Results 161 to 170 of about 7,490 (202)

Short versus long drug regimens for Chagas disease. [PDF]

Cochrane Database Syst Rev
Díaz Menai S, Varela LB, Escobar Liquitay CM, Santero M, Bracchiglione J, Garegnani L.   +5 more
europepmc   +1 more source

Easy Obtainment and Biological Applicability of Pinocarvyl Acetate by Encapsulating of the <i>Microlicia graveolens</i> Essential Oil in Oil-in-Water Nanoemulsions. [PDF]

Pharmaceutics
Seibert JB, Amparo TR, Sousa LRD, Rodrigues IV, Petit A, Pervier P, Azevedo MC, Sales Junior PA, Murta SMF, Carneiro CM, Teixeira LFM, de Souza GHB, Vieira PMA, Santos ODHD.   +13 more
europepmc   +1 more source

Recent Progress in Thiazole, Thiosemicarbazone, and Semicarbazone Derivatives as Antiparasitic Agents Against Trypanosomatids and <i>Plasmodium</i> spp. [PDF]

Molecules
Souza Tada da Cunha P, Rodriguez Gini AL, Man Chin C, Dos Santos JL, Benito Scarim C.   +4 more
europepmc   +1 more source

Antiproliferative and Trypanocidal Activity of Ivermectin Bioconjugates. [PDF]

ACS Omega
Sulik M, Otto-Ślusarczyk D, Steverding D, Struga M, Huczyński A.   +4 more
europepmc   +1 more source

Overview of the chemotherapy research program at ILRAD

, 2010
Aliu, Y.O., Codjia, V., D'Ieteren, G.D.M., Gray, M.A., Jamnadass, Ramni H., Mamman, M., Moloo, S.K., Murphy, N.B., Mutharia, L., Peregrine, A.S., Silayo, R., Sutherland, I.A.   +11 more
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Methylating agents as trypanocides

Journal of Medicinal Chemistry, 1990
Methylating agents, such as streptozotocin, procarbazine, N-methyl-N-nitrosourea, dimethyl sulfate, 1,2-dimethylhydrazine, and a series of 1,2-bis(sulfonyl)-1-methylhydrazines synthesized in this laboratory, were evaluated and shown to be therapeutically active against murine models of African trypanosomiasis.
P G, Penketh, K, Shyam, A A, Divo, C L, Patton, A C, Sartorelli   +4 more
openaire   +2 more sources

Synthesis of New Trypanocidal Agents from the Hybridisation of Metronidazole and Eugenol Analogues

Bioorganic Chemistry, 2023
Nitroimidazole compounds are well-known bioactive substances, and the structural activity relationship has been reported whereby the position of the nitro group within the imidazole ring has a large influence on the activity. This study focuses on synthesising new trypanocidal agents from the hybridisation of metronidazole with different natural ...
Mônica Fraccarolli Pelozo, Cleydson Finotti Cordeiro, Letícia Fonseca Inácio, Rayssa de Cassia Alves Lemini, Elda Gonçalves Souza e Leite, Monique Dias Benedetti, Cristiane Alves Tulha, Rômulo Dias Novaes, Ivo Santana Caldas, Diogo Teixeira Carvalho, Stefânia Neiva Lavorato, Jamie Anthony Hawkes, Lucas Lopardi Franco   +12 more
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Synthesis of sydnonimine derivatives as potential trypanocidal agents

Journal of Heterocyclic Chemistry, 2003
AbstractN‐(p‐Nitrophenoxy)carbonyl‐3‐morpholino‐sydnonimine (NCMS) has been prepared from 3‐morpholinosydnonimine hydrochloride. Using the Griess assay and the superoxide‐mediated reduction of ferricytochrome c, the nitric oxide (NO•) and superoxide anion (O2•‐) ‐ releasing properties in phosphate buffer pH 7.4 of this novel peroxynitrite donor was ...
Laurent Soulere, Frederic Bringaud, Pascal Hoffmann   +2 more
openaire   +1 more source

Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents

Bioorganic & Medicinal Chemistry Letters, 2006
The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b.
Julieta, Coro, Richard, Atherton, Susan, Little, Hayley, Wharton, Vanessa, Yardley, Amaury, Alvarez, Margarita, Súarez, Rolando, Pérez, Hortensia, Rodríguez   +8 more
openaire   +2 more sources

Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents

Journal of Medicinal Chemistry, 1990
Several 1,2,2-tris(sulfonyl)hydrazines, conceived as prodrugs of 1,2-bis(sulfonyl)hydrazines, were synthesized and evaluated for antineoplastic and trypanocidal activities in mice. 1-Methyl-1,2,2-tris(methylsulfonyl)hydrazine emerged as an extremely efficacious antitrypanosomal agent, whereas 1-(2-chloroethyl)-1,2,2-tris(methylsulfonyl)hydrazine was ...
K, Shyam, P G, Penketh, A A, Divo, R H, Loomis, C L, Patton, A C, Sartorelli   +5 more
openaire   +2 more sources