Results 151 to 160 of about 3,404 (180)
Some of the next articles are maybe not open access.
Analytical and Bioanalytical Chemistry, 2014
The chromatographic isolation and characterisation of the four compounds present in the quaternary phenanthridine veterinary trypanocidal agent, isometamidium chloride hydrochloride (ISM), is reported. The isolated compounds were unambiguously characterised using spectroscopic (NMR, UV, IR and MS) methods as 3-amino-8-[3-(3-carbamimidoyl-phenyl ...
John O, Igoli +6 more
openaire +2 more sources
The chromatographic isolation and characterisation of the four compounds present in the quaternary phenanthridine veterinary trypanocidal agent, isometamidium chloride hydrochloride (ISM), is reported. The isolated compounds were unambiguously characterised using spectroscopic (NMR, UV, IR and MS) methods as 3-amino-8-[3-(3-carbamimidoyl-phenyl ...
John O, Igoli +6 more
openaire +2 more sources
Novel fluorinated quaternary ammonium salts and their in vitro activity as trypanocidal agents
Medicinal Chemistry Research, 2019As the impact of aromatic rings and fluorine substituents in commercial drugs is attributed to their electronic distribution and structure rigidity that determine metabolic stability and toxicity, 30 quaternary ammonium salts (QAS) of the form [X-CH2N(CH3)2(CH2)nCH = C(Ar2)]+I− (where X=H, Cl or I, n = 2 or 3, and Ar = m-C6H4CF3, p-C6H4CF3, m-C6H4F, p ...
Marisol López-Muñoz +7 more
openaire +1 more source
Chemico-Biological Interactions, 2003
This study has investigated the effect of phenobarbitone (PB), 3-methylcholanthrene (3-MC), and deltamethrin (DM) on the metabolism of two trypanocidal diamidines; pentamidine isethionate and diminazene aceturate in freshly isolated Sprague-Dawley rat hepatocytes.
Atsriku, C. +3 more
openaire +3 more sources
This study has investigated the effect of phenobarbitone (PB), 3-methylcholanthrene (3-MC), and deltamethrin (DM) on the metabolism of two trypanocidal diamidines; pentamidine isethionate and diminazene aceturate in freshly isolated Sprague-Dawley rat hepatocytes.
Atsriku, C. +3 more
openaire +3 more sources
Influence of Pentamidine and Two New Trypanocidal Agents (DAPI, DIPI) on Liver Metabolism of Mice
Pharmacology & Toxicology, 1991Abstract:The effects of equimolar doses (65.5 μmol/kg intraperitoneally) of three trypanocidal compounds, i.e. pentamidine, 6‐amidino‐2‐(amidinophenyl)indole (DAPI), and 6‐imidazolino‐2‐(imidazolinophenyl)indole (DIPI) on some parameters of liver carbohydrate, lipid and energy metabolism have been assessed in male NMRI mice. Most prominent effects were
H, Sippel, U, Steinmann, C J, Estler
openaire +2 more sources
[Plasma kinetics of a spiroarsorane trypanocidal agent in sheep trypanosomiasis].
Bulletin de la Societe de pathologie exotique (1990), 1990In a previous study, spiroarsoranes were very effective against both the two pathogenic phases of the experimental sheep trypanosomiasis. In this paper, the authors had studied the plasmatic pharmacokinetics of these compounds. Data had shown one peak 10 min after injection of a 3 months inoculated sheep, and 90 min for the control sheep. Spiroarsorane
G, Dreyfuss +4 more
openaire +1 more source
Synthesis and in vitro trypanocidal activity of some novel iron chelating agents.
Arzneimittel-Forschung, 1997This report describes the syntheses and in vitro trypanocidal activity of a number of iron (III) chelators against epimastigotes of Trypanosoma cruzi. The compounds examined included a number of lipophilic N-alkyl derivatives of 2-ethyl- and 2-methyl-3-hydroxypyrid-4-ones, N,N'-bis(o-hydroxybenzyl)-(+/-)-trans-1,2-diaminocyclohexane ...
P K, Singh +8 more
openaire +1 more source
Molecular imaging in oncology: Current impact and future directions
Ca-A Cancer Journal for Clinicians, 2022Steven P Rowe, Martin G Pomper
exaly
Treatment of muscle‐invasive and advanced bladder cancer in 2020
Ca-A Cancer Journal for Clinicians, 2020Vaibhav G Patel +2 more
exaly