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1,3,4-oxadiazoles as inhibitors of the atypical member of the BET family bromodomain factor 3 from Trypanosoma cruzi (TcBDF3). [PDF]

Front Microbiol
Alonso VL, Escalante AM, Rodríguez Araya E, Frattini G, Tavernelli LE, Moreno DM, Furlan RLE, Serra E.   +7 more
europepmc   +1 more source

3'-deoxytubercidin: A potent therapeutic candidate for the treatment of Surra and Dourine. [PDF]

Int J Parasitol Drugs Drug Resist
Ilbeigi K, Mabille D, Roy R, Bundschuh M, Van de Velde E, Hulpia F, Van Calenbergh S, Caljon G.   +7 more
europepmc   +1 more source

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Trypanocidal treatment of Chagas disease

Enfermedades infecciosas y microbiologia clinica (English ed.), 2021
Chagas disease is a neglected parasitosis caused by the protozoan parasite Trypanosoma cruzi. This infection is present in most Latin American countries, although, due to migratory movements, it is a growing cause for concern in non-endemic countries. The only two drugs currently available for its treatment-benznidazole and nifurtimox-were marketed 50 ...
Jose A, Pérez-Molina, Clara, Crespillo-Andújar, Pau, Bosch-Nicolau, Israel, Molina   +3 more
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Methylating agents as trypanocides

Journal of Medicinal Chemistry, 1990
Methylating agents, such as streptozotocin, procarbazine, N-methyl-N-nitrosourea, dimethyl sulfate, 1,2-dimethylhydrazine, and a series of 1,2-bis(sulfonyl)-1-methylhydrazines synthesized in this laboratory, were evaluated and shown to be therapeutically active against murine models of African trypanosomiasis.
P G, Penketh, K, Shyam, A A, Divo, C L, Patton, A C, Sartorelli   +4 more
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Metamidium: a New Trypanocidal Drug

Nature, 1958
THIS communication describes a new trypanocide, which has been found to possess considerable potentiality as a curative and as a prophylactic drug, both in laboratory experiments and in field trials carried out in Africa during the past year.
W R, WRAGG, K, WASHBOURN, K N, BROWN, J, HILL   +3 more
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IMOL 881, a new trypanocidal compound

Acta Tropica, 1993
A new drug molecule (IMOL 881) was synthesized and is showing interesting trypanocidal properties. The test results on animal models indicate activity against several trypanosome species, both in the veterinary and in the human medicine application fields. The species tested so far include: T. evansi, T. equiperdum, T. gambiense and T. rhodesiense. The
L, Maes, E B, Songa, R, Hamers
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Trypanocidal Sesquiterpenes fromLychnophora Species

Phytotherapy Research, 1996
The bioguided fractionation of the crude extracts of Lychnophora passerina (Mart. ex DC) Gardn., L. pinaster Mart. and L. trichocarpha Spreng. led to the isolation of four compounds active against the trypomastigote forms of Trypanosoma cruzi: the sesquiterpene lactones goyazensolide (1), eremantholide C (2), and lychnopholide (3) and a new ...
Alaíde B. de Oliveira, Dênia A. Saúde, Katia S. P. Perry, Dâmaris S. Duarte, Délio S. Raslan, Maria Amélia D. Boaventura, Egler Chiari   +6 more
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TRYPANOCIDE.

The Lancet, 1921
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NEW TRYPANOCIDAL SUBSTANCES

The Lancet, 1937
H. King, E.M. Lourie, Warrington Yorke
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Synthesis of Potential Trypanocides

1987
Abstract : This report describes the synthesis of new compounds for evaluation as antiparasitic agents. Most of the biological data pertain to activity against Trypanosoma rhodesiense but limited data pertaining to leishmania, filarius and plasmodium are also included. Biological data is included for compounds prepared in an earlier contract. The salts
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