Results 101 to 110 of about 5,575 (182)

Human African trypanosomiasis presenting at least 29 years after infection--what can this teach us about the pathogenesis and control of this neglected tropical disease? [PDF]

, 2014
No abstract ...
Francesco Checchi, Sarah Lawrence, Angela Vincent, Eligar, Vinay, Capewell, P, Pickrell, William Owen, William Owen Pickrell, Annette MacLeod, Checchi, Francesco, Shumonta Quaderi, Richard Walters, Darshan Sudarshi, Paul Capewell, Michael Brown, Brown, Michael, Alice Walker, MacLeod, Annette, Sudarshi, D, Sudarshi, Darshan, Walters, R, Eligar, V, Walters, Richard, Lawrence, Sarah, Walker, Alice, Caroline Clucas, Vincent, Angela, Vinay Eligar, Clucas, Caroline, Checchi, F, Macleod, A, Vincent, A, Capewell, Paul, Walker, A, Clucas, C, Quaderi, Shumonta, Lawrence, S, Quaderi, S, Brown, M, Pickrell, WO   +38 more
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Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei [PDF]

, 2012
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides.
Burgess, K., Burchmore, Richard J S, Barrett, M.P., Creek, D.J., Vincent, I.M., Woods, Debra, Karl Burgess, Richard J S Burchmore, Woods, Debra J, Creek, Darren, Debra J. Woods (167740), Creek, Darren John, Isabel M Vincent, Vincent, Isabel M, Michael P Barrett, Darren J. Creek (167726), Woods, D.J., Isabel M. Vincent (167717), Woods Debra J., Burgess Karl, Burgess, Karl, Burchmore, Richard, Barrett, Michael P, Vincent, Isabel, Barrett Michael P., Burchmore, R.J.S., Creek Darren J., Richard J. S. Burchmore (167742), Vincent Isabel M., Darren J Creek, Karl Burgess (167732), Debra J Woods, Barrett, Michael, Michael P. Barrett (167748), Burchmore Richard J. S.   +34 more
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Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of human African trypanosomiasis [PDF]

, 2008
Sleeping sickness is caused by a species of trypanosome blood parasite that is transmitted by tsetse flies. To understand better how infection with this parasite leads to disease, we provide here the most detailed description yet of the course of ...
Thuita, J.K., John K. Thuita, Mwangangi, D., C. M. R. Turner, Matovu, E., Masiga, D., Enock Matovu, Kagira John M., John K Thuita, Kagira, J.M., John M. Kagira, David Mwangangi, Turner, C.M.R., Thuita John K., Masiga Daniel, Mwangangi David, Matovu Enock, C M R Turner, Daniel Masiga, Turner C. M. R., John M Kagira   +20 more
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Estimates of the duration of the early and late stage of gambiense sleeping sickness

, 2008
Background: The durations of untreated stage 1 (early stage, haemo-lymphatic) and stage 2 (late stage, meningo-encephalitic) human African trypanosomiasis (sleeping sickness) due to Trypanosoma brucei gambiense are poorly quantified, but key to ...
Filipe, João AN, Haydon Daniel T, Filipe João AN, Chappuis, F., Checchi Francesco, Haydon, D.T., Checchi, F, Checchi, Francesco, Chandramohan, D, Chappuis, F, Chandramohan, Daniel, Filipe, J A N, Filipe, João A N., Haydon, Daniel T, Haydon, D T, Filipe, J.A., Haydon, Daniel T., Checchi, F., Chandramohan, D., Chappuis, François, Chappuis François, Chandramohan Daniel   +21 more
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Chemotherapy of Human African Trypanosomiasis

Interdisciplinary Perspectives on Infectious Diseases, 2009
Human Africa trypanosomiasis is a centuries-old disease which has disrupted sub-Saharan Africa in both physical suffering and economic loss. This article presents an update of classic chemotherapeutic agents, in use for >50 years and the recent ...
Cyrus J. Bacchi
doaj   +1 more source

Early prediction of treatment efficacy in Second-Stage Gambiense Human African Trypanosomiasis

, 2012
Human African trypanosomiasis is fatal without treatment. The long post-treatment follow-up (24 months) required to assess cure complicates patient management and is a major obstacle in the development of new therapies.
Chappuis, F., Bastard, M., Laurence Flevaud, Gerardo Priotto, Etard Jean-François, Flevaud, L., Jean-François Etard, Bastard Mathieu, Etard, Jean-François, Priotto Gerardo, Etard, J-F, Priotto, Gerardo, Priotto, G, Chappuis, F, Flevaud, L, Bastard, Mathieu, François Chappuis, Mathieu Bastard, Bastard, M, Priotto, G., Flevaud Laurence, Chappuis François, Chappuis, François, Flevaud, Laurence   +23 more
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Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from northwestern Uganda following melarsoprol withdrawal [PDF]

, 2009
Human African trypanosomiasis (HAT) manifests as a chronic infection caused by <i>Trypanosoma brucei gambiense</i>, or as a more acute form due to <i>T. b. rhodesiense</i>.
Barbara Nerima, Pascal Mäser, Nerima, B., Barrett, M.P., Nerima, Barbara, de Koning Harry P., Matovu, E., Kazibwe, Anne J., Anne J N Kazibwe, Kazibwe Anne J. N., Enock Matovu, Kazibwe, A.J.N., Mäser, Pascal, De Koning, H.P., Matovu Enock, Harry P de Koning, Barrett Michael P., de Koning, Harry P., Barrett, Michael P., Michael P Barrett, Mäser, P., Mäser Pascal, Matovu, Enock, Nerima Barbara   +23 more
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Eflornithine is Safer Than Melarsoprol for the Treatment of Second-Stage Trypanosoma Brucei Gambiense Human African Trypanosomiasis.

, 2005
Patients with second-stage human African trypanosomiasis treated with eflornithine (n = 251) in 2003 in Kiri, southern Sudan, had an adjusted relative risk of death of 0.2 and experienced significantly fewer cutaneous and neurological adverse effects ...
Chappuis, F, Udayraj, N, Meussen, A, Bovier, P A, Stietenroth, K   +4 more
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Iloprost treatment enhanced IL-4 signalling to reverse trypanosome-induced cognitive deficits and suppressed neuroinflammation in mice

International Journal of Infectious Diseases
Introduction: The development of neurological disorders following trypanosome brain infection has been recognised for over a century. However, an ongoing endeavour persists to comprehensively understand the neurocognitive and neuropathological changes ...
Dr Oluwashola Olaolu, Professor Hajierah Davids, Professor Gill. B Dealtry, Miss Oluwatoyin Morenikeji, Dr Emmanuel T Obishakin, Mrs Binta Iliayasu, Dr Azeez Idris, Dr Chris Duyilemi Ajonijebu   +7 more
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Risk for Human African Trypanosomiasis, Central Africa, 2000–2009

Emerging Infectious Diseases, 2011
Comprehensive georeference records for human African trypanosomiasis in Cameroon, Central African Republic, Chad, Congo, Equatorial Guinea, and Gabon were combined with human population layers to estimate a kernel-smoothed relative risk function.
Pere P. Simarro, Giuliano Cecchi, José R. Franco, Massimo Paone, Eric M. Fèvre, Abdoulaye Diarra, José Antonio Ruiz Postigo, Raffaele C. Mattioli, Jean G. Jannin   +8 more
doaj   +1 more source