Results 91 to 100 of about 144,739 (262)

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

A Brief View of the Surface Membrane Proteins from Trypanosoma cruzi

Journal of Parasitology Research, 2017
Trypanosoma cruzi is the causal agent of Chagas' disease which affects millions of people around the world mostly in Central and South America. T. cruzi expresses a wide variety of proteins on its surface membrane which has an important role in the ...
Á. Pech-Canul, V. Monteón, R. Solis-Oviedo   +2 more
semanticscholar   +1 more source

Genome-wide analysis of 30 -untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes [PDF]

, 2013
In eukaryotic cells, a group of messenger ribonucleic acids (mRNAs) encoding functionally interrelated proteins together with the trans-acting factors that coordinately modulate their expression is termed a post-transcriptional regulon, due to their ...
Agüero, Fernan Gonzalo, Carmona, Santiago Javier, de Gaudenzi, Javier Gerardo, Frasch, Alberto Carlos C.   +3 more
core   +3 more sources

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Molecular characterization of Trypanosoma cruzi Mexican strains and their behavior in the mouse experimental model

Revista da Sociedade Brasileira de Medicina Tropical, 2011
INTRODUCTION: For a long time, the importance of Chagas disease in Mexico, where many regarded it as an exotic malady, was questioned. Considering the great genetic diversity among isolates of Trypanosoma cruzi, the importance of this biological ...
César Gómez-Hernández, Karine Rezende-Oliveira, Gabriel Antônio Nogueira Nascentes, Lara Rocha Batista, Henrique Borges Kappel, José Alejandro Martinez-Ibarra, Francisco Trujillo Contreras, Eliane Lages-Silva, Luis Eduardo Ramírez   +8 more
doaj   +1 more source

CRISPR/Cas9-mediated endogenous C-terminal Tagging of Trypanosoma cruzi Genes Reveals the Acidocalcisome Localization of the Inositol 1,4,5-Trisphosphate Receptor*

Journal of Biological Chemistry, 2016
Methods for genetic manipulation of Trypanosoma cruzi, the etiologic agent of Chagas disease, have been highly inefficient, and no endogenous tagging of genes has been reported to date.
N. Lander, M. Chiurillo, Melissa Storey, A. Vercesi, R. Docampo   +4 more
semanticscholar   +1 more source

The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa

The FEBS Journal, EarlyView.
Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte, Mariana N. R. Trujilho, Karolaine S. S. M. Valdivia, Aline F. Araujo, Laura M. C. de Lorena, Vinicius H. de Oliveira, Beatriz V. Pereira, Emilly R. Leme, Wagner A. S. Júdice, Maurício F. M. Machado   +9 more
wiley   +1 more source

Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system. [PDF]

, 2021
Leticia Laura Niborski, Mariana Potenza, Renato G.S. Chirivi, Leandro Simonetti, Micaela S. Ossowski, Vanina Grippo, María May, Daniela I. Staquicini, Adriana Parodi‐Talice, Carlos Robello, Marcelo A. Comini, G. Alonso, Jos Raats, Karina A. Gómez   +13 more
openalex   +1 more source

Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model [PDF]

, 2016
Chronic obesity and Chagas disease (caused by the protozoan Trypanosoma cruzi) represent serious public health concerns. The interrelation between parasite infection, adipose tissue, immune system and metabolism in an obesogenic context, has not been ...
Andrada, Marta Cecilia, Aoki, Maria del Pilar, Cabalén, María Eugenia, Cabral, Maria Fernanda, Cano, Roxana Carolina, Gea, Susana, Onofrio, Luisina Inés, Ponce, Nicolás Eric, Sanmarco, Liliana Maria   +8 more
core   +4 more sources

Artificial intelligence‐powered microscopy: Transforming the landscape of parasitology

Journal of Microscopy, EarlyView.
Abstract Microscopy and image analysis play a vital role in parasitology research; they are critical for identifying parasitic organisms and elucidating their complex life cycles. Despite major advancements in imaging and analysis, several challenges remain. These include the integration of interdisciplinary data; information derived from various model
Mariana De Niz, Sara Silva Pereira, David Kirchenbuechler, Leandro Lemgruber, Constadina Arvanitis   +4 more
wiley   +1 more source