Results 31 to 40 of about 5,899 (137)
The surface charge of trypanosomatids
Anais da Academia Brasileira de Ciências, 2002 The surface charge of trypanosomatids was evaluated by means of the binding of cationic particles, as visualized by electron microscopy and by direct measurements of the electrophoretic mobility of cells.
SOUTO-PADRÓN THAÏS
doaj
Pre-mRNA trans-splicing: from kinetoplastids to mammals, an easy language for life diversity
Memorias do Instituto Oswaldo Cruz, 2005 Since the discovery that genes are split into intron and exons, the studies of the mechanisms involved in splicing pointed to presence of consensus signals in an attempt to generalize the process for all living cells. However, as discussed in the present
Mario Gustavo Mayer +1 more
doaj +1 more source
ChemBioChem, Volume 27, Issue 15, 14 August 2026.Organometallic derivatization of existing drugs is a common strategy to look for new drug candidates. This work describes the derivatization of the benzimidazole anthelmintic scaffold, from the synthesis of the organometallic derivatives to the evaluation of their biological properties. It highlights a broad range of antiparasitic activities and leaves
Corentin Ludwig +14 more
wiley +1 more source
Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre +13 more
wiley +1 more source
A Stroll Through the History of Monoxenous Trypanosomatids Infection in Vertebrate Hosts
Frontiers in Cellular and Infection Microbiology, 2022 The Trypanosomatidae family encompasses unicellular flagellates and obligate parasites of invertebrates, vertebrates, and plants. Trypanosomatids are traditionally divided into heteroxenous, characterized by the alternation of the life cycle between an ...
Carolina Boucinha +6 more
doaj +1 more source
Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi
ChemMedChem, Volume 21, Issue 13, 14 July 2026.Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto +9 more
wiley +1 more source
Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman +7 more
wiley +1 more source
Frontiers in Immunology, 2018 Mononuclear phagocytes (monocytes, dendritic cells, and macrophages) are among the first host cells to face intra- and extracellular protozoan parasites such as trypanosomatids, and significant expansion of macrophages has been observed in infected hosts.
Philippe Holzmuller +17 more
doaj +1 more source
Protein Science, Volume 35, Issue 7, July 2026.Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone +15 more
wiley +1 more source
Medical and Veterinary Entomology, Volume 40, Issue 2, Page 350-359, June 2026.Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre +7 more
wiley +1 more source