Results 121 to 130 of about 640 (163)
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Trypanocidal treatment of Chagas disease
Enfermedades infecciosas y microbiologia clinica (English ed.), 2021Chagas disease is a neglected parasitosis caused by the protozoan parasite Trypanosoma cruzi. This infection is present in most Latin American countries, although, due to migratory movements, it is a growing cause for concern in non-endemic countries. The only two drugs currently available for its treatment-benznidazole and nifurtimox-were marketed 50 ...
Jose A, Pérez-Molina +3 more
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Biosynthesis of a trypanocide by Chromobacterium violaceum
World Journal of Microbiology and Biotechnology, 1994Radio-isotope studies indicated not only that L-tryptophan can serve as carbon source for synthesis of the trypanocide, violacein by Chromobacterium violaceum (BB-78 strain) but also that isatin and indole 3-acetic acid are both important metabolic intermediates.
Nelson Durán +2 more
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Methylating agents as trypanocides
Journal of Medicinal Chemistry, 1990Methylating agents, such as streptozotocin, procarbazine, N-methyl-N-nitrosourea, dimethyl sulfate, 1,2-dimethylhydrazine, and a series of 1,2-bis(sulfonyl)-1-methylhydrazines synthesized in this laboratory, were evaluated and shown to be therapeutically active against murine models of African trypanosomiasis.
P G, Penketh +4 more
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STANDARDIZATION OF THE TRYPANOCIDAL TEST AND OF THE TRYPANOCIDAL VALUE OF ARSPHENAMINE
Archives of Dermatology and Syphilology, 1928The therapeutic value of arsphenamine was established by Ehrlich and Hata 1 as a result of experiments on various animals (mice, rats, chickens and rabbits) inoculated with syphilis, trypanosomiasis, chicken spirillosis and recurrent fever. The nature of these diseases is such as to permit of a more or less direct observation of the effect of the drug ...
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Metamidium: a New Trypanocidal Drug
Nature, 1958THIS communication describes a new trypanocide, which has been found to possess considerable potentiality as a curative and as a prophylactic drug, both in laboratory experiments and in field trials carried out in Africa during the past year.
W R, WRAGG +3 more
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Trypanocidal effects of catecholamines and indolealkylamines
Annals of Tropical Medicine & Parasitology, 1990Catecholamines, indolealkylamines and their analogues are oxidized at neutral or alkaline pH, producing hydrogen peroxide, quinones and free radicals. Several of these amines were tested for trypanocidal effects on Trypanosoma brucei, which possess a well-documented vulnerability to such oxidation products.
O A, Owolabi +3 more
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Note on Bismuth as a Trypanocide
Annals of Tropical Medicine and Parasitology, 1921S Adler
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The Trypanocidal Effect of Nucleocidin In vivo
The Journal of Parasitology, 1957During the past few years the first reports have been made of antibiotics which are effective against trypanosomes in vivo. McCowan et al (1953) reported that erythromycin prevented death of mice infected with Trypanosoma equiperdum. Hewitt et al (1953) found that puromycin (Stylomycin) was effective against T. equiperdum and T.
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Synthesis of Potential Trypanocides
1987Abstract : This report describes the synthesis of new compounds for evaluation as antiparasitic agents. Most of the biological data pertain to activity against Trypanosoma rhodesiense but limited data pertaining to leishmania, filarius and plasmodium are also included. Biological data is included for compounds prepared in an earlier contract. The salts
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