Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal. [PDF]
, 2015 An improved understanding of how a parasite species exploits its genetic repertoire to colonize novel hosts and environmental niches is crucial to establish the epidemiological risk associated with emergent pathogenic genotypes.
Bustamante, Marinely +8 more
core +4 more sources
The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection [PDF]
, 2016 The protozoan parasite Trypanosoma cruzi circulates in the blood upon infection and invades various cells. Parasites intensively multiply during the acute phase of infection and persist lifelong at low levels in tissues and blood during the chronic phase.
Almeida +48 more
core +2 more sources
Parasites & Vectors, 2018 Trypanosoma cruzi uses several strategies to survive in different hosts. A key step in the life-cycle of this parasite is metacyclogenesis, which involves various morphological, biochemical, and genetic changes that induce the differentiation of non ...
C. S. Gonçalves +4 more
semanticscholar +1 more source
Infectivity of amastigotes of Trypanosoma cruzi [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 1986 The infectivity amastigotes of Trypanosoma cruzi, isolated from the supernatant of the J774G8 macrophage-like cell line infected with trypomastigotes to normal macrophages in vitro was tested. After a period of 1 h of T. cruzi-macrophage interaction about 2% of the mouse peritoneal macrophages had ingested amastigotes.
Carvalho, Tecia Ulisses de +1 more
openaire +5 more sources
Protective immunity against Trypanosoma cruzi [PDF]
, 2009 Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed.
Basombrío, Miguel Ángel Manuel +2 more
core +1 more source
Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure
bioRxiv, 2017 The ability of the Chagas disease agent Trypanosoma cruzi to resist extended in vivo exposure to highly effective trypanocidal compounds prompted us to explore the potential for dormancy and its contribution to failed drug treatments in this infection ...
Fernando Sanchez-Valdez +4 more
semanticscholar +1 more source
Biology of Trypanosoma cruzi: An update [PDF]
Infectio, 2012 AbstractChagas disease, an illness caused by the protozoan Trypanosoma cruzi, is clinically and epidemiologically important in Latin America, and particularly in Brazil. This article presents the main biological characteristics of Trypanosoma cruzi, emphasizing ultrastructural, morphological, evolutionary, transcriptomic, and proteomic aspects.
Martins, André Vianna +9 more
openaire +2 more sources
Treatment with a new peroxisome proliferator-activated receptor gamma agonist, pyridinecarboxylic acid derivative, increases angiogenesis and reduces inflammatory mediators in the heart of Trypanosoma cruzi-infected mice [PDF]
, 2017 Trypanosoma cruzi infection induces an intense inflammatory response in diverse host tissues. The immune response and the microvascular abnormalities associated with infection are crucial aspects in the generation of heart damage in Chagas disease.
Carta, Davide +9 more
core +4 more sources
TcI isolates of Trypanosoma cruzi exploit the antioxidant network for enhanced intracellular survival in macrophages and virulence in mice [PDF]
, 2016 Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause of human disease. In our study, the TcI strains Colombiana (COL),
Basombrío, Miguel Ángel Manuel +8 more
core +2 more sources
PLoS ONE, 2018 The occurrence of Trypanosoma spp. in wild carnivore populations has been intensively investigated during the last decades. However, the impact of these parasites on the health of free-living infected animals has been largely neglected.
F. M. Santos +13 more
semanticscholar +1 more source