Results 101 to 110 of about 341,861 (262)

Prediction of 5-hydroxytryptamine Transporter Inhibitor based on Machine Learning [PDF]

open access: yesarXiv, 2019
In patients with depression, the use of 5-HT reuptake inhibitors can improve the condition. Topological fingerprints, ECFP4, and molecular descriptors were used. Some SERT and small molecules combined prediction models were established by using 5 machine learning methods. We selected the higher accuracy models(RF, SVM, LR) in five-fold cross-validation
arxiv  

Effects of specific inhibitors on the gene expression of a digestive trypsin in Pieris brassicae L. (Lepidoptera: Pieridae)

open access: yesJournal of Plant Protection Research, 2018
Protein digestion in insects relies on several groups of proteases, among which trypsin plays a prominent role. In the current study, larvae of Pieris brassicae L.
Ali Sharifloo   +3 more
doaj   +1 more source

Protein Conformation Generation via Force-Guided SE(3) Diffusion Models [PDF]

open access: yesarXiv
The conformational landscape of proteins is crucial to understanding their functionality in complex biological processes. Traditional physics-based computational methods, such as molecular dynamics (MD) simulations, suffer from rare event sampling and long equilibration time problems, hindering their applications in general protein systems.
arxiv  

Fehérje-kölcsönhatások szerkezeti alapjainak feltárása és a kölcsönhatás szelektív gátlása irányított evolúciós eljárásokkal = Deciphering the structural basis of protein-protein interactions and their selective inhibition via directed evolutionary methods [PDF]

open access: yes, 2012
Fő célom az volt, hogy meghonosítsam az irányított fehérjeevolúció szemléletét, és legsikeresebb technológiáját, a fágbemutatást. Egyrészt azt kutattuk, mi szabja meg a proteáz inhibitorok affinitását és specifitását.
Gráf, László   +2 more
core  

Freeze the BCI until the user is ready: a pilot study of a BCI inhibitor [PDF]

open access: yesarXiv, 2011
In this paper we introduce the concept of Brain-Computer Interface (BCI) inhibitor, which is meant to standby the BCI until the user is ready, in order to improve the overall performance and usability of the system. BCI inhibitor can be defined as a system that monitors user's state and inhibits BCI interaction until specific requirements (e.g.
arxiv  

Arginine substitution by alanine at the P1 position increases the selectivity of CmPI-II, a non-classical Kazal inhibitor

open access: yesBiochemistry and Biophysics Reports, 2021
CmPI-II is a Kazal-type tight-binding inhibitor isolated from the Caribbean snail Cenchritis muricatus. This inhibitor has an unusual specificity in the Kazal family, as it can inhibit subtilisin A (SUBTA), elastases and trypsin. An alanine in CmPI-II P1
Laritza Rojas   +5 more
doaj  

A pure trypsin inhibitor from soya beans [PDF]

open access: green, 1963
Yehudith Birk   +2 more
openalex   +1 more source

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