Results 121 to 130 of about 101,216 (253)
Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva +10 more
wiley +1 more source
Validating Wing Biopsies for Blood‐Borne Pathogen Characterization in Bats
Molecular Ecology, Volume 35, Issue 19, October 2026.ABSTRACT Wildlife surveillance is critical for tracking disease emergence, characterizing pathogen diversity, and assessing spillover risks. Blood‐borne pathogens are of particular interest for such efforts due to their global distribution, broad host taxa, and zoonotic potential.
Molly C. Simonis +9 more
wiley +1 more source
ParasitologyBees are key species for pollination and apiculture. Within the multiple biotic threats, parasites are one of the main players involved in bee health. Among them, trypanosomatid parasites have been the focus of recent studies that have placed them as one
Pedro García Olmedo +8 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 18, 28 September 2026.Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales +7 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 18, 28 September 2026.This review outlines a pioneering strategy to inhibit Leishmania infantum trypanothione reductase by disrupting its dimer interface. From peptides to small‐molecule proteomimetics, multiple chemotypes achieved potent enzymatic inhibition and notable cellular antileishmanial activity, highlighting a new therapeutic paradigm.
María‐José Camarasa +3 more
wiley +1 more source
What Is Your Diagnosis? Blood Smear From a North American Beaver (Castor canadensis)
Veterinary Clinical Pathology, EarlyView.
Lilani Munasinghe +4 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 17, 14 September 2026.Evaluation of two libraries of peptoid‐based compounds for inhibitory activity against PfA‐M1 from Plasmodium falciparum, TcLAP from Trypanosoma cruzi, and LmLAP from Leishmania major reveals the crucial role of hydrophobic interactions in the inhibition process of these parasite metallo‐aminopeptidases.
Mirta Elisa Aguado +16 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, Volume 600, Issue 17, Page 2547-2563, September 2026.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies
Advanced Science, Volume 13, Issue 50, 7 September 2026.Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi +5 more
wiley +1 more source