From basic biology to engineered therapies: the keratinocyte stem cell playbook. [PDF]
Uddin A, Rahmani M, Sajini A.
europepmc +1 more source
Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale +6 more
wiley +1 more source
Gene expression and evolution of Bowman-Birk protease inhibitors in wild and domesticated <i>Vigna</i> (Fabaceae) species. [PDF]
Toini E +10 more
europepmc +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Characterization of the acetabular labrum articular surface and its translation into biomimetic graft design. [PDF]
Santschi MXT +7 more
europepmc +1 more source
Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang +16 more
wiley +1 more source
Peptidic product derived from trypsin autolysis modulates insect digestive proteases and supports plant biochemical defense. [PDF]
Paulo DGS +9 more
europepmc +1 more source
Trypsin-Plasmin Inhibitors from Leeches Isolation, Amino Acid Composition, Inhibitory Characteristics [PDF]
Fink, Edwin +3 more
core
Disseminated coccidioidomycosis; combined estrogen-androgen-trypsin therapy.
Charles L. Hoffman, Alexander A. Doerner
openalex

