Results 171 to 180 of about 7,822 (201)

Phospholipase A₂fromTrypanosoma brucei gambienseandTrypanosoma brucei brucei: Inhibition by Organotins

Journal of Enzyme Inhibition, 2001
Activity and kinetics of phospholipase A2 (PLA2) from Trypanosoma brucei gambiense (Wellcome strain) and Trypanosoma brucei brucei (GUTat 3.1) were examined using two different fluorescent substrates. The activity in the supernatants of sonicated parasites was Ca2+-independent, strongly stimulated by Triton X-100 with optimum activity at 37 degrees C ...
M N, Shuaibu, H, Kanbara, T, Yanagi, D A, Ameh, J J, Bonire, A J, Nok   +5 more
openaire   +2 more sources

Mechanism of Trypanosoma brucei gambiense resistance to human serum

Nature, 2013
The African parasite Trypanosoma brucei gambiense accounts for 97% of human sleeping sickness cases. T. b. gambiense resists the specific human innate immunity acting against several other tsetse-fly-transmitted trypanosome species such as T. b. brucei, the causative agent of nagana disease in cattle.
Uzureau, Pierrick, Uzureau, Sophie, Lecordier, Laurence, Fontaine, Frederic, Tebabi, Patricia, Homble, Fabrice, Grelard, Axelle, Zhendre, Vanessa, Nolan, Derek P., Lins, Laurence, Crowet, Jean-Marc, Pays, Annette, Felu, Cecile, Poelvoorde, Philippe, Vanhollebeke, Benoit, Moestrup, Soren K., Lyngso, Jeppe, Pedersen, Jan Skov, Mottram, Jeremy C., Dufourc, Erick J., Perez-Morga, David, Pays, Etienne   +21 more
openaire   +4 more sources

DIFLUOROMETHYLORNITHINE FOR ARSENO-RESISTANT TRYPANOSOMA BRUCEI GAMBIENSE SLEEPING SICKNESS

Lancet, The, 1987
26 patients with arseno-resistant Trypanosoma brucei gambiense trypanosomiasis were treated with difluoromethylornithine (eflornithine), an inhibitor of ornithine decarboxylase, given intravenously, then orally. There was rapid disappearance of trypanosomes in the cerebrospinal fluid (CSF), gradual decrease of CSF lymphocytosis, and parallel ...
J, Pepin, F, Milord, C, Guern, P J, Schechter   +3 more
exaly   +3 more sources

Immunological control of chronic "Trypanosoma brucei gambiense" in outbred rodents

Acta tropica, 1984
Recent human isolates of Trypanosoma brucei gambiense generally fail to become or remain patent in laboratory rodents. The purpose of this study was to determine if this was due to acquired immunity and if so which immunosuppressive method was the most efficient in raising parasitemia levels.
P, Diffley, J O, Scott
openaire   +2 more sources

Epidemiological evidence for immunity following Trypanosoma brucei gambiense sleeping sickness

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1995
In order to investigate whether protective immunity appears after Trypanosoma brucei gambiense sleeping sickness, we undertook a retrospective cohort study of 3 remote villages in central Zaire (total population 1431), in which 38% of all adults had a past history of human African trypanosomiasis.
N, Khonde, J, Pépin, T, Niyonsenga, F, Milord, P, De Wals   +4 more
openaire   +2 more sources

Phenylalanine metabolism in Microtus montanus chronically infected with Trypanosoma brucei gambiense

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1982
1. Alterations in phenylalanine metabolism were observed in Microtus montanus infected with Trypanosoma brucei gambiense. 2. Reductions were found in the incorporation of phenylalanine into free amino acid pools and into proteins of the liver and other organs of infected animals. 3.
J R, Seed, J E, Hall, J, Sechelski
openaire   +2 more sources

Gonadotropic axis and Trypanosoma brucei gambiense infection.

Annales de la Societe belge de medecine tropicale, 1989
A gonad endocrine survey on 46 Congolese patients (15 women and 31 men) with parasitologically confirmed trypanosomiasis found amenorrhoea in 60% of the women and impotence in 70% of the men. The basic gonad endocrine examination showed a decrease in oestradiol levels in about 65% of the women. Both amenorrhoea and low oestrogen levels were observed in
A, Boersma, F, Noireau, M, Hublart, F, Boutignon, J L, Lemesre, A, Racadot, P, Degand   +6 more
openaire   +1 more source

The role of immunoglobulins in immunity to Trypanosoma brucei gambiense

International Journal for Parasitology, 1977
Abstract The effects of IgM and IgG antibody molecules were compared on a weight basis by both agglutination and in vitro protection tests. It was shown that IgM is a better agglutinating antibody and in the presence of complement is also a better neutralizing antibody.
openaire   +2 more sources

Further Biochemical Characterization of Chronic Trypanosoma Brucei Gambiense-Microtus Montanus Infection

The American Society of Tropical Medicine and Hygiene, 1987
Tyrosine aminotransferase (TAT), glutamic-pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), and alkaline phosphatase (ALP) were measured in the serum and livers of Microtus montanus infected with Trypanosoma brucei gambiense. Only liver TAT and serum ALP showed significant changes.
J R, Seed, J, Sechelski, J E, Hall
openaire   +2 more sources

Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection

Parasite Immunology, 2016
SummaryAfrican trypanosomosis is a debilitating parasitic disease occurring in large parts of sub‐Saharan Africa. Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing disease. Multiple experimental murine models for trypanosomosis have demonstrated inflammation‐dependent apoptosis of ...
Cnops, Jennifer, Kauffmann, Florence, De Trez, Carl, Baltz, Théo, Keirsse, Jiri, Radwanska, Magdalena, Muraille, Eric, Magez, Stefan   +7 more
openaire   +4 more sources