Results 51 to 60 of about 19,762 (209)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Relationships Among Supervisors’ Authentic Leadership, Ostracism, Perceived Supervisor’s Trust and Commitment to Customer Services: Evidence From Frontline Service Employees of Small Stores

SAGE Open
The influential roles of supervisor’s leadership in the context of a small store are not studied and it is unclear how it affects the attitudinal and behavioral outcomes of frontline service employees.
Ihsan Ullah Jan, Seonggoo Ji
doaj   +1 more source

Examining the dimensions of incivility in the workplace on the mastery of individual tasks and individual work adaptation through the mediating role of trust in the supervisor among the employees of the General Department of Education in Gilan provin [PDF]

پژوهش‌های رهبری آموزشی
Today, due to the necessity of social changes, education is considered one of the complex and large organizations in any country, and its fruitfulness is, on the one hand, turning gifted people into balanced and developed people, and on the other hand ...
Seyed Hamed Hashemi, Mona Panahi
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Designing and testing a model of some antecedents of happiness at work in employees of Foolad Ghab Asia Company

مشاوره شغلی و سازمانی, 2020
The purpose of this study was designing and testing a model of some antecedents of happiness at work. The sample consisted of 322 employees of Foolad Ghab Asia Company who was selected by stratified random sampling.
نسرین ارشدی, امیر فردوسی زاده, عبدالکاظم نیسی   +2 more
doaj  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

LIDERAZGO TRANSFORMADOR Y SATISFACCIÓN LABORAL: EL ROL DE LA CONFIANZA EN EL SUPERVISOR / TRANSFORMATIONAL LEADERSHIP AND JOB SATISFACTION: THE ROLE OF TRUSTING IN THE SUPERVISOR [PDF]

Liberabit, 2011
RESUMENEl objetivo de la presente investigación fue analizar las posibles relaciones entre la satisfacción laboral y las percepcionesdel supervisor como un líder transformador, así como verificar el papel de la confianza sobre tales relaciones.
Alicia Omar*
doaj  

Authentic leadership and organisational citizenship behaviour in the public health care sector: The role of workplace trust

SA Journal of Industrial Psychology, 2016
Orientation: The orientation of this study was towards authentic leadership and its influence on workplace trust and organisational citizenship behaviour in the public health care sector.
Lynelle Coxen, Leoni van der Vaart, Marius W. Stander   +2 more
doaj   +1 more source