Results 81 to 90 of about 143,738 (310)

Calculation of the ELISA’s cut-off based on the change-point analysis method for detection of Trypanosoma cruzi infection in Bolivian dogs in the absence of controls

Memórias do Instituto Oswaldo Cruz, 2016
In ELISAs, sera of individuals infected by Trypanosoma cruzi show absorbance values above a cut-off value. The cut-off is generally computed by means of formulas that need absorbance readings of negative (and sometimes positive) controls, which are ...
F. Lardeux, Gino Torrico, C. Aliaga
semanticscholar   +1 more source

Construction of three new Gateway® expression plasmids for Trypanosoma cruzi [PDF]

, 2014
We present here three expression plasmids for Trypanosoma cruzi adapted to the Gateway® recombination cloning system. Two of these plasmids were designed to express trypanosomal proteins fused to a double tag for tandem affinity purification (TAPtag ...
Alonso, Victoria Lucia, Cribb, Pamela, Ritagliati, Carla, Serra, Esteban Carlos   +3 more
core   +4 more sources

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Identification of seropositive cases of Chagas disease in pregnant women in a non-endemic risk area of the state of Mexico: The importance of screening prenatal

Parasite Epidemiology and Control
Objective: Our study aimed to identify seropositive cases of Trypanosoma cruzi in pregnant women from the northeastern region of the State of Mexico and underscore the importance of screening for this disease in prenatal care.
Saúl González-Guzmán, José A. Crescencio-Trujillo, Carla I. Arroyo-Anduiza, María Guadalupe Córdova-Espinoza, Roberto Alvarado-Velázquez, Vladimir Paredes-Cervantes   +5 more
doaj   +1 more source

Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM) [PDF]

, 2015
Background Trypanosoma cruzi, causative agent of Chagas disease, displays high intraspecific genetic diversity: six genetic lineages or discrete typing units (DTUs) are currently recognized, termed TcI through TcVI.
Bhattacharyya, T., Burleigh, B.A., Costales, J.A., Garcia-Perez, J., Kotton, C.N., Llewellyn, M.S., Messenger, L.A., Zurita-Leal, A.C.   +7 more
core   +2 more sources

Bioactivity Profiles of Progressively Ring‐Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto‐Piperazines as Antitrypanosome Agents

ChemBioChem, EarlyView.
All‐cis‐fluorinated cyclohexyl motifs with progressively increasing levels of fluorine are introduced into the WKYMVm peptide and a class of keto‐piperazine derivatives and assayed against the FPR2 receptor or the parasite Trypanosoma brucei, respectively.
Mengfan He, Christina M. Thomson, Dawn Thompson, Vytautus Kuodis, Terry K. Smith, Sergio Dall’Angelo, David O’Hagan   +6 more
wiley   +1 more source

Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi

mBio, 2017
Trypanosoma cruzi is the agent of Chagas disease, and the finding that this parasite possesses a mitochondrial calcium uniporter (TcMCU) with characteristics similar to that of mammalian mitochondria was fundamental for the discovery of the molecular ...
M. Chiurillo, N. Lander, Mayara S Bertolini, Melissa Storey, A. Vercesi, R. Docampo   +5 more
semanticscholar   +1 more source

The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America [PDF]

, 2018
It is estimated that between 8000 and 15 000 Trypanosoma cruzi infected babies are born every year to infected mothers in Chagas disease endemic countries. Currently, poor access to and performance of the current diagnostic algorithm, based on microscopy
Cruz, Israel, Katz, Zachary, Ndung'u, Joseph Mathu, Picado, Albert, Redard Jacot, Maël, Schijman, Alejandro Gabriel, Sosa-Estani, Sergio Alejandro, Torrico, Faustino   +7 more
core   +1 more source

FIGO good practice recommendations on preconception care: A strategy to prevent preterm birth

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Preterm birth (PTB) remains one of the leading causes of neonatal mortality and long‐term morbidity worldwide, with minimal progress being made in reducing its incidence, particularly in low‐resource settings. Preconception care is recognized as an effective strategy for PTB prevention; however, the fact that more than half of pregnancies ...
Leticia Irma Ojeda, Catalina M. Valencia, Natalia Cardozo Buitrago, Dilly Anumba, Wondimu Gudu, Ana Bianchi, Bo Jacobsson, on behalf of the FIGO Committee for Preterm Birth, Catalina M. Valencia González, Dilly Anumba, Wondimu Gudu, Bo Jacobsson, Nancy Sierra Lozada, Leticia Ojeda, Madhuri Patel, Andrew Shennan, Rodrigo Rigoni, Priya Soma‐Pillay, Sherri Ann Suplido, Ana Daneva, Sikolia Wanyonyi, Haim Abenhaim   +21 more
wiley   +1 more source

Widespread Trypanosoma cruzi infection in government working dogs along the Texas-Mexico border: Discordant serology, parasite genotyping and associated vectors

PLoS Neglected Tropical Diseases, 2017
Background Chagas disease, caused by the vector-borne protozoan Trypanosoma cruzi, is increasingly recognized in the southern U.S. Government-owned working dogs along the Texas-Mexico border could be at heightened risk due to prolonged exposure outdoors ...
Alyssa C. Meyers, Marvin Meinders, S. Hamer   +2 more
semanticscholar   +1 more source