Results 51 to 60 of about 7,585 (289)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Increasing Robustness of True Random Number Generators against Attacks

, 2013
Random number generation is a critical issue in numerous cryptographic applications: it is used for generation of initialization vectors, challenges, nonces and confidential keys.
Haddad, Patrick, Teglia, Yannick, Fischer, Viktor, Bernard, Florent   +3 more
core   +1 more source

Locking phenomenon on ring oscillators used in True Random Number Generators

, 2023
International audienceTo ensure the security of electronic devices, true random numbers are required by cryptographic systems. Several True Random Number Generators (TNRG) designs have been proposed, each with different characteritics and implementation ...
Fischer, Viktor, Delolme, Eloïse, Bernard, Florent, Pelcat, Maxime, Lubicz, David   +4 more
core   +5 more sources

Low Cost and Precise Jitter Measurement Method for TRNG Entropy Assessment

Transactions on Cryptographic Hardware and Embedded Systems, 2023
Random number generators and specifically true random number generators (TRNGs) are essential in cryptography. TRNGs implemented in logic devices usually exploit the time instability of clock signals generated in freely running oscillators as source of ...
Florent Bernard, Arturo Garay, Patrick Haddad, Nathalie Bochard, Viktor Fischer   +4 more
doaj   +1 more source

True Random Number Generators on IQM Spark

CoRR
Random number generation is fundamental for many modern applications including cryptography, simulations and machine learning. Traditional pseudo-random numbers may offer statistical unpredictability, but are ultimately deterministic. On the other hand, True Random Number Generation (TRNG) offers true randomness.
Andrzej Gnatowski, Jaroslaw Rudy, Teodor Nizynski, Krzysztof Swiecicki   +3 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Certification of the efficient random number generation technique based on single‐photon detector arrays and time‐to‐digital converters

IET Quantum Communication, 2021
True random number generators (TRNGs) allow the generation of true random bit sequences, guaranteeing the unpredictability and perfect balancing of the generated values.
Andrea Stanco, Davide G. Marangon, Giuseppe Vallone, Samuel Burri, Edoardo Charbon, Paolo Villoresi   +5 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Design and Analysis of Digital True Random Number Generator

, 2013
Random number generator is a key component for strengthening and securing the confidentiality of electronic communications. Random number generators can be divided as either pseudo random number generators or true random number generators.
Yadav, Avantika
core   +1 more source