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African Trypanosomes: Trypanosoma brucei gambiense (Dutton 1902) and Trypanosoma brucei rhodesiense (Stephens and Fantham 1910)

1995
Trypanosoma brucei gambiense and T. b. rhodesiense, two subspecies of hemoflagellates, are responsible for a disease commonly referred to as African trypanosomiasis. Both of these organisms are transmitted by the bite of various species of the tsetse fly of the genus Glossina (see Chap. 38) and infect human populations throughout Equatorial Africa.
Dickson D. Despommier   +2 more
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Tissue Alterations in Microtus montanus Chronically Infected with Trypanosoma brucei gambiense

The Journal of Parasitology, 1991
Changes in liver, spleen, kidneys, heart, and brain are reported for Microtus montanus chronically infected with Trypanosoma brucei gambiense. An increase in body weight of infected animals was attributable to a significant increase in total mass of spleen, liver and kidney.
T O, Frommel, Y, Fujikura, J R, Seed
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A receptor-like flagellar pocket glycoprotein specific to Trypanosoma brucei gambiense

Molecular and Biochemical Parasitology, 2001
Trypanosoma brucei gambiense and T. b. rhodesiense are protozoan parasites causing sleeping sickness in humans due to their resistance to lysis by normal human serum (NHS). Based on the observation that the resistance gene of T. b. rhodesiense encodes a truncated form of the variant specific glycoprotein (VSG), we cloned a similar gene in T.
Berberof, M   +2 more
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Long term exposure of Trypanosoma brucei gambiense to pentamidine in vitro

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994
In order to study the sensitivity in vitro of Trypanosoma brucei gambiense to pentamidine, 5 x 10(4) parasites were exposed to 0, 0.1, 1.0, 2.0, 10, 100, 1000 and 10,000 micrograms/L of pentamidine isethionate for up to 10 d. The viability of parasites was determined each day by microscopy.
T W, Miézan   +4 more
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Effects of Heparin Administration on Trypanosoma brucei gambiense Infection in Rats

Journal of Parasitology, 2005
We examined whether heparin administration influences in vivo trypanosome proliferation in infected rats. Administration of heparin every 8 hr via cardiac catheter inhibited growth of Trypanosoma brucei gambiense and prolonged survival of treated rats.
Kazuhiko, Nishimura   +4 more
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Freeze‐Fracture Study of the Bloodstream Form of Trypanosoma brucei gambiense

The Journal of Protozoology, 1990
ABSTRACTThe ultrastructure of Trypanosoma brucei gambiense was investigated by the freeze‐fracture method. Three different regions of the continuous plasma membrane; cell body proper, flagellar pocket, and flagellum were compared in density and distribution of the intramembranous particles (IMP's).
H, Yoshikawa   +4 more
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Neurochemical and Activity Changes in Rats Infected with Trypanosoma brucei gambiense

The Journal of Parasitology, 1984
The brains of rats infected with Trypanosoma brucei gambiense were analyzed for their content of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA). In the caudate of infected rats, dopamine levels increased by 34% and 5-HIAA levels by 20%.
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[Acute Trypanosoma brucei gambiense meningoencephalitis detected by papillary edema].

Bulletin de la Societe de pathologie exotique (1990), 1996
A 26 year old woman, living in Brazzaville, was referred by her ophthalmologist about papillo-oedema. Neurological examination showed frontal syndrome and papillo-oedema without another sign of intracranial hypertension. Electroencephalogram revealed bilateral delta waves and bifrontal points. Significant inflammatory syndrome was noted.
J M, Zola   +3 more
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Trypanosoma brucei gambiense

1991
R. Ringelmann, Beate Heym
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