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Neurochemical and Activity Changes in Rats Infected with Trypanosoma brucei gambiense
The Journal of Parasitology, 1984The brains of rats infected with Trypanosoma brucei gambiense were analyzed for their content of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA). In the caudate of infected rats, dopamine levels increased by 34% and 5-HIAA levels by 20%.
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The substitution of procyclic for bloodstream form Trypanosoma brucei gambiense in isoenzyme studies
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1990Examination of 10 enzymes from 8 stocks of Trypanosoma brucei showed that procyclic forms could be substituted for bloodstream forms in isoenzyme studies. T. b. gambiense procyclic forms cultured in vitro offer a better source of material for genetic investigations because this species is usually of low infectivity and virulence to laboratory rodents ...
S.M. Lanham +3 more
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Phenylalanine metabolism in Microtus montanus chronically infected with Trypanosoma brucei gambiense
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19821. Alterations in phenylalanine metabolism were observed in Microtus montanus infected with Trypanosoma brucei gambiense. 2. Reductions were found in the incorporation of phenylalanine into free amino acid pools and into proteins of the liver and other organs of infected animals. 3.
James Edwin Hall +2 more
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The Lancet, 1992
The usual first-line treatment for Trypanosoma brucei gambiense sleeping sickness is melarsoprol, but when that fails the outlook has hitherto been grim. The polyamine synthesis inhibitor eflornithine (difluoromethylornithine, DFMO) has emerged as an alternative therapy. 207 patients with late-stage T b gambiense sleeping sickness were treated in rural
F Milord +6 more
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The usual first-line treatment for Trypanosoma brucei gambiense sleeping sickness is melarsoprol, but when that fails the outlook has hitherto been grim. The polyamine synthesis inhibitor eflornithine (difluoromethylornithine, DFMO) has emerged as an alternative therapy. 207 patients with late-stage T b gambiense sleeping sickness were treated in rural
F Milord +6 more
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Tissue Alterations in Microtus montanus Chronically Infected with Trypanosoma brucei gambiense
The Journal of Parasitology, 1991Changes in liver, spleen, kidneys, heart, and brain are reported for Microtus montanus chronically infected with Trypanosoma brucei gambiense. An increase in body weight of infected animals was attributable to a significant increase in total mass of spleen, liver and kidney.
Yoshihisa Fujikura +2 more
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A procedure for isolating and freezing metacyclic Trypanosoma brucei gambiense forms in the field
Acta Tropica, 2004An adaptation of a modified procedure using anion-exchange centrifugation was evaluated to isolate and freeze in field conditions a high number of bloodstream forms of Trypanosoma brucei gambiense for direct in vitro culture. Pellets of trypanosomes were obtained from 62 patients in Central Africa.
Philippe Truc +3 more
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A receptor-like flagellar pocket glycoprotein specific to Trypanosoma brucei gambiense
Molecular and Biochemical Parasitology, 2001Trypanosoma brucei gambiense and T. b. rhodesiense are protozoan parasites causing sleeping sickness in humans due to their resistance to lysis by normal human serum (NHS). Based on the observation that the resistance gene of T. b. rhodesiense encodes a truncated form of the variant specific glycoprotein (VSG), we cloned a similar gene in T.
Berberof, M +2 more
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Epidemiological evidence for immunity following Trypanosoma brucei gambiense sleeping sickness
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1995In order to investigate whether protective immunity appears after Trypanosoma brucei gambiense sleeping sickness, we undertook a retrospective cohort study of 3 remote villages in central Zaire (total population 1431), in which 38% of all adults had a past history of human African trypanosomiasis.
Jacques Pépin +4 more
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Quantification of tryptophan catabolites from Trypanosoma brucei gambiense in vitro
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1981Abstract 1. 1. Catabolites of tryptophan formed by Trypanosoma brucei gambiense in vitro were measured by gas liquid chromatography and radiotracer techniques. 2. 2. Indole-3-pyruvic acid was detected in incubates along with the previously detected catabolites indole-3-lactic acid, indole-3-acetic acid and indole-3-ethanol (tryptophol). 3.
John Richard Seed +2 more
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Infection of tsetse with Trypanosoma brucei rhodesiense and T. b. gambiense
1997Trypanosoma brucei rhodesiense and T. b. gambiense are salivarian trypanosomes (subgenus Trypanozoon) which are major pathogens of humans causing, respectively, the acute (Rhodesian) and chronic (Gambian) forms of sleeping sickness in Africa. Both trypanosome species are transmitted during feeding via the salivary glands of tsetse flies, both sexes of ...
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