Results 51 to 60 of about 10,619 (187)

Codon choice directs constitutive mRNA levels in trypanosomes

open access: yeseLife, 2018
Selective transcription of individual protein coding genes does not occur in trypanosomes and the cellular copy number of each mRNA must be determined post-transcriptionally.
Janaina de Freitas Nascimento   +3 more
doaj   +1 more source

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy

open access: yesChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira   +4 more
wiley   +1 more source

Shaping the import system of mitochondria

open access: yeseLife, 2018
Evidence is accumulating that unrelated species have independently evolved the same way of importing proteins in their mitochondria.
Kostas Tokatlidis
doaj   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

open access: yesApplied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman   +7 more
wiley   +1 more source

Temperature Alters Specificity in a Host–Parasite Interaction

open access: yesEcology and Evolution, Volume 16, Issue 7, July 2026.
The Red Queen Hypothesis predicts that host–parasite coevolution maintains genetic variation through strong genetic specificity, but this specificity may be sensitive to environmental conditions. Using Meloidogyne arenaria and its parasite Pasteuria penetrans, we tested host–parasite interactions across three temperatures and found specificity at two ...
Abbey Ramirez, Amanda Gibson
wiley   +1 more source

Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei

open access: yeseLife, 2019
The 96-nm axonemal repeat includes dynein motors and accessory structures as the foundation for motility of eukaryotic flagella and cilia. However, high-resolution 3D axoneme structures are unavailable for organisms among the Excavates, which include ...
Simon Imhof   +9 more
doaj   +1 more source

Environmental Drivers on Blue Tit Nest Microbiome: An Experimental Study

open access: yesEcology and Evolution, Volume 16, Issue 7, July 2026.
Elevated humidity and temperature altered nest microbial composition and its associations with parasitism and nestling condition. These findings identify nest microclimate as an important driver of nest microbiomes with consequences for avian development.
Marina García‐del Río   +7 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

open access: yesInterdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione   +2 more
wiley   +1 more source

Microbial Pressure and Social Immunity: Bumble Bees Increase Brood Hygiene After Exposure to a Bacillus thuringiensis‐Based Biopesticide

open access: yesEcology and Evolution, Volume 16, Issue 6, June 2026.
In social insect colonies, diseased or dead brood is identified and removed by workers to prevent the infection of the whole colony. Here, bumble bee larvae exposed to a bacterium (Bacillus thuringiensis ssp. aizawai (strain: ABTS‐1857)) based biopesticide were removed more frequently than wounded or untreated control larvae. This shows that bumble bee
Michelle Scheffler   +4 more
wiley   +1 more source

What Is Your Diagnosis? Blood Smear From a North American Beaver (Castor canadensis)

open access: yes
Veterinary Clinical Pathology, EarlyView.
Lilani Munasinghe   +4 more
wiley   +1 more source

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