Potential Therapeutic Applications
Pharmaceutical Patent Analyst, 2015The transient receptor potential canonical (TRPC) channels have gained interest as potential therapeutic targets for respiratory diseases, neurological disorders, cardiovascular disorders, pain, cancer and several other pathological conditions. The TRPC receptor family consists of seven isoforms (C1-C7) and has been divided into three subfamilies based
Neelima, Khairatkar-Joshi +4 more
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TRPC Channels in Cardiac Hypertrophy
2013Impaired cardiomyocyte Ca2+ handling is considered as crucial factor programming cardiac hypertrophy and heart failure. It has, however, not been entirely resolved what type of Ca2+ signals is involved in mechanisms inducing hypertrophic remodelling.
Nadine Kirschmer +2 more
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TRPC Channel Downstream Signaling Cascades
2017The family of TRP channel is comprised of a large group of cation-permeable channels, displaying as signaling integrators for sensing extracellular stimulus and initiating intracellular signaling cascades. This chapter offers a brief review of the signaling molecules related to TRPC channels, the first identified mammalian TRP family.
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TRPC Channels and Neuron Development, Plasticity, and Activities
2017In this chapter, we mainly focus on the functions of TRPC channels in brain development, including neural progenitor proliferation, neurogenesis, neuron survival, axon guidance, dendritic morphology, synaptogenesis, and neural plasticity. We also notice emerging advances in understanding the functions of TRPC channels in periphery, especially their ...
Yilin, Tai, Yichang, Jia
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Enkurin is a novel calmodulin and TRPC channel binding protein in sperm
Developmental Biology, 2004Harvey Florman +2 more
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TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease
Cells, 2020Falcon D +2 more
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IL-17 induces MIP-1α expression in primary mouse astrocytes via TRPC channel
Inflammopharmacology, 2016Honghong Yao, Jie Chao, Ying Bai
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