Results 91 to 100 of about 133,982 (304)

CRISPR/Cas9-mediated endogenous C-terminal Tagging of Trypanosoma cruzi Genes Reveals the Acidocalcisome Localization of the Inositol 1,4,5-Trisphosphate Receptor*

Journal of Biological Chemistry, 2016
Methods for genetic manipulation of Trypanosoma cruzi, the etiologic agent of Chagas disease, have been highly inefficient, and no endogenous tagging of genes has been reported to date.
N. Lander, M. Chiurillo, Melissa Storey, A. Vercesi, R. Docampo   +4 more
semanticscholar   +1 more source

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, EarlyView.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Prevalence of antibodies against Trypanosoma cruzi in pregnant women in endemic areas of the department of Boyacá, Colombia

Iatreia, 2017
Objective: To determine the prevalence of antibodies against Trypanosoma cruzi in pregnant women in endemic areas of Boyacá, Colombia, in 2012 and 2013.
Suescún-Carrero, Sandra Helena, García-Artunduaga, Claudia, Valdivieso-Bohórquez, Silvia   +2 more
doaj   +1 more source

Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis [PDF]

, 2013
BACKGROUND: Chagas disease is caused by the parasite Trypanosoma cruzi and is endemic in much of Latin America. With increased globalisation and immigration, it is a risk in any country, partly through congenital transmission. The frequency of congenital
Buekens, Pierre, Carlier, Yves, Howard, Elizabeth J., Sosa-estani, Sergio Alejandro, Xiong, Xu   +4 more
core   +1 more source

A Brief View of the Surface Membrane Proteins from Trypanosoma cruzi

Journal of Parasitology Research, 2017
Trypanosoma cruzi is the causal agent of Chagas' disease which affects millions of people around the world mostly in Central and South America. T. cruzi expresses a wide variety of proteins on its surface membrane which has an important role in the ...
Á. Pech-Canul, V. Monteón, R. Solis-Oviedo   +2 more
semanticscholar   +1 more source

Increased CD8dim and Decreased CD8bright T Cells as Immunological Signature for Multibacilary Leprosy Patients

Immunology, EarlyView.
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, manifests in a spectrum of clinical forms and severity. This study investigated the percentage of CD8+ T cells and their subpopulations (CD8bright and CD8dim T cells) in leprosy patients stratified by clinical forms, bacterial load, and age.
Yuri Scheidegger de Castro, Letícia Silva Nascimento, Juliana Azevedo da Silva, Rebeka da Conceição Souza, Gabriel Nogueira Araújo, Sandra Chalhub de Oliveira, Edilbert Pellegrini Nahn Junior, Alba Lucínia Peixoto‐Rangel   +7 more
wiley   +1 more source

Virtual Screening Based on QSAR and Molecular Docking of Possible Inhibitors Targeting Chagas CYP51

Journal of Chemistry, 2021
Chagas is a neglected tropical disease caused by the parasite Trypanosoma cruzi with no effective treatment in all its forms. There is a need to find more effective therapeutic alternatives with reduced toxicity.
J. Cotuá, H. LLinás, S. Cotes
doaj   +1 more source

Epidemiological modeling of Trypanosoma cruzi: Low stercorarian transmission and failure of host adaptive immunity explain the frequency of mixed infections in humans [PDF]

, 2017
People living in areas with active vector-borne transmission of Chagas disease have multiple contacts with its causative agent, Trypanosoma cruzi. Reinfections by T.
Aparicio, Juan Pablo, Diosque, Patricio, Gourbière, Sébastien, Ragone, Paula Gabriela, Tomasini, Nicolás   +4 more
core   +3 more sources

Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors targeting the α-class enzyme from the protozoan pathogen Trypanosoma cruzi, responsible of Chagas disease, were recently reported.
Alane Beatriz Vermelho, Verônica da Silva Cardoso, Eduardo Ricci Júnior, E. D. dos Santos, C. Supuran   +4 more
semanticscholar   +1 more source