Results 221 to 230 of about 41,700 (258)
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Molecular Pharmacology, 2001
The trypanocidal action of pentamidine is dependent on the rapid, selective accumulation of this drug by the parasite. We have investigated pentamidine transport by the bloodstream and procyclic life cycle stages of Trypanosoma brucei brucei.
H. D. de Koning
semanticscholar +1 more source
The trypanocidal action of pentamidine is dependent on the rapid, selective accumulation of this drug by the parasite. We have investigated pentamidine transport by the bloodstream and procyclic life cycle stages of Trypanosoma brucei brucei.
H. D. de Koning
semanticscholar +1 more source
The coatomer of Trypanosoma brucei
Molecular and Biochemical Parasitology, 2001Coatomer is a multisubunit complex involved in trafficking of vesicles between the endoplasmatic reticulum and the Golgi apparatus. From sequence homologies, all seven subunits, alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP, are encoded in the genome of Trypanosoma brucei.
Martina Bremser +5 more
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, 2014
The aim of the study was to evaluate the effect of treatment with DAFLON® 500 mg (DF) and/or diminazene aceturate (DZ) on hematological parameters in rats, infected with Trypanosoma brucei brucei.
P. I. Kobo +4 more
semanticscholar +1 more source
The aim of the study was to evaluate the effect of treatment with DAFLON® 500 mg (DF) and/or diminazene aceturate (DZ) on hematological parameters in rats, infected with Trypanosoma brucei brucei.
P. I. Kobo +4 more
semanticscholar +1 more source
Experimental Parasitology, 1992
Macrophages collected from BCG-infected mice or exposed in vitro to interferon-gamma plus lipopolysaccharide developed a cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei. This trypanostatic activity of activated macrophages was inhibited by addition of N-monomethyl-L-arginine, an inhibitor of the L-arginine-nitric oxide
Bernard Veyret +5 more
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Macrophages collected from BCG-infected mice or exposed in vitro to interferon-gamma plus lipopolysaccharide developed a cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei. This trypanostatic activity of activated macrophages was inhibited by addition of N-monomethyl-L-arginine, an inhibitor of the L-arginine-nitric oxide
Bernard Veyret +5 more
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Glycolysis in Trypanosoma brucei [PDF]
European Journal of Biochemistry, 1980 The possibility that the glycosomes present in the bloodstream form of Trypanosoma brucei [Opperdoes, F. R. and Borst, P. (1977) FEBS Lett. 80, 360–364] constitute a separate pool of glycolytic intermediates within the cell was investigated.In titrations of intact cells with digitonin, a differential activation of glycolytic enzymes was observed ...
Nico Visser, Fred R. Opperdoes
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Molecular Pharmacology, 1999
Adenosine influx by Trypanosoma brucei brucei P1 and P2 transporters was kinetically characterized. The P1 transporter displayed a higher affinity and capacity for adenosine (K(m) = 0.38 +/- 0.10 microM, V(max) = 2.8 +/- 0.4 pmol x 10(7) cells(-1) x s(-1)
H. D. de Koning, Simon M. Jarvis
semanticscholar +1 more source
Adenosine influx by Trypanosoma brucei brucei P1 and P2 transporters was kinetically characterized. The P1 transporter displayed a higher affinity and capacity for adenosine (K(m) = 0.38 +/- 0.10 microM, V(max) = 2.8 +/- 0.4 pmol x 10(7) cells(-1) x s(-1)
H. D. de Koning, Simon M. Jarvis
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Effect of putrescine on the respiration of Trypanosoma brucei brucei
Molecular and Biochemical Parasitology, 1986When bloodstream forms of Trypanosoma brucei brucei were exposed to exogenous putrescine for 24 h during in vitro culture, the rate of O2 consumption increased significantly in a concentration-related and time-dependent manner. Trypanosomes cultured with 100 microM DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine ...
Bruce F. Giffin +2 more
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The Ubiquitin-Ligase System in Trypanosoma Brucei Brucei
The American Journal of Tropical Medicine and Hygiene, 1993The question of whether the African trypanosome Trypanosoma brucei brucei utilizes a ubiquitin-ligase system to conjugate the 8,500-dalton protein ubiquitin to other proteins has not been investigated. Using 125I-labeled ubiquitin and gel electrophoresis (sodium dodecyl sulfate and acetic acid, urea, Triton X-100), we looked for the incorporation of ...
D.J. Lowrie +2 more
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European Journal of Biochemistry, 1996
African trypanosomes contain proteases that may be released into the bloodstream of their infected hosts. This paper describes a novel, combined isolation of a cysteine proteinase (called trypanopain-Tb) and a serine oligopeptidase (which we call ...
Linda Troeberg +5 more
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African trypanosomes contain proteases that may be released into the bloodstream of their infected hosts. This paper describes a novel, combined isolation of a cysteine proteinase (called trypanopain-Tb) and a serine oligopeptidase (which we call ...
Linda Troeberg +5 more
semanticscholar +1 more source
Characterisation of pentamidine-resistant Trypanosoma brucei brucei
Molecular and Biochemical Parasitology, 1995Following selection in vitro by exposure to increasing concentrations of the aromatic diamidine pentamidine, a Trypanosoma brucei brucei clone has been characterised in vivo and in vitro. The resistant clone, designated T.b. brucei S427/118/PR32.6, was found to be less virulent than the parental clone T.b.
Berger, Bradley J. +2 more
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