Results 71 to 80 of about 25,093 (176)

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

A histone methyltransferase modulates antigenic variation in African trypanosomes [PDF]

, 2008
To evade the host immune system, several pathogens periodically change their cell-surface epitopes. In the African trypanosomes, antigenic variation is achieved by tightly regulating the expression of a multigene family encoding a large repertoire of ...
Janzen, Christian J., Figueiredo Luisa M, Cross, George A. M., Figueiredo, Luisa M., Cross George A.M, Luisa M Figueiredo, Christian J Janzen, George A M Cross, Janzen Christian J   +8 more
core   +1 more source

Characterization of trypanosomes in N’Dama cattle of Mushie ranch in the Democratic Republic of the Congo

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2019
A transverse and descriptive study was conducted from 3 August to 5 September 2014 and from 6 February to 7 March 2015 at the Izeli area of the Mushie ranch in the Democratic Republic of Congo, to identify trypanosome species and determine the ...
Edouard Telamanu BAFWANGA, Anicet Ilaka NZASHILUMENGU, Willy Kabamba MWAMBA   +2 more
doaj  

Host Call Frequency Drives Attractiveness to an Eavesdropping Micropredator

Ecology and Evolution, Volume 16, Issue 9, September 2026.
Acoustic sexual signals are vulnerable to interception by eavesdropping unintended receivers, and signals are thus influenced by interacting selection pressures. Frequencies of 0.5–1.4 kHz attracted frog‐biting midges (Corethrella spp.) and closely matched the lowest‐calling local frog species.
Timothy P. Cutajar, Alistair G. B. Poore, Jodi J. L. Rowley   +2 more
wiley   +1 more source

Identification and lineage genotyping of South American trypanosomes using fluorescent fragment length barcoding.

, 2011
Trypanosoma cruzi and Trypanosoma rangeli are human-infective blood parasites, largely restricted to Central and South America. They also infect a wide range of wild and domestic mammals and are transmitted by a numerous species of triatomine bugs. There
S.A. Valente, HAMILTON, P. B., C. Cruickshank, Cruickshank, C, YEO, M., Hamilton, PB, M.S. Llewellyn, GAUNT, M. W., LEWIS, M. D., Yeo, M, M. Yeo, SILVA, F. Maia da, F. Maia da Silva, MILES, M. A., Stevens, JR, J.R. Stevens, M.W. Gaunt, VALENTE, S. A., LLEWELLYN, M. S., Gaunt, MW, P.B. Hamilton, Lewis, MD, Llewellyn, MS, Miles, MA, Teixeira, MMG, TEIXEIRA, M. M. G., Maia da Silva, F, STEVENS, J. R., CRUICKSHANK, C., M.D. Lewis, M.A. Miles, Valente, SA   +31 more
core   +1 more source

Trypanosome motion represents an adaptation to the crowded environment of the vertebrate bloodstream [PDF]

, 2012
Blood is a remarkable habitat: it is highly viscous, contains a dense packaging of cells and perpetually flows at velocities varying over three orders of magnitude. Only few pathogens endure the harsh physical conditions within the vertebrate bloodstream
Timothy Krüger, Stark Holger, Engstler Markus, Engstler, M., Heddergott, Niko, Wei, Ai, Sravanti Uppaluri (120013), Erik Stellamanns, Pfohl, T., Stellamanns, E., Heddergott, Nico, Holger Stark, Uppaluri, Sravanti, Wei, A., Markus Engstler, Krüger, T., Engstler, Markus, Heddergott, N., Pfohl Thomas, Babu Sujin B., Krüger Timothy, Babu, Sujin B., Holger Stark (4694), Markus Engstler (120018), Sujin B Babu, Niko Heddergott (120004), Ai Wei, Sujin B. Babu (120007), Stellamanns, Erik, Sravanti Uppaluri, Erik Stellamanns (120012), Stark, H., Stark, Holger, Babu, S., Pfohl, Thomas, Uppaluri, S., Thomas Pfohl (120015), Beverley, Stephen M., Stellamanns Erik, Krüger, Timothy, Wei Ai, Niko Heddergott, Uppaluri Sravanti, Ai Wei (120010), Heddergott Niko, Thomas Pfohl, Timothy Krüger (120005)   +46 more
core   +1 more source

Identification of New Anti‐Trypanosoma brucei Leads: An Integrated CRK12‐Guided Virtual Screen With Experimental Validation

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
An integrated computational‐experimental workflow enabled CRK12‐guided hit discovery against Trypanosoma brucei under limited structural and ligand data. The workflow of virtual screening and anti‐T. brucei bioassays identified 4 hit compounds, including three low‐micromolar leads (IC50 = 1.47, 0.81, and 1.33 μM). ABSTRACT Human African trypanosomiasis
Qin Li, Chenggong Fu, Jiayi Luo, Qianqian Zhang, Lingling Wang, Xiaomeng Liu, Jiayue Qiu, Xiaoqing Gong, Henry H. Y. Tong, Xiaojun Yao, Dehua Lai, Huanxiang Liu   +11 more
wiley   +1 more source

Extravascular trypanosomes and organ-specific symptoms in humans and animals.

, 2021
(A) Organs in which extravascular trypanosomes have been observed in animal models. (B) Organ-specific symptoms of HAT, which may be associated with extravascular trypanosomes. (Created with Biorender.com). HAT, human African trypanosomiasis.
Monica R. Mugnier (11441876), Nathan P. Crilly (11441873)   +1 more
core   +1 more source

Biology and ultrastructure of trypanosomes in relation to pathogenesis

, 1978
Meeting: Conference on Recent Advances in the Knowledge of Pathogenicity of Trypanosomes, 20-23 Nov.
Vickerman, K., Tetley, L.
core   +1 more source

Disruption of Circadian Rhythms in Synaptic Activity of the Suprachiasmatic Nuclei by African Trypanosomes and Cytokines

Neurobiology of Disease, 2002
Disturbances in biological rhythms pose a major disease problem, not the least in the aging population. Experimental sleeping sickness, caused by Trypanosoma brucei brucei, in rats constitutes a unique and robust chronic model for studying mechanisms of ...
G.B. Lundkvist, R.H. Hill, K. Kristensson   +2 more
doaj   +1 more source