Results 61 to 70 of about 11,194 (175)

The exquisite mechanics of a tsetse bite

eLife
Specialized anatomical structures in the mouth and feet of tsetse flies help them feed on blood from a variety of hosts.
Katelyn Fealy, Álvaro Acosta-Serrano
doaj   +1 more source

Trypanosomal MICOS Is Assembled on Non‐Respiring Mitochondrial Crista Precursors and Associates With Two Integral Microproteins

Molecular Microbiology, EarlyView.
The mitochondrial membrane‐shaping machinery MICOS is assembled surprisingly early during the life cycle of Trypanosoma brucei, before the mitochondrion acquires its mature architecture or full respiratory capacity. Our study also identifies two previously uncharacterized proteins associated with MICOS, providing new insight into the early organization
Michala Boudová, Teresa Wagner, Tomáš Bílý, Martina Tesařová, Corinna Benz, Hassan Hashimi   +5 more
wiley   +1 more source

A multigene family encoding surface glycoproteins in Trypanosoma congolense

Microbial Cell, 2017
Trypanosoma congolense, the causative agent of the most important livestock disease in Africa, expresses specific surface proteins involved in its parasitic lifestyle. Unfortunately, the complete repertoire of such molecules is far from being deciphered.
Magali Thonnus, Amandine Guéri, Loïc Rivière   +2 more
doaj   +1 more source

Peridomestic infestation by Triatoma pallidipennis and natural infection with Trypanosoma cruzi in Zacatepec, Morelos, Mexico Infestación peridoméstica por Triatoma pallidipennis e infección natural por Trypanosoma cruzi en Zacatepec, Morelos, México

Medical and Veterinary Entomology, EarlyView.
Entomological and community‐related risk factors for Chagas disease were assessed through peridomestic sampling, calculation of entomological indices and surveys of community knowledge, attitudes and practices. Forty‐six triatomines, all identified as Triatoma pallidipennis, were collected, and all specimens showed natural infection with Trypanosoma ...
Reyna Vargas‐Abasolo, José Rafael Delgado López, Liliana Aguilar‐Marcelino, Miguel Galarde‐López, Gemma Rojo, Alex Córdoba‐Aguilar   +5 more
wiley   +1 more source

Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages

Frontiers in Immunology, 2019
African trypanosomes, such as Trypanosoma brucei (T. brucei), are protozoan parasites of the mammalian vasculature and central nervous system that are best known for causing fatal human sleeping sickness.
Nicole K. Campbell, David G. Williams, Hannah K. Fitzgerald, Paul J. Barry, Clare C. Cunningham, Derek P. Nolan, Aisling Dunne, Aisling Dunne   +7 more
doaj   +1 more source

Community Health Workers' Multiple Understandings of Schistosomiasis Transmission Pathways: Exploring Contextual Factors in Côte d'Ivoire, Kenya and Uganda

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objective Schistosomiasis remains a public health concern in sub‐Saharan Africa, affecting over 250 million people. In endemic settings, schistosomiasis transmission is not always understood exclusively in biomedical terms. Community health workers (CHWs) contribute to schistosomiasis control through mass drug administration and health ...
Dianne Verhoeven, Lisa Sophie Reigl, Alice Sereti Sinkeet, Mary Maghanga, Alexise Djouquou Gnahore, Bi Tra Jamal Sehi, Suzanne Lobohon Lavry, Andrea Buhl, Marie Frese, Jennifer Burrill, Eveline Hürlimann, Peter Steinmann, Nora Monnier, Ashley Preston, Janet Masaku, Matthias Richter, Mary Amuyunzu Nyamongo, Alain Toh, Stella Neema, Isabelle L. Lange, Andrea S. Winkler, on behalf of the Pediatric Praziquantel Consortium   +21 more
wiley   +1 more source

Antigenic variation in African trypanosomes [PDF]

, 2014
Studies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the African trypanosome, Trypanosoma brucei, have yielded a remarkable range of novel and important insights. The features first identified in T.
Horn, David; id_orcid
core   +1 more source

Replicative slender bloodstream forms complete transmission of Trypanosoma brucei without prior differentiation into stumpy forms

eLife
We have previously shown that the slender form of Trypanosoma (T.) brucei is able to infect teneral tsetse flies, develop to the first fly form, which is the procyclic form, and complete the life cycle in the insect vector (Schuster et al., 2021 ...
Carina Praisler, Jaime N Lisack, Anna Sophie Kreis, Laura Hauf, Johanna Odenwald, Fabian Imdahl, Markus Engstler   +6 more
doaj   +1 more source

A histone methyltransferase modulates antigenic variation in African trypanosomes [PDF]

, 2008
To evade the host immune system, several pathogens periodically change their cell-surface epitopes. In the African trypanosomes, antigenic variation is achieved by tightly regulating the expression of a multigene family encoding a large repertoire of ...
Janzen, Christian J., Figueiredo Luisa M, Cross, George A. M., Figueiredo, Luisa M., Cross George A.M, Luisa M Figueiredo, Christian J Janzen, George A M Cross, Janzen Christian J   +8 more
core   +1 more source

Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

International Journal for Parasitology: Drugs and Drug Resistance
Earlier evidences showed that diglycosyl diselenides are active against the infective stage of African trypanosomes (top hits IC50 0.5 and 1.5 μM) but poorly selective (selectivity index 38-folds vs. murine and human macrohages).
Estefanía Dibello, Natalia Oddone, Jaime Franco, Tünde-Zita Illyés, Andrea Medeiros, Attila Kiss, Fanni Hőgye, Katalin E. Kövér, László Szilágyi, Marcelo A. Comini   +9 more
doaj   +1 more source