Modulation of the Immune Response by Nematode Secreted Acetylcholinesterase Revealed by Heterologous Expression in Trypanosoma musculi. [PDF]
PLoS Pathogens, 2016 Nematode parasites secrete molecules which regulate the mammalian immune system, but their genetic intractability is a major impediment to identifying and characterising the biological effects of these molecules.
Rachel Vaux +6 more
doaj +2 more sources
Infection with Trypanosoma lewisi or Trypanosoma musculi may promote the spread of Toxoplasma gondii. [PDF]
Parasitology, 2021 Abstract Toxoplasma gondii can infect almost all warm-blooded vertebrates with pathogensis being largely influenced by the host immune status. As important epidemiological hosts, rodents are globally distributed and are also commonly found infected with haemoflagellates, such as those in the ...
Gao JM +6 more
europepmc +4 more sources
Kinetoplast DNA structure, RNA editing patterns and small respiratory Complex I in Trypanosoma musculi [PDF]
Communications BiologyKinetoplast (k) DNA, a specialized form of mitochondrial DNA in trypanosomes, is composed of catenated maxicircles and minicircles, and is essential for the survival of these parasitic protists.
Ju-Feng Wang +5 more
doaj +2 more sources
Trypanosoma musculi infection in B-cell-deficient mice. [PDF]
Infect Immun, 1984 The course of infection with Trypanosoma musculi was assessed in mice deprived of B-lymphocytes by administration, from birth, of rabbit antiserum to mouse immunoglobulin M (IgM). Initial control of parasitemia leading to the first crisis and establishment of the plateau phase was unaffected by lack of B-lymphocyte function, although multiplicative ...
Vargas FD, Viens P, Kongshavn PA.
europepmc +4 more sources
Macrophage function during Trypanosoma musculi infection in mice. [PDF]
Infect Immun, 1981 Quantitative and functional changes in peritoneal macrophages from mice infected with Trypanosoma musculi were investigated. Increase in the number and size and in the protein content of peritoneal macrophages and the presence of parasites in the peritoneal activity were observed during the course of parasitemia. Induced releases of H2O2 by macrophages
Vincendeau P, Caristan A, Pautrizel R.
europepmc +4 more sources
Lipopolysaccharide hyperreactivity of animals infected with Trypanosoma lewisi or Trypanosoma musculi. [PDF]
Infect Immun, 1984 Rats and mice infected with Trypanosoma lewisi and Trypanosoma musculi, respectively, showed hyperreactivity to lipopolysaccharide (LPS) from gram-negative bacteria. Fatal shock could be precipitated with a dose of LPS 100 to 1,000 times less in infected compared with noninfected animals.
Ferrante A +3 more
europepmc +3 more sources
Natural killer activity in mice infected with Trypanosoma musculi. [PDF]
Infect Immun, 1983 Trypanosoma musculi infection affected natural killer (NK) activity in mice. In the spleen, an increase of two to three times normal was displayed on days 2 to 4 after inoculation of parasites, followed by rapid decline to a subnormal level of activity that persisted for more than 3 weeks and included the phase of rapid parasite elimination.
Albright JW, Huang KY, Albright JF.
europepmc +4 more sources
Histopathological and immunocytochemical studies of Trypanosoma musculi infection of mice. [PDF]
Infect Immun, 1981 Mice infected with Trypanosoma musculi developed hyperplasia of the spleen, lymph nodes, and liver; in contrast, their thymuses displayed transient involution. All organs returned to normal in a month or less. There was modest anemia, lasting until the parasites were cleared from the bloodstream, followed by a rapid influx of erythrocytes into the ...
Hirokawa K +3 more
europepmc +4 more sources
Further characterization of the curative antibodies in Trypanosoma musculi infection. [PDF]
Infect Immun, 1988 The ability of immune plasma (IP) taken from different donor strains of mice to cure Trypanosoma musculi infection in various recipient mouse strains, when given during the plateau phase of infection, was examined. C57BL/6, B10.A/SgSn, B10.D2/oSn, B10.D2/nSn, DBA/2, and BALB/c strains could be cured of parasitemia (giving 0.4 to 0.8 ml of IP per mouse),
Wechsler DS, Kongshavn PA.
europepmc +3 more sources
Chronic infection with Trypanosoma musculi in congenitally athymic nude mice. [PDF]
Infect Immun, 1977 Trypanosoma musculi produces a chronic infection with a consistently elevated parasitemia in nude mice. Thymic reconstitution of nude mice restores immunity to the infection.
Rank RG, Roberts DW, Weidanz WP.
europepmc +4 more sources