Results 31 to 40 of about 14,222 (187)

Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei

Journal of Lipid Research, 2007
Trypanosoma brucei (TB) cultured in rat blood, bovine serum, or lipid-depleted serum generated distinct differences in cholesterol availability. Whereas cell proliferation of the parasite was relatively unaffected by cholesterol availability, the ratios ...
Wenxu Zhou, George A.M. Cross, W. David Nes   +2 more
doaj   +1 more source

Influence of the Draining Lymph Nodes and Organized Lymphoid Tissue Microarchitecture on Susceptibility to Intradermal Trypanosoma brucei Infection

Frontiers in Immunology, 2020
Infection of the mammalian host with African trypanosomes begins when the tsetse fly vector injects the parasites into the skin dermis during blood feeding.
Omar A. Alfituri, Barry M. Bradford, Edith Paxton, Liam J. Morrison, Neil A. Mabbott   +4 more
doaj   +1 more source

The CAF1-NOT complex of trypanosomes [PDF]

Frontiers in Genetics, 2014
In African trypanosomes, there is no control of transcription initiation by RNA polymerase II at the level of individual protein-coding genes. Transcription is polycistronic, and individual mRNAs are excised by trans-splicing and polyadenylation. As a consequence, trypanosomes are uniquely reliant on post-transcriptional mechanisms for control of gene ...
Erben, Esteban, Chakraborty, Chaitali, Clayton, Christine   +2 more
openaire   +3 more sources

The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins

Pathogens, 2017
Lipid rafts are liquid-ordered membrane microdomains that form by preferential association of 3-β-hydroxysterols, sphingolipids and raft-associated proteins often having acyl modifications.
Aabha I. Sharma, Cheryl L. Olson, David M. Engman   +2 more
doaj   +1 more source

Infections With Extracellular Trypanosomes Require Control by Efficient Innate Immune Mechanisms and Can Result in the Destruction of the Mammalian Humoral Immune System

Frontiers in Immunology, 2020
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Stefan Magez, Stefan Magez, Stefan Magez, Joar Esteban Pinto Torres, Emmanuel Obishakin, Emmanuel Obishakin, Magdalena Radwanska, Magdalena Radwanska   +7 more
doaj   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Trypanosomal MICOS Is Assembled on Non‐Respiring Mitochondrial Crista Precursors and Associates With Two Integral Microproteins

Molecular Microbiology, EarlyView.
The mitochondrial membrane‐shaping machinery MICOS is assembled surprisingly early during the life cycle of Trypanosoma brucei, before the mitochondrion acquires its mature architecture or full respiratory capacity. Our study also identifies two previously uncharacterized proteins associated with MICOS, providing new insight into the early organization
Michala Boudová, Teresa Wagner, Tomáš Bílý, Martina Tesařová, Corinna Benz, Hassan Hashimi   +5 more
wiley   +1 more source

Peridomestic infestation by Triatoma pallidipennis and natural infection with Trypanosoma cruzi in Zacatepec, Morelos, Mexico Infestación peridoméstica por Triatoma pallidipennis e infección natural por Trypanosoma cruzi en Zacatepec, Morelos, México

Medical and Veterinary Entomology, EarlyView.
Entomological and community‐related risk factors for Chagas disease were assessed through peridomestic sampling, calculation of entomological indices and surveys of community knowledge, attitudes and practices. Forty‐six triatomines, all identified as Triatoma pallidipennis, were collected, and all specimens showed natural infection with Trypanosoma ...
Reyna Vargas‐Abasolo, José Rafael Delgado López, Liliana Aguilar‐Marcelino, Miguel Galarde‐López, Gemma Rojo, Alex Córdoba‐Aguilar   +5 more
wiley   +1 more source

The exquisite mechanics of a tsetse bite

eLife
Specialized anatomical structures in the mouth and feet of tsetse flies help them feed on blood from a variety of hosts.
Katelyn Fealy, Álvaro Acosta-Serrano
doaj   +1 more source

A multigene family encoding surface glycoproteins in Trypanosoma congolense

Microbial Cell, 2017
Trypanosoma congolense, the causative agent of the most important livestock disease in Africa, expresses specific surface proteins involved in its parasitic lifestyle. Unfortunately, the complete repertoire of such molecules is far from being deciphered.
Magali Thonnus, Amandine Guéri, Loïc Rivière   +2 more
doaj   +1 more source