Results 41 to 50 of about 7,585 (289)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Embedding Tamper-Resistant, Publicly Verifiable Random Number Seeds in Permissionless Blockchain Systems

open access: yesIEEE Access, 2022
Many blockchain processes require pseudo-random numbers. This is especially true of blockchain consensus mechanisms that aim to fairly distribute the opportunity to propose new blocks between the participants in the system.
Riaan Bezuidenhout   +2 more
doaj   +1 more source

FPGA Vendor Agnostic True Random Number Generator [PDF]

open access: yes2006 International Conference on Field Programmable Logic and Applications, 2006
This paper describes a solution for the generation of true random numbers in a purely digital fashion; making it suitable for any FPGA type, because no FPGA vendor specific features (e.g., like phase-locked loop) or external analog components are required.
Dries Schellekens   +2 more
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Always Metastable State True Random Number Generator [PDF]

open access: yesJournal of information and communication convergence engineering, 2012
This paper presents an efficient filtering system for a metastable state-based true random number generator. To output a result with high randomness, we use loop-storage for storing the value of metastability. During the metastable state, the output value is accumulated to the storage.
Hwajeong Seo, Howon Kim 0001
openaire   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

EEG-Based random number generators

open access: yes, 2017
In this paper, we propose a new method that transforms electroencephalogram (EEG) signal and its wave bands into sequences of bits that can be used as a random number generator.
Nguyen, Khoa   +7 more
core   +1 more source

Reliability Analysis of Random Telegraph Noisebased True Random Number Generators

open access: yes, 2023
The diffusion of Internet of Things (IoT) and edge computing poses several security challenges and demands the development of security primitives implemented at the hardware level.
Ranjan, Alok,   +6 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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