Results 181 to 190 of about 7,746 (218)
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Mitogenicity of autolysates ofTrypanosoma congolense
Experientia, 1978Autolysates of Trypanosoma congolense, in subcytotoxic amounts, were found to be highly mitogenic in vitro for the spleen cells of normal mice. Significant amounts of [3H]-thymidine were also incorporated by the responding spleen cells of nu/nu (athymic) mice. In contrast, the spleen cells of cyclophosphamide-treated mice were unresponsive.
R K, Assoku, I R, Tizard
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Congopain from Trypanosoma congolense: Drug Target and Vaccine Candidate [PDF]
Trypanosomes are the etiological agents of human sleeping sickness and livestock trypanosomosis (nagana), which are major diseases in Africa. Their cysteine proteases (CPs), which are members of the papain family, are expressed during the infective stages of the parasites' life cycle.
Lalmanach, Gilles +6 more
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A modified AFLP for Trypanosoma congolense isolate characterisation
Journal of Biotechnology, 2006The amplified fragment length polymorphism (AFLP) technique is a reliable and powerful DNA fingerprint tool for genetic characterisation and analysis. In this paper, we described a modified AFLP with high resolution for Trypanosoma congolense using one enzyme and agarose or Elchrom gel electrophoresis.
Masumu, J. +4 more
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Genetic resistance to Trypanosoma congolense infections in mice
Infection and Immunity, 1980The mechanisms of genetic resistance or "trypanotolerance" to infection with Trypanosoma congolense were investigated in two strains of mice. One strain C57BL, is outstandingly resistant to most stabilates of T. congolense and can survive for over 80 days, whereas CFLP, in common with most other strains, generally succumbs in less than 20 days ...
D D, Whitelaw +4 more
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Two enzymically distinct stocks of Trypanosoma congolense
Research in Veterinary Science, 1986Two stocks of Trypanosoma congolense, isolated from a sheep and a goat on the Kenyan coast, were found to be distinctly different from 112 other stocks of the same species after comparing, by isoenzyme electrophoresis, trypanosomes originating from various parts of Africa.
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Studies on the carbohydrate metabolism of Trypanosoma congolense
Experimental Parasitology, 1954Abstract 1. 1. The rate of oxygen consumption of T. congolense is nearly as high as that of the trypanosomes of the evansi-brucei groups, but its rate of glucose consumption is lower. 2. 2. The R.Q. is high. 3. 3. The main metabolic end products, accounting nearly quantitatively for the degraded glucose, are acetic acid, pyruvic acid,
M, AGOSIN, T, VON BRAND
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A calcium dependent endoribonuclease from Trypanosoma congolense cytoplasm
Molecular and Biochemical Parasitology, 1984A major endoribonuclease whose activity depends on the presence of calcium ions was isolated from the cytoplasm of Trypanosoma congolense. Like the Ca2+-dependent endoribonuclease of T. brucei cytoplasm, this enzyme degraded poly(A) preferentially but also degraded to a lesser extent poly(U), tRNA and rRNA to give 5'-phosphoribosyl oligonucleotides ...
G O, Gbenle, E O, Akinrimisi
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Alterations in drug transport in resistant Trypanosoma congolense
Acta Tropica, 1993The transport of isometamidium chloride (Samorin) in Trypanosoma congolense which were either sensitive or resistant to this widely used trypanocide was studied in vitro. Significantly lower amounts of drug were accumulated over time by resistant than by sensitive trypanosomes.
I A, Sutherland, P H, Holmes
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Demonstration of erythrophagocytosis in Trypanosoma congolense-infected goats
Veterinary Parasitology, 2001Anaemia is the most prominent clinical sign of trypanosomosis in domestic animals but little is known about its pathogenesis. This work investigated erythrophagocytosis as the possible cause of anaemia. Pathogenic Trypanosoma congolense (IL3000) was intravenously inoculated into six goats at 3x10(6) trypanosomes per goat.
W H, Witola, C E, Lovelace
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