Results 61 to 70 of about 7,585 (289)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

True Random Number Generator (TRNG) Utilizing FM Radio Signals for Mobile and Embedded Devices in Multi-Access Edge Computing

Sensors, 2019
As transmissions of data between mobile and embedded devices in multi-access edge computing (MEC) increase, data must be protected, ensuring confidentiality and integrity.
Kyungroul Lee, Manhee Lee
doaj   +1 more source

Reconfigurable Physically Unclonable Functions Based on Nanoscale Voltage‐Controlled Magnetic Tunnel Junctions

Advanced Electronic Materials, 2023
With the fast growth of the number of electronic devices on the internet of things (IoT), hardware‐based security primitives such as physically unclonable functions (PUFs) have emerged to overcome the shortcomings of conventional software‐based ...
Yixin Shao, Noraica Davila, Farbod Ebrahimi, Jordan A. Katine, Giovanni Finocchio, Pedram Khalili Amiri   +5 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

A True Random Number Generator Based on Gait Data for the Internet of You

IEEE Access, 2020
The Internet of Things (IoT) is more and more a reality, and every day the number of connected objects increases. The growth is practically exponential -there are currently about 8 billion and expected to reach 21 billion in 2025.
Carmen Camara, Honorio Martin, Pedro Peris-Lopez, Luis Entrena   +3 more
doaj   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Memristive True Random Number Generator for Security Applications

Sensors
This study explores memristor-based true random number generators (TRNGs) through their evolution and optimization, stemming from the concept of memristors first introduced by Leon Chua in 1971 and realized in 2008. We will consider memristor TRNGs coming from various entropy sources for producing high-quality random numbers. However, we must take into
Xianyue Zhao, Li-Wei Chen 0001, Kefeng Li, Heidemarie Schmidt, Ilia Polian, Nan Du 0004   +5 more
openaire   +4 more sources

On the Security of Chaos Based “True” Random Number Generators

IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences, 2016
This paper deals with the security of chaos-based "true" random number generators (RNG)s. An attack method is proposed to analyze the security weaknesses of chaos-based RNGs and its convergence is proved using a master slave synchronization scheme. Attack on a RNG based on a double-scroll attractor is also presented as an example. All secret parameters
openaire   +2 more sources