Results 31 to 40 of about 50,381 (267)

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Trypanothione synthetase (TryS) produces N1,N8-bis(glutathionyl)spermidine (or trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential for survival and drug-resistance of trypanosomatid parasites. In this study, we report
Andrea Medeiros, Diego Benítez, Ricarda S. Korn, Vinicius C. Ferreira, Exequiel Barrera, Federico Carrión, Otto Pritsch, Sergio Pantano, Conrad Kunick, Camila I. de Oliveira, Oliver C. F. Orban, Marcelo A. Comini   +11 more
doaj   +1 more source

(E)-5-(Methoxyimino)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

Molbank, 2021
(E)-5-(Methoxyimino)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one was prepared by a condensation reaction from 3,4-dihydro-1H-benzo[b]azepin-2,5-dione and O-methylhydroxylamine.
Irina Ihnatenko, Peter G. Jones, Conrad Kunick   +2 more
doaj   +1 more source

Trypanosomatids Are Much More than Just Trypanosomes: Clues from the Expanded Family Tree.

Trends in Parasitology, 2018
Trypanosomes and leishmanias are widely known parasites of humans. However, they are just two out of several phylogenetic lineages that constitute the family Trypanosomatidae.
J. Lukeš, A. Butenko, H. Hashimi, D. Maslov, J. Votýpka, V. Yurchenko   +5 more
semanticscholar   +1 more source

Molecular identification of different trypanosome species and subspecies in tsetse flies of northern Nigeria [PDF]

, 2016
Background: Animal African Trypanosomiasis (AAT) is caused by several species of trypanosomes including Trypanosoma congolense, T. vivax, T. godfreyi, T. simiae and T. brucei. Two of the subspecies of T. brucei also cause Human African Trypanosomiasis.
Ciosi, Marc, Dede, Peter, Hamilton, Alana, Igbinosa, Igho Benjamin, Isaac, Clement, Masiga, Dan, Nmorsi, Oyebiguwa Patrick Goddey, Scullion, Kathleen Maria, Turner, C. Michael R.   +8 more
core   +1 more source

Coordination of the Cell Cycle in Trypanosomes.

Annual Review of Microbiology, 2019
Trypanosomes have complex life cycles within which there are both proliferative and differentiation cell divisions. The coordination of the cell cycle to achieve these different divisions is critical for the parasite to infect both host and vector.
R. Wheeler, K. Gull, J. Sunter
semanticscholar   +1 more source

Barcoding in trypanosomes [PDF]

Parasitology, 2017
SUMMARYTrypanosomes (genus Trypanosoma) are parasites of humans, and wild and domestic mammals, in which they cause several economically and socially important diseases, including sleeping sickness in Africa and Chagas disease in the Americas. Despite the development of numerous molecular diagnostics and increasing awareness of the importance of these ...
RACHEL HUTCHINSON, JAMIE R. STEVENS
openaire   +4 more sources

Human African trypanosomiasis [PDF]

, 2009
Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies.
Abel, Agranoff, Ancelle, Ayed, Balasegaram, Balasegaram, Barrett, Barrett, Barrett, Bayer, Bedat-Millet, Bisoffi, Bisser, Bisser, Blum, Blum, Blum, Blum, Blum, Blum, Bronner, Brun, Buguet, Burri, Burri, Chappuis, Chappuis, Chappuis, Chappuis, Chappuis, Chappuis, Checchi, Checchi, Christian Burri, Courtioux, De Raadt, Deborggraeve, Deborggraeve, Dorlo, Doua, Duggan, Dukes, Ekwanzala, Enyaru, Ezzedine, Fevre, Fevre, Francois Chappuis, Greenwood, Gustafsson, Hutchinson, Iborra, Inojosa, Iten, Jamonneau, Jamonneau, Jamonneau, Jamonneau, Jamonneau, Jansson, Jelinek, Johannes Blum, Jordan, Joshi, Kabasa, Kennedy, Kennedy, Koten, Lejon, Lejon, Lejon, Lejon, Lejon, Lejon, Lejon, Lejon, Louis, Lumsden, Lundkvist, Lutumba, Lutumba, Lutumba, Lutumba, MacLean, Macleod, Magnus, Marcello, Marcello, Masocha, Maudlin, Mendonca, Moore, Moore, Moore, Na-Bangchang, Njiokou, Njiru, Noireau, Noireau, Odiit, Odiit, Oscherwitz, Papadopoulos, Paquet, Penchenier, Pepin, Picozzi, Priotto, Priotto, Priotto, Reincke, Reto Brun, Ripamonti, Robays, Robays, Ruiz, Schmid, Shiflett, Simarro, Simarro, Simarro, Simo, Smith, Spencer, Stanghellini, Stevens, Steverding, Steverding, Stijlemans, Stuart, Taylor, Torr, Truc, Truc, Truc, Truc, Van Meirvenne, Van Nieuwenhove, Vanhamme, Vanhollebeke, Vreysen, Welburn, Welburn, Woo   +143 more
core   +2 more sources

The trypanosome flagellum [PDF]

Journal of Cell Science, 2003
African Trypanosomes are flagellated protozoan parasites that cause sleeping sickness in humans and Nagana in cattle. During its life cycle, Trypanosoma brucei alternates between an insect vector (tsetse fly) and a mammalian host.
Vaughan, S, Gull, K
openaire   +2 more sources

Evolution of mitochondrial protein import – lessons from trypanosomes

Biological chemistry, 2019
The evolution of mitochondrial protein import and the systems that mediate it marks the boundary between the endosymbiotic ancestor of mitochondria and a true organelle that is under the control of the nucleus.
A. Schneider
semanticscholar   +1 more source

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Molecules, 2016
Glucose-6-phosphate dehydrogenase (G6PDH) plays a housekeeping role in cell metabolism by generating reducing power (NADPH) and fueling the production of nucleotide precursors (ribose-5-phosphate).
Cecilia Ortiz, Francesca Moraca, Andrea Medeiros, Maurizio Botta, Niall Hamilton, Marcelo A. Comini   +5 more
doaj   +1 more source