Results 91 to 100 of about 25,661 (227)

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, Volume 293, Issue 6, Page 1681-1707, March 2026.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning in Trypanosoma brucei [PDF]

, 2017
The flagellum and flagellum attachment zone (FAZ) are important cytoskeletal structures in trypanosomatids, being required for motility, cell division and cell morphogenesis.
Baqui, Munira M.A., Da Fonseca, Carol K., Hammarton, Tansy C., Moreira, Bernardo P.   +3 more
core   +1 more source

THE DURATION OF TRYPANOSOME INFECTIONS [PDF]

Archives of Internal Medicine, 1911
I. INTRODUCTION It is well known that trypanosomes may be absent for long periods from the peripheral blood of an animal or of a person suffering from an infection by trypanosomes, and that although no treatment has been given. It also frequently happens that the parasites may reappear, after a more or less lengthy absence, in the blood of persons or ...
openaire   +2 more sources

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

The FEBS Journal, Volume 293, Issue 6, Page 1771-1784, March 2026.
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
Corinne von Känel, Salome Aeschlimann, Michaela Husová, Silke Oeljeklaus, Philip Stettler, Achim Schnaufer, Bettina Warscheid, Alena Zíková, André Schneider   +8 more
wiley   +1 more source

Parasites of the squirrel Sciurus spadiceus (Rodentia: Sciuridae) from Amazonian Brasil, with particular reference to Eimeria damnosa n. sp. (Apicomplexa: Eimeriidae)

Parasite, 2005
A description is given of the mature oocysts and endogenous stages of Eimeria damnosa n. sp. from the small intestine of the red squirrel, Sciurus spadiceus, from the State of Acre, north Brazil. Ten of 12 animals examined were infected. Oocysts ovoid to
Lainson R., Brigido M.C.O., Silveira F.T.   +2 more
doaj   +1 more source

Cytotoxicity and Antimicrobial Activity of GaMF1 Analogs

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
GaMF1 is a reported, highly potent inhibitor of mycobacterial ATP synthase. Structural modification of this scaffold significantly changes biological activity. We present GaMF1 analogues with strong antiparasitic effects, potential antiproliferative properties, and discuss the selectivity limitations of the parent compound and its analogues.
Jan Chasák, Petr Vyvlečka, Ivan Nemec, An Matheeussen, Natascha Van Pelt, Paul Cos, Guy Caljon, Vladimír Kryštof, Lucie Brulíková   +8 more
wiley   +1 more source

Integrated control of vector-borne diseases of livestock--pyrethroids: panacea or poison?

, 2003
Tick- and tsetse-borne diseases cost Africa approximately US$4-5 billion per year in livestock production-associated losses. The use of pyrethroid-treated cattle to control ticks and tsetse promises to be an increasingly important tool to counter this ...
Coleman, Paul G, Eisler, Mark C, Machila, Noreen, Morton, John F, Torr, Stephen J   +4 more
core   +1 more source

Human African trypanosomiasis [PDF]

, 2009
Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies.
Abel, Agranoff, Ancelle, Ayed, Balasegaram, Balasegaram, Barrett, Barrett, Barrett, Bayer, Bedat-Millet, Bisoffi, Bisser, Bisser, Blum, Blum, Blum, Blum, Blum, Blum, Bronner, Brun, Buguet, Burri, Burri, Chappuis, Chappuis, Chappuis, Chappuis, Chappuis, Chappuis, Checchi, Checchi, Christian Burri, Courtioux, De Raadt, Deborggraeve, Deborggraeve, Dorlo, Doua, Duggan, Dukes, Ekwanzala, Enyaru, Ezzedine, Fevre, Fevre, Francois Chappuis, Greenwood, Gustafsson, Hutchinson, Iborra, Inojosa, Iten, Jamonneau, Jamonneau, Jamonneau, Jamonneau, Jamonneau, Jansson, Jelinek, Johannes Blum, Jordan, Joshi, Kabasa, Kennedy, Kennedy, Koten, Lejon, Lejon, Lejon, Lejon, Lejon, Lejon, Lejon, Lejon, Louis, Lumsden, Lundkvist, Lutumba, Lutumba, Lutumba, Lutumba, MacLean, Macleod, Magnus, Marcello, Marcello, Masocha, Maudlin, Mendonca, Moore, Moore, Moore, Na-Bangchang, Njiokou, Njiru, Noireau, Noireau, Odiit, Odiit, Oscherwitz, Papadopoulos, Paquet, Penchenier, Pepin, Picozzi, Priotto, Priotto, Priotto, Reincke, Reto Brun, Ripamonti, Robays, Robays, Ruiz, Schmid, Shiflett, Simarro, Simarro, Simarro, Simo, Smith, Spencer, Stanghellini, Stevens, Steverding, Steverding, Stijlemans, Stuart, Taylor, Torr, Truc, Truc, Truc, Truc, Van Meirvenne, Van Nieuwenhove, Vanhamme, Vanhollebeke, Vreysen, Welburn, Welburn, Woo   +143 more
core   +2 more sources

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. [PDF]

, 2013
OBJECTIVES: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Aguinaga Andrés, David, Baker, Nicola, Barrett, Michael P, Burchmore, Richard JS, Clucas, Caroline, De Koning, Harry P, Eze, Anthonius A, Glover, Lucy, Graf, Fabrice E, Horn, David, Lee, Rebecca S, Ludin, Philipp, MacLeod, Annette, McDonald, Jennifer, Munday, Jane C, Mäser, Pascal, Natto, Manal J, Tait, Andy, Teka, Ibrahim A, Turner, C Michael R   +19 more
core   +4 more sources

Assessment of animal African trypanosomiasis (AAT) vulnerability in cattle-owning communities of sub-Saharan Africa [PDF]

, 2016
Background: Animal African trypanosomiasis (AAT) is one of the biggest constraints to livestock production and a threat to food security in sub-Saharan Africa.
A Hagos, A Mamoudou, A Mamoudou, A Mamoudou, A Miruk, A Soudré, A Sow, A Teko-Agbo, APM Shaw, C Waiswa, C. Mumba, D Grace, D Muhanguzi, EH Waaij van der, G Cecchi, G Hendrickx, G Rowlands, G. B. Napier, GA Vale, GK Fuller, H Buyst, H Simukoko, H. R. Holt, J Bouyer, J McDermott, J Woodford, J. Guitian, L Sinyangwe, M Abdoulmoumini, M Chanie, M Pinder, M Simon-Grifé, MJB Vreysen, N Machila, N Machila, NE Anderson, OD Cardona, P Bossche Van den, P Solano, PP Simarro, R Fikru, R Selby, R. Selby, S Costard, S Tasew, V Delespaux   +45 more
core   +6 more sources