Results 101 to 110 of about 101,216 (253)

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several anti-trypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
Schnaufer, Achim; id_orcid, Gould, Matthew K   +1 more
core   +1 more source

Peridomestic infestation by Triatoma pallidipennis and natural infection with Trypanosoma cruzi in Zacatepec, Morelos, Mexico Infestación peridoméstica por Triatoma pallidipennis e infección natural por Trypanosoma cruzi en Zacatepec, Morelos, México

Medical and Veterinary Entomology, EarlyView.
Entomological and community‐related risk factors for Chagas disease were assessed through peridomestic sampling, calculation of entomological indices and surveys of community knowledge, attitudes and practices. Forty‐six triatomines, all identified as Triatoma pallidipennis, were collected, and all specimens showed natural infection with Trypanosoma ...
Reyna Vargas‐Abasolo, José Rafael Delgado López, Liliana Aguilar‐Marcelino, Miguel Galarde‐López, Gemma Rojo, Alex Córdoba‐Aguilar   +5 more
wiley   +1 more source

Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development [PDF]

, 2005
It is well established that genetic exchange occurs between Trypanosoma brucei parasites when two stocks are used to infect tsetse flies under laboratory conditions and a number of such crosses have been undertaken.
Turner, C.M.R., Tait, A., Tweedie, A., Masiga, D., MacLeod, A.   +4 more
core   +1 more source

Plant NAOGAT (ArgJ) Structure Reveals Mechanism of Ornithine Biosynthesis, Preference for Acetylornithine and Susceptibility to Mangotoxin

Plant, Cell &Environment, EarlyView.
ABSTRACT Arginine metabolism in plants is targeted by phytopathogens such as Pseudomonas syringae strains, which produce toxins that affect enzymes of plant arginine metabolism, causing devastating infections in crops. In this work, the structural and functional properties of plant N‐acetylornithine glutamate acetyltransferase (NAOGAT), the key ...
Maciej Nielipinski, Agnieszka J. Pietrzyk‐Brzezinska, Aleksandra Twarda‐Clapa, Bartosz Sekula   +3 more
wiley   +1 more source

The kinetoplast DNA of the Australian trypanosome, Trypanosoma copemani, shares features with Trypanosoma cruzi and Trypanosoma lewisi

International Journal for Parasitology, 2018
Kinetoplast DNA (kDNA) is the mitochondrial genome of trypanosomatids. It consists of a few dozen maxicircles and several thousand minicircles, all catenated topologically to form a two-dimensional DNA network. Minicircles are heterogeneous in size and sequence among species.
Botero, Adriana, Kapeller, Irit, Cooper, Crystal, Clode, Peta L., Shlomai, Joseph, Thompson, R.C. Andrew   +5 more
openaire   +3 more sources

Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species [PDF]

, 2012
Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and ...
Browne, H., Jackson, Andrew P., Marcello, Lucio, Jackson, A.P., Jackson, A. P., Quail, M. A., Ginger, M. L., Marcello, L., Quail, M.A., Berriman, Matthew, Jackson, Andrew P, Berry, Andrew, Field, M. C., Aslett, Martin, Sanders, Mandy J., McQuillan, J., Barry, J. David, Field, Mark C., Allinson, Harriet C., Browne, Hilary, Hauser, H., Aslett, M., Barry, J.D., Burton, Peter, Allison, Harriet C., Ginger, Michael L., Gilderthorp, Ruth, Berry, A., van Tonder, Andries, Allison, H.C., McQuillan, Jacqueline, Burton, P., Ginger, M.L., Corton, Nicola, Gilderthorp, R., Hertz-Fowler, Christiane, Field, M.C., Field, MarkC., Corton, N., Quail, Michael A., Gamble, John, Brown, R., Otto, Thomas D., Otto, T. D., Barry, J. D., Gamble, J., Hauser, Heidi, Hertz-Fowler, C., Brown, Robert, van Tonder, A., Berriman, M., Ginger, Michael, Vavrova-Anderson, Jana, Vavrova-Anderson, J., Sanders, M.J., Allison, H. C., Hertz-Fowler, Christine, Otto, T.D., Sanders, M. J.   +58 more
core   +1 more source

Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids.

, 2005
Trypanosoma cruzi, the causative agent of Chagas disease, has at least two principal intraspecific subdivisions, T. cruzi I (TCI) and T. cruzi II (TCII), the latter containing up to five subgroups (a-e).
González, N., Arias, A. R.de, de Arias, Antonieta Rojas, Acosta, Nidia, González, Nilsa, Miles, M.A., Miles, G.A.J., Patterson, J.S., Sánchez, Humberto, Yeo, M., Patterson, James S, Acosta, N., Sánchez, H., Miles, Graham AJ, Yeo, Matthew, López, Elsa, Miles, Michael A, Gaunt, M.W., López, E., Adamson, Susie, Adamson, S., Gaunt, Michael W, Llewellyn, Martin, Llewellyn, M.S.   +23 more
core   +1 more source

An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei [PDF]

, 2015
Elucidating the mechanism of action of trypanocidal compounds is an important step in the development of more efficient drugs against Trypanosoma brucei. In a screening approach using an RNAi library in T. brucei bloodstream forms, we identified a member
Vial, Henri, Niemann, Moritz, de Macêdo, Juan P., Isabel Roditi, Henri Vial (24552), Moritz Niemann, Mäser, Pascal, Juan P. de Macêdo (735541), Bütikofer, Peter, Barrett, Michael P., Michael P Barrett, Gabriela Schumann Burkard (259590), Pascal Mäser (87895), Peter Bütikofer, Moritz Niemann (735542), Pascal Mäser, Horn, David, André Schneider (74039), Juan P de Macêdo, Isabel Roditi (60386), André Schneider, Roditi, Isabel, Schumann Burkard, Gabriela, Henri Vial, Schneider, André, Schumann-Burkard, Gabriela, Gabriela Schumann Burkard, Michael P. Barrett (167748), Peter Bütikofer (147146)   +28 more
core   +3 more sources

Assessment of the Binding Affinity of Covalent Inhibitors of Cruzain and Cathepsin L Using Relative Binding Free Energy

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Six nitrile‐based covalent inhibitors are evaluated against cruzain and hCatL. Thermodynamic integration accurately predicts relative binding affinities by modeling the covalent adduct state. We identify a structural difference in the S2 subsite that governs ligand selectivity, offering valuable insights for drug discovery.
Yan Carvalho Magno, Luiz Fernando Barbosa, Maycon Vinicius Damasceno de Oliveira, Jerônimo Lameira, Carlos A. Montanari   +4 more
wiley   +1 more source

Trypanosoma brucei

Trends in Parasitology, 2020
Gabriela, Romero-Meza, Monica R, Mugnier
openaire   +3 more sources