Results 141 to 150 of about 944 (184)
A cell surface transporter mediates phenanthridine resistance in African trypanosomes
Steketee PC +11 more
europepmc +1 more source
Biosynthesis of a trypanocide by Chromobacterium violaceum
World Journal of Microbiology and Biotechnology, 1994 Radio-isotope studies indicated not only that L-tryptophan can serve as carbon source for synthesis of the trypanocide, violacein by Chromobacterium violaceum (BB-78 strain) but also that isatin and indole 3-acetic acid are both important metabolic intermediates.
Marcela Haun +2 more
exaly +4 more sources
Pharma to farmer: field challenges of optimizing trypanocide use in African animal trypanosomiasis [PDF]
Trends in Parasitology, 2021 Trypanocides are a key control component of African animal trypanosomiasis (AAT) in tsetse-infested areas of sub-Saharan Africa. While farmers are dependent upon trypanocides, recent research highlights their inappropriate and ineffective use, problems ...
Shauna Richards +2 more
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Trypanocidal treatment of Chagas disease
Enfermedades infecciosas y microbiologia clinica (English ed.), 2021Chagas disease is a neglected parasitosis caused by the protozoan parasite Trypanosoma cruzi. This infection is present in most Latin American countries, although, due to migratory movements, it is a growing cause for concern in non-endemic countries. The only two drugs currently available for its treatment-benznidazole and nifurtimox-were marketed 50 ...
Jose A, Pérez-Molina +3 more
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Methylating agents as trypanocides
Journal of Medicinal Chemistry, 1990Methylating agents, such as streptozotocin, procarbazine, N-methyl-N-nitrosourea, dimethyl sulfate, 1,2-dimethylhydrazine, and a series of 1,2-bis(sulfonyl)-1-methylhydrazines synthesized in this laboratory, were evaluated and shown to be therapeutically active against murine models of African trypanosomiasis.
P G, Penketh +4 more
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Xenobiotica, 1999 Confocal laser scanning microscopy (CLSM) has shown that ethidium (3, 8-diamino-5-ethyl-6-phenylphenanthridinium) bromide, an aromatic phenanthridinium trypanocide, is taken up rapidly into the nucleoli and nuclear membranes of isolated rat hepatocytes ...
G G Skellern, M H Grant, Andrew R Pitt
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Metamidium: a New Trypanocidal Drug
Nature, 1958THIS communication describes a new trypanocide, which has been found to possess considerable potentiality as a curative and as a prophylactic drug, both in laboratory experiments and in field trials carried out in Africa during the past year.
W R, WRAGG +3 more
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STANDARDIZATION OF THE TRYPANOCIDAL TEST AND OF THE TRYPANOCIDAL VALUE OF ARSPHENAMINE
Archives of Dermatology and Syphilology, 1928The therapeutic value of arsphenamine was established by Ehrlich and Hata 1 as a result of experiments on various animals (mice, rats, chickens and rabbits) inoculated with syphilis, trypanosomiasis, chicken spirillosis and recurrent fever. The nature of these diseases is such as to permit of a more or less direct observation of the effect of the drug ...
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Trypanocidal effects of catecholamines and indolealkylamines
Annals of Tropical Medicine & Parasitology, 1990Catecholamines, indolealkylamines and their analogues are oxidized at neutral or alkaline pH, producing hydrogen peroxide, quinones and free radicals. Several of these amines were tested for trypanocidal effects on Trypanosoma brucei, which possess a well-documented vulnerability to such oxidation products.
O A, Owolabi +3 more
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