Results 71 to 80 of about 25,661 (227)

Human infectivity trait in Trypanosoma brucei: stability, heritability and relationship to sra expression [PDF]

, 2004
Some Trypanosoma brucei lines infect humans whereas others do not because the parasites are lysed by human serum. We have developed a robust, quantitative in vitro assay based on differential uptake of fluorescent dyes by live and dead trypanosomes to ...
Bisoni, L., Lindergard, L.A.G., MacLeod, A., McLellan, S., Tait, A., Turner, C.M.R.   +5 more
core   +1 more source

Polymerase Chain Reaction. Perturbation Theory and Machine Learning Artificial Intelligence‐Experimental Microbiome Analysis: Applications to Ancient DNA and Tree Soil Metagenomics Cases of Study

Advanced Intelligent Systems, Volume 8, Issue 4, April 2026.
The polymerase chain reaction (PCR).Perturbation Theory and Machine Learning framework integrates perturbation theory and machine learning to classify genetic sequences, distinguishing ancient DNA from modern controls and predicting tree health from soil metagenomic data.
Jose L. Rodriguez, Estefania Ascencio, Jose M. Ageitos, Lucia Feijoo, Shan He, Amirreza Daghighi, Gerardo M. Casanola‐Martin, Cristian R. Munteanu, Santiago Rodriguez Yañez, Alejandro Pazos, Harbil Bediaga, Brenda Durand Ordiales, Raquel Esteban, Ana‐Maria Heres, Jorge Curiel Yuste, Lur Epelde, Bakhtiyor Rasulev, Tomas Gonzalez, Sonia Arrasate, Humberto González‐Diaz   +19 more
wiley   +1 more source

The impact of mutation and gene conversion on the local diversification of antigen genes in African trypanosomes [PDF]

, 2012
Patterns of genetic diversity in parasite antigen gene families hold important information about their potential to generate antigenic variation within and between hosts.
Awadalla, Berriman, C. A. Cobbold, D. T. Haydon, E. Gjini, Hutchinson, J. D. Barry, Jackson, Morrison, Parham, Parham, Sawyer, Westesson   +12 more
core   +1 more source

Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9‐Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Effects of PEPCK deficiency in Trypanosoma cruzi bioenergetics and life stages. ABSTRACT Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes—unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets.
Carolina S. D. Vieira, Wei Wang, Fernando Sanchez‐Valdez, Jihyun Lim, Brooke E. White, Camilla G. S. Souza, Rick L. Tarleton, Marcia C. Paes, Natalia P. A. Nogueira   +8 more
wiley   +1 more source

Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei

eLife, 2019
The 96-nm axonemal repeat includes dynein motors and accessory structures as the foundation for motility of eukaryotic flagella and cilia. However, high-resolution 3D axoneme structures are unavailable for organisms among the Excavates, which include ...
Simon Imhof, Jiayan Zhang, Hui Wang, Khanh Huy Bui, Hoangkim Nguyen, Ivo Atanasov, Wong H Hui, Shun Kai Yang, Z Hong Zhou, Kent L Hill   +9 more
doaj   +1 more source

Molecular epidemiology of African sleeping sickness [PDF]

, 2009
Human sleeping sickness in Africa, caused by Trypanosoma brucei spp. raises a number of questions. Despite the widespread distribution of the tsetse vectors and animal trypanosomiasis, human disease is only found in discrete foci which periodically give ...
A. TAIT, G. HIDE, Gibson, Hide, Mehlitz, Morrison   +5 more
core   +2 more sources

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei [PDF]

, 2020
BACKGROUND Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles.
Hide, G, Lai, D-H, Li, F-J, Lun, Z-R, Xu, Z-S   +4 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The Trypanosoma brucei AIR9-like protein is cytoskeleton-associated and is required for nucleus positioning and accurate cleavage furrow placement [PDF]

, 2012
AIR9 is a cytoskeleton-associated protein in Arabidopsis thaliana with roles in cytokinesis and cross wall maturation, and reported homologues in land plants and excavate protists, including trypanosomatids.
Almeida Costa, Cristina, Gibson, Wendy, Hammarton, Tansy, May, Sophie, Peacock, Lori, Robinson, Derrick, Robinson, Derrick R, Tetley, Laurence   +7 more
core   +3 more sources

What Is Your Diagnosis? Blood Smear From a North American Beaver (Castor canadensis)

Veterinary Clinical Pathology, EarlyView.
Lilani Munasinghe, Shanika Kurukulasuriya, Tracy Yuen, Dennilyn Parker, Betty Lockerbie   +4 more
wiley   +1 more source