Results 11 to 20 of about 14,355 (116)

The Pathogenesis of African Trypanosomiasis

Annual Review of Pathology: Mechanisms of Disease, 2023
African trypanosomes are bloodstream protozoan parasites that infect mammals including humans, where they cause sleeping sickness. Long-lasting infection is required to favor parasite transmission between hosts. Therefore, trypanosomes have developed strategies to continuously escape innate and adaptive responses of the immune system, while also ...
Pays, Etienne, Radwanska, Magdalena, Magez, Stefan   +2 more
openaire   +3 more sources

Management of trypanosomiasis and leishmaniasis [PDF]

British Medical Bulletin, 2012
The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some, there has been significant recent progress. For HAT the only advances in treatment over the past two decades have been the introduction of an eflornithine/nifurtimox ...
Barrett, M.P., Croft, S.L.
openaire   +5 more sources

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, EarlyView.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Effect of Spiroplasma infection on the mating behavior of Glossina fuscipes fuscipes

Insect Science, EarlyView.
Abstract Tsetse flies are insects of significant public health and zoonotic importance as they are the main vectors of African trypanosomes. To date, an effective vaccine is unavailable and efforts to limit the spread of the disease primarily rely on controlling the tsetse populations.
Giulia Fiorenza, Riccardo Piccinno, Daniel J. Bruzzese, Francesca Scolari, Gloria Milanesi, Claudio Casali, Ludvik M. Gomulski, Francesco Lescai, Federico Forneris, Giuliano Gasperi, Kiswend‐sida M. Dera, Chantel de Beer, Adly M.M. Abd‐Alla, Serap Aksoy, Anna R. Malacrida   +14 more
wiley   +1 more source

Stress in dipteran insects mass‐reared for sterile insect technique applications

Insect Science, EarlyView.
The connections between biotic and abiotic stress affecting mass‐reared dipteran insects and the associated stress and immunological responses. Numbers indicate the order in which the topics are discussed in this review. Abstract Stress may be viewed as the disturbance of homeostasis of an organism.
Caroline K. Mirieri, Vera I.D. Ros, Adly M.M. Abd‐Alla, Monique M. van Oers   +3 more
wiley   +1 more source

Cutaneous reactions during treatment with Nifurtimox or Benznidazole among Trypanosoma cruzi seropositive adults without symptomatic cardiomyopathy: A safety sub analysis of a placebo‐controlled randomised trial

Tropical Medicine &International Health, EarlyView.
Abstract Objectives To determine, in a randomised placebo‐controlled trial, if cutaneous adverse reactions during treatment (CARDT) with Benznidazole occur as often as with Nifurtimox, and whether the dose and duration of treatment change that frequency.
Juan Carlos Villar, María Fernanda Saavedra, Pablo Andrés Bermúdez, Eliana Váquiro Herrera, Skarlet Marcell Vásquez, Helena Arango, Antonia Camacho, Mario Javier Olivera   +7 more
wiley   +1 more source

The history of African trypanosomiasis [PDF]

Parasites & Vectors, 2008
The prehistory of African trypanosomiasis indicates that the disease may have been an important selective factor in the evolution of hominids. Ancient history and medieval history reveal that African trypanosomiasis affected the lives of people living in sub-Saharan African at all times.
openaire   +5 more sources

Pandemic Prevention Paradigms: Understanding Global Health Governance

Public Health Challenges, Volume 4, Issue 2, June 2025.
One Health is an emerging area of integrative studies and interventions aimed at preventing zoonotic diseases by addressing human, animal, and environmental interactions. A fundamental aspect of the concept is understanding how these interactions influence health outcomes among humans, animals, and ecosystems. Developed initially to respond to the need
Soheil Sadr, Cinzia Santucciu, Valentina Chisu, Narges Lotfalizadeh, Shakiba Nazemian, Negin Esfandiari, Ashkan Hajjafari, Helia Sepahvand, Abbas Rahdar, Sadanand Pandey, Hassan Borji   +10 more
wiley   +1 more source

Perceived Threat of Zoonotic Infections in Abattoir Workers in the Tamale Metropolis of Ghana: An Assessment of Knowledge, Attitudes and Practices

Public Health Challenges, Volume 4, Issue 2, June 2025.
Most abattoir workers (90.2%) knew that humans can get zoonotic diseases from the animals they handle. However, some respondents believe that witchcraft (20.0%), curses (20.8%) and supernatural powers (18.0%) cause zoonotic diseases. ABSTRACT Background Abattoir workers are more prone to acquiring zoonotic diseases.
Benjamin Nuhu Tingbani, Ezekiel Kofi Vicar, Stephen Apanga, Elijah Bisuman Sambian, Samuel Tamanyian Suuk, Edmond Nakinpaak Biibantib, Williams Walana   +6 more
wiley   +1 more source