Results 41 to 50 of about 50,381 (267)

A single test approach for accurate and sensitive detection and taxonomic characterization of Trypanosomes by comprehensive analysis of internal transcribed spacer 1 amplicons

PLoS Neglected Tropical Diseases, 2019
To improve our knowledge on the epidemiological status of African trypanosomiasis, better tools are required to monitor Trypanosome genotypes circulating in both mammalian hosts and tsetse fly vectors.
A. Gaithuma, J. Yamagishi, A. Martinelli, K. Hayashida, Naoko Kawai, Megasari Marsela, C. Sugimoto   +6 more
semanticscholar   +1 more source

A systematic review and meta-analysis of trypanosome prevalence in tsetse flies [PDF]

, 2017
Background: The optimisation of trypanosomosis control programs warrants a good knowledge of the main vector of animal and human trypanosomes in sub-Saharan Africa, the tsetse fly.
Abdi, Reta D, Agga, Getahun E, Aregawi, Weldegebrial G, Bekana, Merga, Delespaux, Vincent, Duchateau, Luc, Van Leeuwen, Thomas   +6 more
core   +2 more sources

Tissue tropism in parasitic diseases [PDF]

Open Biology, 2019
Parasitic diseases, such as sleeping sickness, Chagas disease and malaria, remain a major cause of morbidity and mortality worldwide, but particularly in tropical, developing countries.
Sara Silva Pereira, Sandra Trindade, Mariana De Niz, Luisa M. Figueiredo   +3 more
doaj   +1 more source

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome. [PDF]

FEBS J
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
von Känel C, Aeschlimann S, Husová M, Oeljeklaus S, Stettler P, Schnaufer A, Warscheid B, Zíková A, Schneider A.   +8 more
europepmc   +2 more sources

Allelic segregation and independent assortment in T. brucei crosses: proof that the genetic system is Mendelian and involves meiosis [PDF]

, 2005
The genetic system on Trypanosoma brucei has been analysed by generating large numbers of independent progeny clones from two crosses, one between two cloned isolates of Trypanosoma brucei brucei and one between cloned isolates of T. b.
Annette MacLeod, Alison Tweedie, Sarah McLellan, Sonya Taylor, Anneli Cooper, Lindsay Sweeney, C. Michael R. Turner, Andy Tait, Hoare, Gibson, Tibayrenc, MacLeod, MacLeod, MacLeod, Gibson, Turner, Jenni, Sternberg, Gibson, Tait, Gibson, Le Page, Paindovoine, Hope, Su, Su, Martinelli, Culleton, Martinelli, Su, Shirley, Tait, MacLeod, El-Sayed, Hall, Benson, Gaunt, Tait, Gibson, Schweizer, Gibson, Gibson, Hassold, Hide, Van Den Abbeele   +44 more
core   +1 more source

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei [PDF]

, 2020
BACKGROUND Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles.
Hide, G, Lai, D-H, Li, F-J, Lun, Z-R, Xu, Z-S   +4 more
core   +2 more sources

Imaging African trypanosomes [PDF]

Parasite Immunology, 2013
SummaryTrypanosoma brucei are extracellular kinetoplastid parasites transmitted by the blood‐sucking tsetse fly. They are responsible for the fatal disease human African trypanosomiasis (HAT), also known as sleeping sickness. In late‐stage infection, trypanosomes cross the blood–brain barrier (BBB) and invade the central nervous system (CNS) invariably
MacLean, L., Myburgh, E., Rodgers, J., Price, H.P.   +3 more
openaire   +3 more sources

Molecular Detection of Trypanosoma spp. in Questing and Feeding Ticks (Ixodidae) Collected from an Endemic Region of South-West Australia

Pathogens, 2021
A growing number of indigenous trypanosomes have been reported to naturally infect a variety of Australian wildlife with some species of Trypanosoma implicated in the population decline of critically endangered marsupials.
Anna-Sheree Krige, R. C. Andrew Thompson, Anke Seidlitz, Sarah Keatley, Julia Wayne, Peta L. Clode   +5 more
doaj   +1 more source

Visualizing trypanosomes in a vertebrate host reveals novel swimming behaviours, adaptations and attachment mechanisms

eLife, 2019
Trypanosomes are important disease agents of humans, livestock and cold-blooded species, including fish. The cellular morphology of trypanosomes is central to their motility, adaptation to the host’s environments and pathogenesis.
É. Dóró, S. H. Jacobs, Ffion R. Hammond, H. Schipper, Remco P. M. Pieters, M. Carrington, G. Wiegertjes, M. Forlenza   +7 more
semanticscholar   +1 more source

Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes [PDF]

, 1990
The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire.
Barry, J D, Graham, S V, Matthews, K R, Shiels, P G   +3 more
core   +1 more source