Results 61 to 70 of about 509,022 (312)

Immobilization of Trypsin in Lignocellulosic Waste Material to Produce Peptides with Bioactive Potential from Whey Protein

Materials, 2016
In this study, trypsin (Enzyme Comission 3.4.21.4) was immobilized in a low cost, lignocellulosic support (corn cob powder—CCP) with the goal of obtaining peptides with bioactive potential from cheese whey.
J. Bassan, Thaís Milena de Souza Bezerra, Guilherme Peixoto, Clariana Zanutto Paulino da Cruz, Julián Paul Martínez Galán, A. Vaz, S. S. Garrido, M. Filice, R. Monti   +8 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Synergistic Effect of Enzyme Preparations and Gentamycin on Biofilms of Bordetella pertussis

Эпидемиология и вакцинопрофилактика, 2023
Relevance. An increase in the incidence of whooping cough, a high proportion of severe forms of the disease, and a decrease in the sensitivity of circulating strains of B.
E. M. Zaitsev, M. V. Britsina, M. N. Ozeretskovskaya, I. G. Bazhanova   +3 more
doaj   +1 more source

IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle

Archives of Virology, 2016
Severe influenza is characterized by a cytokine storm, and the influenza virus–cytokine–trypsin cycle is one of the important mechanisms of viral multiplication and multiple organ failure.
I. L. Indalao, Takako Sawabuchi, E. Takahashi, H. Kido   +3 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Trypsin Cleaves Exclusively C-terminal to Arginine and Lysine Residues*S

Molecular & Cellular Proteomics, 2004
Almost all large-scale projects in mass spectrometry-based proteomics use trypsin to convert protein mixtures into more readily analyzable peptide populations.
J. V. Olsen, Shao-En Ong, M. Mann
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Identification and characterisation of gut proteases in the fig tree skeletoniser moth, Choreutis nemorana Hübner (Lepidoptera: Choreutidae)

Plant Protection Science, 2013
The biochemical properties of proteases from the digestive system of the fig tree skeletonizer moth, Choreutis nemorana, were determined. Gut extracts of C.
Moloud GHOLAMZADEH CHITGAR, Mohammad GHADAMYARI, Mahbobe SHARIFI   +2 more
doaj   +1 more source

Enzymatic Hydrolysis of Soy Protein

Техника и технология пищевых производств, 2023
Soy continues to be one of the top sources of vegetable protein. Structurally modified soy proteins and processed products are used as part of functional foods.
Dmitry V. Sokolov, Bulat A. Bolkhonov, Sesegma D. Zhamsaranova , Svetlana N. Lebedeva, Bayana A. Bazhenova   +4 more
doaj   +1 more source

Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4

Journal of Experimental Medicine, 2012
Pest resistance molecules, α-amylase/trypsin inhibitors from wheat, activate innate immune cells through engagement of TLR4 to elicit inflammatory responses in the intestine.
Y. Junker, S. Zeissig, Seong-Jun Kim, D. Barisani, H. Wieser, D. Leffler, V. Zevallos, T. Libermann, S. Dillon, T. Freitag, C. Kelly, D. Schuppan   +11 more
semanticscholar   +1 more source