Results 41 to 50 of about 25,093 (176)

Influence of the Draining Lymph Nodes and Organized Lymphoid Tissue Microarchitecture on Susceptibility to Intradermal Trypanosoma brucei Infection

Frontiers in Immunology, 2020
Infection of the mammalian host with African trypanosomes begins when the tsetse fly vector injects the parasites into the skin dermis during blood feeding.
Omar A. Alfituri, Barry M. Bradford, Edith Paxton, Liam J. Morrison, Neil A. Mabbott   +4 more
doaj   +1 more source

Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

International Journal for Parasitology: Drugs and Drug Resistance
Earlier evidences showed that diglycosyl diselenides are active against the infective stage of African trypanosomes (top hits IC50 0.5 and 1.5 μM) but poorly selective (selectivity index 38-folds vs. murine and human macrohages).
Estefanía Dibello, Natalia Oddone, Jaime Franco, Tünde-Zita Illyés, Andrea Medeiros, Attila Kiss, Fanni Hőgye, Katalin E. Kövér, László Szilágyi, Marcelo A. Comini   +9 more
doaj   +1 more source

Life and times:synthesis, trafficking, and evolution of VSG [PDF]

, 2014
Evasion of the acquired immune response in African trypanosomes is principally mediated by antigenic variation, the sequential expression of distinct variant surface glycoproteins (VSGs) at extremely high density on the cell surface.
Boehm, Cordula, Cordula Boehm, Senthil Kumar Natesan, Paul T. Manna, Ka Fai Leung, Natesan, Senthil Kumar, Field, Mark C., Leung, Ka Fai, Mark C. Field, Manna, Paul T.   +9 more
core   +1 more source

The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins

Pathogens, 2017
Lipid rafts are liquid-ordered membrane microdomains that form by preferential association of 3-β-hydroxysterols, sphingolipids and raft-associated proteins often having acyl modifications.
Aabha I. Sharma, Cheryl L. Olson, David M. Engman   +2 more
doaj   +1 more source

Predicting Mammal Species Suitable for Chagas Disease Spread Using a Machine‐Learning Framework

Integrative Zoology, EarlyView.
Chagas disease is maintained in wildlife by Trypanosoma cruzi cycling among many mammal species, but we still do not know the full range of potential hosts. Using machine learning and ecological/behavioral traits, we found that kissing bugs overlap with 573 mammal species and tend to feed on mammals that are den‐dwelling, medium‐to‐large in size, and ...
Maya Rocha‐Ortega, Carezza Botto‐Mahan, Gemma Rojo, Alex Córdoba‐Aguilar   +3 more
wiley   +1 more source

Protein tyrosine phosphatase TbPTP1:A molecular switch controlling life cycle differentiation in trypanosomes [PDF]

, 2006
Differentiation in African trypanosomes (Trypanosoma brucei) entails passage between a mammalian host, where parasites exist as a proliferative slender form or a G0-arrested stumpy form, and the tsetse fly.
Szoor, Balazs; id_orcid, Matthews, Keith R., Helen McElhinney, Tabernero, Lydia, Wilson, Jude, Szöor, Balázs, Keith R. Matthews, Matthews, Keith R; id_orcid, Lydia Tabernero, Tabernero, Lydia; id_orcid, McElhinney, Helen, Balázs Szöőr, Jude Wilson   +12 more
core   +1 more source

Infections With Extracellular Trypanosomes Require Control by Efficient Innate Immune Mechanisms and Can Result in the Destruction of the Mammalian Humoral Immune System

Frontiers in Immunology, 2020
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Stefan Magez, Stefan Magez, Stefan Magez, Joar Esteban Pinto Torres, Emmanuel Obishakin, Emmanuel Obishakin, Magdalena Radwanska, Magdalena Radwanska   +7 more
doaj   +1 more source

Fungal infection affects sexual signalling and mate choice in the sugarcane borer

Ecological Entomology, EarlyView.
Fungus‐infected Diatraea saccharalis females exhibit enhanced attractiveness to males in wind tunnel assays. Fungal infection alters the pheromone profile of females, increasing the relative abundance of Z9‐16: Ald, a minor but behaviourally active component of the species' sex pheromone blend.
Amanda C. Tuler, Arodi P. Favaris, Flávia P. Franco, José Mauricio S. Bento   +3 more
wiley   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Using detergent to enhance detection sensitivity of African trypanosomes in human CSF and blood by Loop-Mediated Isothermal Amplification (LAMP) [PDF]

, 2011
<p><b>Background:</b> The loop-mediated isothermal amplification (LAMP) assay, with its advantages of simplicity, rapidity and cost effectiveness, has evolved as one of the most sensitive and specific methods for the detection of a ...
Gibson, W., Thekisoe, Oriel M M, Dumler, JS, Olga V. Nikolskaia, Olga V Nikolskaia, Liam J Morrison, Inoue, N., Noboru Inoue, Liam J. Morrison, Dennis J Grab, Oriel M. M. Thekisoe, Dumler J. Stephen, Grab, DJ, J. Stephen Dumler, Dumler, J.S., J Stephen Dumler, Morrison, L.J., Nikolskaia Olga V., Dumler, J Stephen, Nikolskaia, O.V., Nikolskaia, OV, Grab, D.J., Grab, Dennis J, Wendy Gibson, Morrison Liam J., Grab Dennis J., Inoue, N, Gibson, WC, Thekisoe, Oriel M. M., Oriel M M Thekisoe, Inoue, Noboru, Thekisoe Oriel M. M., Morrison, Liam J; id_orcid, Gibson Wendy, Thekisoe, OMM, Morrison, L, Inoue Noboru, Dennis J. Grab, Nikolskaia, Olga V, Gibson, Wendy   +39 more
core   +1 more source