Results 51 to 60 of about 9,059 (176)

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Development of trypanosomatids in the phytophagous insect Dysdercus peruvianus (Hemiptera: Pyrrochoridae): a light and eletron microscopic study

Memorias do Instituto Oswaldo Cruz, 1994
Experimental infections of the phytophagous Hemiptera Dysdercus peruvianus with different trypanosomatids were studied for up to 55 days by light microscopy while the course of infection with Leptomonas seymouri and the Leptomonas isolate 49/553G.O.
Rosa Maria Moraes, Edna Freymuller, Erney Plessamann Camargo, Regina Milder   +3 more
doaj   +1 more source

Monoxenous trypanosomatids of invertebrates [PDF]

, 2017
The class Kinetoplastea contains free-living and parasitic species. One of the most dominant group within the class is the order Trypanosomatida which includes obligate parasites (Trypanosoma, Leishmania) infecting a wide range of hosts. Some species are
Havlová, Jolana
core  

DNA Double-Strand Breaks: A Double-Edged Sword for Trypanosomatids

, 2021
For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the most deleterious types of DNA lesions. DSB processing and repair can cause sequence deletions, loss of heterozygosity, and chromosome rearrangements resulting in ...
da Silva, Marcelo Santos [UNESP]
core   +1 more source

ProtozoaDB 2.0: A Trypanosoma Brucei Case Study

Pathogens, 2017
Over the last decade new species of Protozoa have been sequenced and deposited in GenBank. Analyzing large amounts of genomic data, especially using Next Generation Sequencing (NGS), is not a trivial task, considering that researchers used to deal or ...
Rodrigo Jardim, Diogo Tschoeke, Alberto M. R. Dávila   +2 more
doaj   +1 more source

Microbiome‐mediated chemical communication in insects: Implications for pest management

Pest Management Science, Volume 82, Issue 9, Page 8132-8151, September 2026.
Microbiome–semiochemical interactions involve the following processes: direct microbial synthesis, host gene regulation, precursor biotransformation, microbiome modulation and indirect ecological signaling. Abstract Insects rely on semiochemicals to regulate aggregation, mating, foraging, and host selection. This review synthesizes evidence that insect‐
Ioannis Eleftherianos, Wei Zhang, Amr Mohamed, Rasha K. Al‐Akeel, Abeer M. Alkhaibari, Nemat Keyhani, Guy Smagghe   +6 more
wiley   +1 more source

Different Transcriptomic Responses After Moderate and Severe Heat Shock in Trypanosoma cruzi Epimastigotes

Journal of Eukaryotic Microbiology, Volume 73, Issue 5, September/October 2026.
ABSTRACT Trypanosoma cruzi undergoes heat stress during its life cycle. In this study, we performed a transcriptomic analysis of the heat shock response in epimastigotes from different T. cruzi strains. In both clone CL Brener and the Y strain, very few to no statistically significant variations were observed in the transcriptome at 37°C, whereas ...
Thayane Bottaro, Luciana L. Penha, Rosane Silva, Turán P. Ürményi   +3 more
wiley   +1 more source

Canine Leishmaniosis in Italy: Geospatial Trends and Incidence, a Shift in Epidemiological Approach

Zoonoses and Public Health, Volume 73, Issue 6, Page 584-593, September 2026.
ABSTRACT Introduction Canine leishmaniosis (CanL) has shown a marked geographic expansion in Italy, progressively affecting central and northern regions previously considered non‐endemic. Laboratory‐based prevalence estimates remain informative in well‐designed surveys; however, prevalence derived from diagnostic submissions may be influenced by study ...
Federica Bruno, Germano Castelli, Eugenia Oliveri, Gaetano Oliva, Mariele De Santi, Claudia La Rocca, Ornella Melideo, Marco Ripamonti, Francesco La Russa, Maria Liliana Di Pasquale, Antonella Galante, Roberto Hamel, Giorgio Schiera, Marzio Cometa, Silvia Scibetta, Stefano Reale, Fabrizio Vitale   +16 more
wiley   +1 more source

Short communication: Survival of honey bees (Apis mellifera) infected with Crithidia mellificae (Langridge and McGhee: ATCC® 30254™) in the presence of Nosema ceranae

Spanish Journal of Agricultural Research, 2016
Crithidia mellificae, a trypanosomatid parasite of Apis mellifera, has been proposed to be one of the pathogens responsible for the serious honey bee colony losses produced worldwide in the last decade, either alone or in association with Nosema ceranae.
Mariano Higes, Cristina Rodríguez-García, Tamara Gómez-Moracho, Aranzazu Meana, Carolina Bartolomé, Xulio Maside, Laura Barrios, Raquel Martín-Hernández   +7 more
doaj   +1 more source

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source