Results 71 to 80 of about 400 (115)

Molecular Dynamics Simulations to Investigate How PZM21 Affects the Conformational State of the μ-Opioid Receptor Upon Activation. [PDF]

Int J Mol Sci, 2020
Zhao Z, Huang T, Li J.
europepmc   +1 more source

Faculty Opinions recommendation of APOLLO-2: A Randomized, Placebo and Active-Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein-Biased Ligand at the μ-Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2021
openaire   +2 more sources

Ligand-Induced Biased Activation of GPCRs: Recent Advances and New Directions from In Silico Approaches. [PDF]

Molecules
Hashem S, Dougha A, Tufféry P.
europepmc   +1 more source

Mechanism of β-arrestin recruitment by the μ-opioid G protein-coupled receptor. [PDF]

Proc Natl Acad Sci U S A, 2020
Mafi A, Kim SK, Goddard WA.
europepmc   +1 more source

Atomic-Level Characterization of the Methadone-Stabilized Active Conformation of µ-Opioid Receptor. [PDF]

Mol Pharmacol, 2020
Kapoor A, Provasi D, Filizola M.
europepmc   +1 more source

Deciphering complexity of GPCR signaling and modulation: implications and perspectives for drug discovery. [PDF]

Clin Sci (Lond)
Costa-Neto CM, Parreiras-E-Silva LT.
europepmc   +1 more source

Biased agonism in psychopharmacology: an opportunity to improve efficacy and safety of treatments. [PDF]

CNS Spectr
Le GH, Wong S, Bargiota S, Jennifer S, Lo HKY, Orsini D, Teopiz K, Guillen-Burgos HF, Lim PK, McIntyre RS.   +9 more
europepmc   +1 more source

<i>OpenMMDL</i> - Simplifying the Complex: Building, Simulating, and Analyzing Protein-Ligand Systems in <i>OpenMM</i>. [PDF]

J Chem Inf Model
Talagayev V, Chen Y, Doering NP, Obendorf L, Denzinger K, Puls K, Lam K, Liu S, Wolf CA, Noonan T, Breznik M, Knaus P, Wolber G.   +12 more
europepmc   +1 more source

Comparison of the reinforcing, antinociceptive, and respiratory depressant effects of prototypical and G-protein biased mu-opioid receptor agonists in male and female Sprague-Dawley rats. [PDF]

Psychopharmacology (Berl)
Zamarripa CA, Pareek T, Pham LM, Blough BE, Schrock HM, Vallender EJ, Sufka KJ, Freeman KB.   +7 more
europepmc   +1 more source

Intracellular Pocket Conformations Determine Signaling Efficacy through the μ Opioid Receptor. [PDF]

J Chem Inf Model
Cooper DA, DePaolo-Boisvert J, Nicholson SA, Gad B, Minh DDL.   +4 more
europepmc   +1 more source