Results 81 to 90 of about 400 (115)

Bunionectomy as an Acute Postoperative Pain Model: Overview of Common Experimental Methods, and Insights from Past Clinical Trials. [PDF]

J Pain Res
Singla N, Rogier T, Meske DS.
europepmc   +1 more source

Faculty Opinions recommendation of Can oliceridine (TRV130), an ideal novel µ receptor G protein pathway selective (µ-GPS) modulator, provide analgesia without opioid-related adverse reactions?

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2018
openaire   +2 more sources

Effects of Oliceridine Versus Sufentanil on Hemodynamic Stability in Elderly Hypertensive Patients During Laryngeal Mask Airway Anesthesia: A Randomized Controlled Trial. [PDF]

Drug Des Devel Ther
Chen L, Xie K, Ji K, Long M, Zhang Y, He K.   +5 more
europepmc   +1 more source

Efficacy, safety, and side effects of oliceridine in acute postoperative pain, a protocol for a systematic review and meta-analysis. [PDF]

PLoS One
Wolf A, Unterberg M, Witowski A, Adamzik M, Wolf A.   +4 more
europepmc   +1 more source

The c-Src inhibitor eCF506 diminishes opioid tolerance creating bias against β-arrestin2 recruitment

Singleton S, Nunn F, Lace E, Lorente-Macías Á, Toth R, Unciti-Broceta A, Hales TG.   +6 more
europepmc   +1 more source

Identification of Spiro[chromene-2,4'-piperidine]s as Potent, Selective, and G_q-Biased 5-HT_2C Receptor Partial Agonists. [PDF]

ACS Med Chem Lett
Jiang G, Zhang B, Zhang X, Chen F, Qin W, Chen JL, Tian S, Shui W, Ye N.   +8 more
europepmc   +1 more source

Rational Design Biased Compounds against μ‑Opioid Receptor. [PDF]

ACS Pharmacol Transl Sci
Wu C, Li Y, Vogel H, Yuan S.
europepmc   +1 more source

Effect of Oliceridine Fumarate for Patient-Controlled Intravenous Analgesia on Gastrointestinal Function in Laparoscopic Radical Gastrectomy Surgery: A Randomized, Double-Blind, Controlled Trial. [PDF]

Drug Des Devel Ther
Wang C, Xu WD, Lu XL, Lei WP, Sun JL, Huang YQ.   +5 more
europepmc   +1 more source

Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics

Neuropharmacology, 2020
Binding and signaling kinetics have previously proven important in validation of biased agonism at GPCRs. Here we provide a comprehensive kinetic pharmacological comparison of clinically relevant μ-opioid receptor agonists, including the novel biased agonist oliceridine (TRV130) which is in clinical trial for pain management.
Emil Marcher-Rørsted, Daniel Sejer Pedersen, Thor C Møller   +2 more
exaly   +6 more sources

Approval of oliceridine (TRV130) for intravenous use in moderate to severe pain in adults [PDF]

British Journal of Anaesthesia, 2020
EditordOpioids used for the treatment of moderate to severe pain in an appropriate setting with appropriate management (stewardship) have good efficacy. However, when these are used long term their efficacy is questionable. Tolerance develops leading to escalating doses and a vicious circle of side-effects.
David G Lambert, Girolamo Calò
exaly   +5 more sources