Results 61 to 70 of about 9,059 (176)

Ovothiol and trypanothione as antioxidants in trypanosomatids

, 2001
The relative amounts of ovothiol A (N1-methyl-4-mercaptohistidine) and trypanothione [N1,N8-bis(glutathionyl)spermidine] have been determined in all life cycle stages of representative trypanosomatids (Leishmania spp, Crithidia fasciculata, Trypanosoma ...
Ariyanayagam, Mark R., Fairlamb, Alan H.; id_orcid   +1 more
core   +1 more source

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Organometallic derivatization of existing drugs is a common strategy to look for new drug candidates. This work describes the derivatization of the benzimidazole anthelmintic scaffold, from the synthesis of the organometallic derivatives to the evaluation of their biological properties. It highlights a broad range of antiparasitic activities and leaves
Corentin Ludwig, Aya C. Taki, Joseph J. Byrne, Pierre Mesdom, Olivier Blacque, Cécile Häberli, Trix Zumkehr, Gonzalo Scalese, Leticia Pérez‐Díaz, Dinorah Gambino, Britta Lundström‐Stadelmann, Jennifer Keiser, Robin B. Gasser, Kevin Cariou, Gilles Gasser   +14 more
wiley   +1 more source

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

Common Structural Patterns in the Maxicircle Divergent Region of Trypanosomatidae

Pathogens, 2020
Maxicircles of all kinetoplastid flagellates are functional analogs of mitochondrial genome of other eukaryotes. They consist of two distinct parts, called the coding region and the divergent region (DR). The DR is composed of highly repetitive sequences
Evgeny S. Gerasimov, Ksenia A. Zamyatnina, Nadezda S. Matveeva, Yulia A. Rudenskaya, Natalya Kraeva, Alexander A. Kolesnikov, Vyacheslav Yurchenko   +6 more
doaj   +1 more source

Biosynthesis of vitamins and cofactors in bacterium-harbouring trypanosomatids depends on the symbiotic association as revealed by genomic analyses. [PDF]

PLoS ONE, 2013
Some non-pathogenic trypanosomatids maintain a mutualistic relationship with a betaproteobacterium of the Alcaligenaceae family. Intensive nutritional exchanges have been reported between the two partners, indicating that these protozoa are excellent ...
Cecilia C Klein, João M P Alves, Myrna G Serrano, Gregory A Buck, Ana Tereza R Vasconcelos, Marie-France Sagot, Marta M G Teixeira, Erney P Camargo, Maria Cristina M Motta   +8 more
doaj   +1 more source

Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto, Kelly Lopes Figueira, Raquel Azevedo, Ketlym da Conceição, Ludmila de Ferreira de Almeida Fiuza, Luan dos Santos Vianna, Thiago Apolinário de Moraes, Wagner Alves de Souza Júdice, Maria de Nazaré Correia Soeiro, Jones Limberger   +9 more
wiley   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source

Genome sequencing project has begun on two plant trypanosomatids (Phytomonas) [PDF]

, 2010
Some trypanosomatids are responsible for wilt in tropical crops, such as hartrot disease in the coconut palm. They have a major economic impact in Latin America and the Caribbean.
Poulain, Julie, Jaillon, Olivier, Da Silva, Corinne, Aury, Jean-Marc, Noël, Benjamin, Wincker, Patrick, Dollet, Michel, Fabre, Sandrine, Couloux, Arnaud, Artiguenave, Françoise   +9 more
core  

Differential diagnosis of the honey bee trypanosomatids Crithidia mellificae and Lotmaria passim [PDF]

, 2015
Trypanosomatids infecting honey bees have been poorly studied with molecular methods until recently. After the description of Crithidia mellificae (Langridge and McGhee, 1967) it took about forty years until molecular data for honey bee trypanosomatids ...
Descamps, Tine, Evans, Jay D, de Graaf, Dirk C., Bartolomé, Carolina, Martin-Hernandez, Raquel, Ravoet, Jorgen, Yanez Amayo, Victor Orlando, Evans, Jay D., de Graaf, Dirk C, Schwarz, Ryan S, Tozkar, Cansu Ozge, Neumann, Peter, Schwarz, Ryan S., Schmid-Hempel, Regula, de Graaf, Dirk, Higes, Mariano, Kadowaki, Tatsuhiko, Wenseleers, Tom, Yañez, Orlando, De Smet, Lina   +19 more
core   +1 more source

Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Protein Science, Volume 35, Issue 7, July 2026.
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli, Sabino Todisco, Margherita Ortalli, Jairo Alfonso Mendoza‐Roldan, Valeria Scaglione, Maria Noemi Sgobba, Lorenzo Guerra, Federica Belluti, Stefania Varani, Domenico Otranto, Anna De Grassi, Mariateresa Volpicella, Ciro Leonardo Pierri   +15 more
wiley   +1 more source