Results 161 to 170 of about 53,099 (190)

Immunological control of chronic "Trypanosoma brucei gambiense" in outbred rodents

Acta tropica, 1984
Recent human isolates of Trypanosoma brucei gambiense generally fail to become or remain patent in laboratory rodents. The purpose of this study was to determine if this was due to acquired immunity and if so which immunosuppressive method was the most efficient in raising parasitemia levels.
P, Diffley, J O, Scott
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Effects of Heparin Administration on Trypanosoma brucei gambiense Infection in Rats

Journal of Parasitology, 2005
We examined whether heparin administration influences in vivo trypanosome proliferation in infected rats. Administration of heparin every 8 hr via cardiac catheter inhibited growth of Trypanosoma brucei gambiense and prolonged survival of treated rats.
Kazuhiko, Nishimura, Kensuke, Shima, Masahiro, Asakura, Yoshihiro, Ohnishi, Shinji, Yamasaki   +4 more
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DIFLUOROMETHYLORNITHINE FOR ARSENO-RESISTANT TRYPANOSOMA BRUCEI GAMBIENSE SLEEPING SICKNESS

The Lancet, 1987
26 patients with arseno-resistant Trypanosoma brucei gambiense trypanosomiasis were treated with difluoromethylornithine (eflornithine), an inhibitor of ornithine decarboxylase, given intravenously, then orally. There was rapid disappearance of trypanosomes in the cerebrospinal fluid (CSF), gradual decrease of CSF lymphocytosis, and parallel ...
J, Pepin, F, Milord, C, Guern, P J, Schechter   +3 more
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Long term exposure of Trypanosoma brucei gambiense to pentamidine in vitro

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994
In order to study the sensitivity in vitro of Trypanosoma brucei gambiense to pentamidine, 5 x 10(4) parasites were exposed to 0, 0.1, 1.0, 2.0, 10, 100, 1000 and 10,000 micrograms/L of pentamidine isethionate for up to 10 d. The viability of parasites was determined each day by microscopy.
T W, Miézan, U, Bronner, F, Doua, P, Cattand, L, Rombo   +4 more
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Freeze‐Fracture Study of the Bloodstream Form of Trypanosoma brucei gambiense

The Journal of Protozoology, 1990
ABSTRACTThe ultrastructure of Trypanosoma brucei gambiense was investigated by the freeze‐fracture method. Three different regions of the continuous plasma membrane; cell body proper, flagellar pocket, and flagellum were compared in density and distribution of the intramembranous particles (IMP's).
H, Yoshikawa, J, Furuki, Y, Takahashi, H, Morioka, Y, Yoshida   +4 more
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Neurochemical and Activity Changes in Rats Infected with Trypanosoma brucei gambiense

The Journal of Parasitology, 1984
The brains of rats infected with Trypanosoma brucei gambiense were analyzed for their content of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA). In the caudate of infected rats, dopamine levels increased by 34% and 5-HIAA levels by 20%.
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DIFFERENTIAL EFFECTS OF INTERFERON-γ ON PRODUCTION OF TRYPANOSOME-DERIVED LYMPHOCYTE-TRIGGERING FACTOR BY TRYPANOSOMA BRUCEI GAMBIENSE AND TRYPANOSOMA BRUCEI BRUCEI

Journal of Parasitology, 2004
Trypanosome-derived lymphocyte-triggering factor (TLTF) produced by Trypanosoma brucei brucei stimulates production of interferon-gamma (IFN-gamma) by CD8+ T cells, and it is reported that, in turn, IFN-gamma stimulates proliferation of T. b. brucei. We studied the role of TLTF in trypanosome proliferation using the Wellcome strain (WS) of Trypanosoma ...
Kazuhiko, Nishimura, Kanako, Hamashita, Yasuyuki, Okamoto, Fumiya, Kawahara, Hideshi, Ihara, Shunji, Kozaki, Yoshihiro, Ohnishi, Shinji, Yamasaki   +7 more
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Mechanism of Lysis of Trypanosoma brucei gambiense by Human Serum

The Journal of Parasitology, 1994
Resistance to lysis by human serum (HS) is an important parameter used to distinguish Trypanosoma brucei brucei from both Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Neither the exact nature of the trypanolytic factor (TLF) nor the mechanism of action by which HS lyses susceptible trypanosomes is well understood.
Juan Carlos Ortiz-Ordóñez, John B. Sechelski, John R. Seed, Juan Carlos Ortiz-Ordonez   +3 more
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Gonadotropic axis and Trypanosoma brucei gambiense infection.

Annales de la Societe belge de medecine tropicale, 1989
A gonad endocrine survey on 46 Congolese patients (15 women and 31 men) with parasitologically confirmed trypanosomiasis found amenorrhoea in 60% of the women and impotence in 70% of the men. The basic gonad endocrine examination showed a decrease in oestradiol levels in about 65% of the women. Both amenorrhoea and low oestrogen levels were observed in
A, Boersma, F, Noireau, M, Hublart, F, Boutignon, J L, Lemesre, A, Racadot, P, Degand   +6 more
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Phenylalanine metabolism in Microtus montanus chronically infected with Trypanosoma brucei gambiense

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1982
1. Alterations in phenylalanine metabolism were observed in Microtus montanus infected with Trypanosoma brucei gambiense. 2. Reductions were found in the incorporation of phenylalanine into free amino acid pools and into proteins of the liver and other organs of infected animals. 3.
J R, Seed, J E, Hall, J, Sechelski
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