The role of immunoglobulins in immunity to Trypanosoma brucei gambiense
International Journal for Parasitology, 1977Abstract The effects of IgM and IgG antibody molecules were compared on a weight basis by both agglutination and in vitro protection tests. It was shown that IgM is a better agglutinating antibody and in the presence of complement is also a better neutralizing antibody.
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Characterization of recombinant Trypanosoma brucei gambiense Translationally Controlled Tumor Protein (rTbgTCTP) and its interaction with Glossina midgut bacteria [PDF]
Geraldine Bossard +2 more
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Freeze‐Fracture Study of the Bloodstream Form of Trypanosoma brucei gambiense
The Journal of Protozoology, 1990ABSTRACTThe ultrastructure of Trypanosoma brucei gambiense was investigated by the freeze‐fracture method. Three different regions of the continuous plasma membrane; cell body proper, flagellar pocket, and flagellum were compared in density and distribution of the intramembranous particles (IMP's).
H, Yoshikawa +4 more
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Effects of Heparin Administration on Trypanosoma brucei gambiense Infection in Rats
Journal of Parasitology, 2005We examined whether heparin administration influences in vivo trypanosome proliferation in infected rats. Administration of heparin every 8 hr via cardiac catheter inhibited growth of Trypanosoma brucei gambiense and prolonged survival of treated rats.
Kazuhiko, Nishimura +4 more
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Long term exposure of Trypanosoma brucei gambiense to pentamidine in vitro
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994In order to study the sensitivity in vitro of Trypanosoma brucei gambiense to pentamidine, 5 x 10(4) parasites were exposed to 0, 0.1, 1.0, 2.0, 10, 100, 1000 and 10,000 micrograms/L of pentamidine isethionate for up to 10 d. The viability of parasites was determined each day by microscopy.
T W, Miézan +4 more
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Neurochemical and Activity Changes in Rats Infected with Trypanosoma brucei gambiense
The Journal of Parasitology, 1984The brains of rats infected with Trypanosoma brucei gambiense were analyzed for their content of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA). In the caudate of infected rats, dopamine levels increased by 34% and 5-HIAA levels by 20%.
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Mechanism of Lysis of Trypanosoma brucei gambiense by Human Serum
The Journal of Parasitology, 1994Resistance to lysis by human serum (HS) is an important parameter used to distinguish Trypanosoma brucei brucei from both Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Neither the exact nature of the trypanolytic factor (TLF) nor the mechanism of action by which HS lyses susceptible trypanosomes is well understood.
Juan Carlos Ortiz-Ordóñez +3 more
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Trypanosome-derived lymphocyte-triggering factor (TLTF) produced by Trypanosoma brucei brucei stimulates production of interferon-gamma (IFN-gamma) by CD8+ T cells, and it is reported that, in turn, IFN-gamma stimulates proliferation of T. b. brucei. We studied the role of TLTF in trypanosome proliferation using the Wellcome strain (WS) of Trypanosoma ...
Kazuhiko, Nishimura +7 more
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Gonadotropic axis and Trypanosoma brucei gambiense infection.
Annales de la Societe belge de medecine tropicale, 1989A gonad endocrine survey on 46 Congolese patients (15 women and 31 men) with parasitologically confirmed trypanosomiasis found amenorrhoea in 60% of the women and impotence in 70% of the men. The basic gonad endocrine examination showed a decrease in oestradiol levels in about 65% of the women. Both amenorrhoea and low oestrogen levels were observed in
A, Boersma +6 more
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Tissue Alterations in Microtus montanus Chronically Infected with Trypanosoma brucei gambiense
The Journal of Parasitology, 1991Changes in liver, spleen, kidneys, heart, and brain are reported for Microtus montanus chronically infected with Trypanosoma brucei gambiense. An increase in body weight of infected animals was attributable to a significant increase in total mass of spleen, liver and kidney.
T O, Frommel, Y, Fujikura, J R, Seed
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