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African trypanosomes: celebrating diversity
Trends in Parasitology, 2010Recent advances in molecular identification techniques and phylogenetic analysis have revealed the presence of previously unidentified tsetse-transmitted trypanosomes in Africa. This is surprising in a comparatively well-known group of pathogens that includes the causative agents of human and animal trypanosomiasis. Despite levels of genetic divergence
Adams, ER, Hamilton, PB, Gibson, WC
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1999
Abstract As mentioned, the trypanosomes are closely related to the leishmaniae, and their zoologic classification follows the same lines (see Chapter 4; Corliss, 1994). Trypanosomes are known in general as the blood flagellates, and under natural conditions they occur in humans and many other species of animals.
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Abstract As mentioned, the trypanosomes are closely related to the leishmaniae, and their zoologic classification follows the same lines (see Chapter 4; Corliss, 1994). Trypanosomes are known in general as the blood flagellates, and under natural conditions they occur in humans and many other species of animals.
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Antigenic Variation in Trypanosomes
The American Journal of Tropical Medicine and Hygiene, 1977The several species of African trypanosomes pathogenic to man and domestic livestock may evade the immune response through a process of antigenic variation. This phenomenon is the major obstacle to immunization. Variation may be recognized in the form of sequential changes in the serological characteristics of the trypanosome surface ...
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The African trypanosome genome
International Journal for Parasitology, 2000The haploid nuclear genome of the African trypanosome, Trypanosoma brucei, is about 35 Mb and varies in size among different trypanosome isolates by as much as 25%. The nuclear DNA of this diploid organism is distributed among three size classes of chromosomes: the megabase chromosomes of which there are at least 11 pairs ranging from 1 Mb to more than
N M, El-Sayed +4 more
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Antigenic variation of trypanosomes
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1985Etude de la biologie des trypanosomes et de la variation antigenique. Synthese des VSGS et structure de la paroi externe. Structure des telomeres, organisation chromosomique, specificite des genes telomeriques, activation non duplicative, conversion des telomeres transcription chez les trypanosomatides, controle des sites d'expression ...
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Antigenic variation in trypanosomes
Nature, 1978In its mammalian host, Trypanosoma brucei is able to change the antigenic character of its glycoprotein surface coat and so evade the host's immune response. This phenotypic change seems to occur spontaneously in 1 in 10,000 individuals but is not due to genetic mutation: host antibody is not necessary for its induction but plays a selective part in ...
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Antigens of African Trypanosomes
1985The African trypanosomes present their hosts with the best characterised antigens in parasitology — the variant surface glycoproteins, or VSGs. The structure of the genes encoding VSGs and the mechanism by which the expression of these genes is regulated have been studied intensively (reviewed in Steinert and Pays 1985). Research in this area is at the
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Cyclic AMP signalling and glucose metabolism mediate pH taxis by African trypanosomes
Nature Communications, 2022Sebastian Shaw +2 more
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