Results 151 to 160 of about 476,853 (295)

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Papain- and Trypsin-Derived Spirulina Peptides: Antiproliferative and Antioxidant Profiles. [PDF]

J Food Sci
Hassan SN, Ghafoor DD.
europepmc   +1 more source

Potentiometric determination of trypsin using a polymeric membrane polycation-sensitive electrode based on current-controlled reagent delivery

, 2012
A potentiometric biosensor for the determination of trypsin is described based on current-controlled reagent delivery. A polymeric membrane protamine-sensitive electrode with dinonylnaphthalene sulfonate as cation exchanger is used for in situ generation
Chen, Yan, Ding, Jiawang, Qin, Wei
core  

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Circular Valorization of Yellowfin Tuna (<i>Thunnus albacares</i>) Bone By-Products into Bioactive Hydrolysates Using Endogenous Visceral Proteases Compared with Commercial Trypsin. [PDF]

Molecules
Encalada B, Sisa A, Garcés K, Donoso C, Wilches EP, Martínez-Álvarez O, Ruales J, Mosquera M.   +7 more
europepmc   +1 more source

Trypsin cycling in poultry is associated with metabolic regulation

Frontiers in Physiology, 2023
Vladimir G. Vertiprakhov, Vladimir I. Trukhachev, Natalya V. Ovchinnikova   +2 more
doaj   +1 more source

Re-evaluation of Urinary Trypsin Inhibitor on Pregnancy Course in Patients with Threatened Preterm Delivery : A Single-Center Retrospective Study [PDF]

Background: We evaluated the necessity of urinary trypsin inhibitor for patients with threatened premature labor. Methods: We enrolled 146 women with singleton pregnancies who were treated for threatened premature labor as inpatients.
Tsukihara, Satoru, Nakaso, Takaya, 40322218, Harada, Takashi, 100000380, 571, 3979, 572, Harada, Tasuku, 100000223, 80448191, Taniguchi, Fuminori, 17229, Komatsu, Hiroaki, 17233, 3792, 17230, 17231, 17232, 00437550, Nishimura, Noriko, Kanamori, Yasunobu, 100000412, Sarugami, Masako, 40218649   +24 more
core  

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Investigation of interactions between phytase, protease, and anti-nutritional factors in soybeans. [PDF]

Poult Sci
Drysdale RL, Hufford SW, Engelke GL, Parsons BW.   +3 more
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source