Results 51 to 60 of about 25,093 (176)

A multigene family encoding surface glycoproteins in Trypanosoma congolense

Microbial Cell, 2017
Trypanosoma congolense, the causative agent of the most important livestock disease in Africa, expresses specific surface proteins involved in its parasitic lifestyle. Unfortunately, the complete repertoire of such molecules is far from being deciphered.
Magali Thonnus, Amandine Guéri, Loïc Rivière   +2 more
doaj   +1 more source

Rescue of pATOM36‐depleted T. brucei by human MTCH1/2 reveals common features of protein insertases

The FEBS Journal, EarlyView.
Human MTCH1 and MTCH2 (with an N‐terminal extension) functionally complement the loss of pATOM36 in T. brucei, indicating that these evolutionarily distant proteins recognize a common set of substrates and share fundamental principles of mitochondrial outer membrane protein insertion. Structural analyses reveal a common hydrophilic cavity, supporting a
Stephan Berger, Markus Daniel Gerber, Torsten Ochsenreiter, Christoph von Ballmoos, André Schneider   +4 more
wiley   +1 more source

Activation of endocytosis as an adaptation to the mammalian host by trypanosomes [PDF]

, 2007
Immune evasion in African trypanosomes is principally mediated by antigenic variation, but rapid internalization of surface-bound immune factors may contribute to survival.
Peacock, Lori, Field, Mark C, Natesan, Senthil Kumar A, Matthews, Keith; id_orcid, Gibson, Wendy   +4 more
core   +1 more source

Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages

Frontiers in Immunology, 2019
African trypanosomes, such as Trypanosoma brucei (T. brucei), are protozoan parasites of the mammalian vasculature and central nervous system that are best known for causing fatal human sleeping sickness.
Nicole K. Campbell, David G. Williams, Hannah K. Fitzgerald, Paul J. Barry, Clare C. Cunningham, Derek P. Nolan, Aisling Dunne, Aisling Dunne   +7 more
doaj   +1 more source

Peridomestic infestation by Triatoma pallidipennis and natural infection with Trypanosoma cruzi in Zacatepec, Morelos, Mexico Infestación peridoméstica por Triatoma pallidipennis e infección natural por Trypanosoma cruzi en Zacatepec, Morelos, México

Medical and Veterinary Entomology, EarlyView.
Entomological and community‐related risk factors for Chagas disease were assessed through peridomestic sampling, calculation of entomological indices and surveys of community knowledge, attitudes and practices. Forty‐six triatomines, all identified as Triatoma pallidipennis, were collected, and all specimens showed natural infection with Trypanosoma ...
Reyna Vargas‐Abasolo, José Rafael Delgado López, Liliana Aguilar‐Marcelino, Miguel Galarde‐López, Gemma Rojo, Alex Córdoba‐Aguilar   +5 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, Volume 16, Issue 10, Page 1974-1981, October 2026.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei [PDF]

, 2005
<i>Trypanosoma brucei</i>, the parasite causing human sleeping sickness, relies on the tsetse fly for its transmission. In the insect, EP and GPEET procyclins are the major surface glycoproteins of procyclic (midgut) forms of the parasite ...
J. David Barry, Blundell, Pat, Erik Vassella, Isabel Roditi, Blundell, P., Simon Urwyler, Abbeele Jan Van Den, Urwyler, Simon, Pat Blundell, Roditi Isabel, Vassella, Erik, Barry, J. David, Barry, J. D., Kunz Renggli, Christina, Abbeele, Jan Van Den, Barry, J.D., Roditi, Isabel, Jan Van Den Abbeele, Urwyler Simon, J David Barry, Van den Abbeele, J., Roditi, I., Abbeele, J.V.D., Kunz Renggli, C., Renggli Christina Kunz, Christina Kunz Renggli, Barry J. David, Vassella, E., Urwyler, S., Vassella Erik, Blundell Pat, Vassella E, Van Den Abbeele J, Roditi I, Urwyler S, Barry JD, Renggli CK, Blundell P   +37 more
core   +3 more sources

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Molecules, 2016
Glucose-6-phosphate dehydrogenase (G6PDH) plays a housekeeping role in cell metabolism by generating reducing power (NADPH) and fueling the production of nucleotide precursors (ribose-5-phosphate).
Cecilia Ortiz, Francesca Moraca, Andrea Medeiros, Maurizio Botta, Niall Hamilton, Marcelo A. Comini   +5 more
doaj   +1 more source

Harnessing Extracellular Vesicles for Precision Diagnostics and Infectious Disease Management: Integrating Host‐ and Pathogen‐Derived Cues

Exploration, Volume 6, Issue 5, October 2026.
This review summarizes the diagnostic and monitoring potential of host‐pathogen extracellular vesicles (hpEVs) in infectious diseases, advances in their isolation and analysis, and challenges to clinical translation. ABSTRACT Conventional infectious disease diagnostics often rely on detecting pathogen‐derived factors or an immune response directed ...
Ming Zhou, Yongchun Pan, Bo Ning, Christopher J. Lyon, Yang Liu, Tony Hu   +5 more
wiley   +1 more source

Environmental sensing by African trypanosomes [PDF]

, 2016
African trypanosomes, which divide their life cycle between mammals and tsetse flies, are confronted with environments that differ widely in temperature, nutrient availability and host responses to infection.
Naguleswaran, Arunasalam, Isabel Roditi, Roditi, Isabel, Arunasalam Naguleswaran, Schumann-Burkard, Gabriela, Gabriela Schumann, Roditi I, Naguleswaran A, Schumann G   +8 more
core   +1 more source